2022
DOI: 10.3389/fonc.2022.804983
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From Tumor Cells to Endothelium and Gut Microbiome: A Complex Interaction Favoring the Metastasis Cascade

Abstract: Metastasis is a complicated process through which tumor cells disseminate to distant organs and adapt to novel tumor microenvironments. This multi-step cascade relies on the accumulation of genetic and epigenetic alterations within the tumor cells as well as the surrounding non-tumor stromal cells. Endothelial cells constitute a major player in promoting metastasis formation either by inducing the growth of tumor cells or by directing them towards dissemination in the blood or lymph. In fact, the direct and in… Show more

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Cited by 3 publications
(1 citation statement)
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References 190 publications
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“…This directly facilitated tumor colonization in the lungs of murine breast cancer models. 74 Similarly, endomucin, which is involved in the tube formation of ECs, is downregulated in several cancers. Deficiency of endomucin on ECs results in increased vascular permeability and recruited tumorsupporting N2-type neutrophils at the premetastatic niche in a murine lung carcinoma model.…”
Section: Metastasismentioning
confidence: 99%
“…This directly facilitated tumor colonization in the lungs of murine breast cancer models. 74 Similarly, endomucin, which is involved in the tube formation of ECs, is downregulated in several cancers. Deficiency of endomucin on ECs results in increased vascular permeability and recruited tumorsupporting N2-type neutrophils at the premetastatic niche in a murine lung carcinoma model.…”
Section: Metastasismentioning
confidence: 99%