Wildlife damage to forests has become an increasingly serious problem in recent years, and its impact is exacerbated by ongoing climate change. Rising temperatures, prolonged droughts, uneven precipitation distribution, and other factors affect forest ecosystems, which, in turn, affect cloven-hoofed animal populations, their food preferences, and ultimately, the extent of damage they cause. Based on 133 references, this review article focuses on the relationships between wildlife damage and climate change and presents possible strategies to address this issue in the Czech Republic. Wildlife damage includes not just browsing and fraying in natural and artificial regeneration but also damage to trees from bark stripping and the lesser-known rooting of seedlings. Concerning tree species, browsing is most damaging to silver fir (Abies alba Mill.) and sycamore maple (Acer pseudoplatanus L.). The enticement to wildlife increases as the proportion of the tree species in the stand decreases. Browse damage is more severe at the edge of the stand. Bark stripping and secondary rot cause the most damage to the production quality of Norway spruce (Picea abies [L.] Karst.). Total wildlife damage increases with elevation. Combined with the progress of climate change, game-induced damage significantly restricts close-to-nature forest management practices and limits the use of adaptive measures in response to climate change. In addition, mixed forests with species that attract wildlife and the rapid increase in the number of clearings following bark beetle salvage logging significantly increase game pressure. This is primarily the result of the overpopulation of native and introduced game species and the considerable inconsistency between forest and hunting management practices, with the latter not respecting the principle of ecologically tolerable game damage.