We derive bounds on the extremal singular values and the condition number of N × K, with N K, Vandermonde matrices with nodes in the unit disk. The mathematical techniques we develop to prove our main results are inspired by a link-first established by Selberg [1] and later extended by Moitra [2]-between the extremal singular values of Vandermonde matrices with nodes on the unit circle and large sieve inequalities. Our main conceptual contribution lies in establishing a connection between the extremal singular values of Vandermonde matrices with nodes in the unit disk and a novel large sieve inequality involving polynomials in z ∈ C with |z| 1. Compared to Bazán's upper bound on the condition number [3], which, to the best of our knowledge, constitutes the only analytical result-available in the literature-on the condition number of Vandermonde matrices with nodes in the unit disk, our bound not only takes a much simpler form, but is also sharper for certain node configurations. Moreover, the bound we obtain can be evaluated consistently in a numerically stable fashion, whereas the evaluation of Bazán's bound requires the solution of a linear system of equations which has the same condition number as the Vandermonde matrix under consideration and can therefore lead to numerical instability in practice. As a byproduct, our result-when particularized to the case of nodes on the unit circle-slightly improves upon the Selberg-Moitra bound.