From Wasting to Obesity, Changes in Nutritional Concerns in HIV/AIDS

Mankal, Pavan; Kotler, Donald P.

doi:10.1016/j.ecl.2014.05.004

Cited by 35 publications

(30 citation statements)

References 75 publications

Supporting

Mentioning

Contrasting

Unclassified

Order By: Relevance

“…Additionally, weight ( p = 0.0037) and body mass index (BMI, p = 0.0093) positively correlated with peripheral CD4 T cell count in HIV-infected subjects (Figure 1C, 1D). These clinical characteristics are consistent with the known effects of HIV infection (Mankal and Kotler, 2014; Palermo et al, 2011; Phillips et al, 2010). …”

Section: Resultssupporting

confidence: 85%

Altered Virome and Bacterial Microbiome in Human Immunodeficiency Virus-Associated Acquired Immunodeficiency Syndrome

Monaco

Gootenberg

Zhao

et al. 2016

Cell Host & Microbe

356

342

View full text Add to dashboard Cite

SUMMARY Human immunodeficiency virus (HIV) infection is associated with increased intestinal translocation of microbial products and enteropathy as well as alterations in gut bacterial communities. However, whether the enteric virome contributes to this infection and resulting immunodeficiency remains unknown. We characterized the enteric virome and bacterial microbiome in a cohort of Ugandan patients, including HIV-uninfected or HIV-infected subjects and those either treated with anti-retroviral therapy (ART) or untreated. Low peripheral CD4 T cell counts were associated with an expansion of enteric adenovirus sequences and this increase was independent of ART treatment. Additionally, the enteric bacterial microbiome of patients with lower CD4 T counts exhibited reduced phylogenetic diversity and richness with specific bacteria showing differential abundance, including increases in Enterobacteriaceae, which have been associated with inflammation. Thus, immunodeficiency in progressive HIV infection is associated with alterations in the enteric virome and bacterial microbiome, which may contribute to AIDS-associated enteropathy and disease progression.

show abstract

Section: Resultssupporting

confidence: 85%

Altered Virome and Bacterial Microbiome in Human Immunodeficiency Virus-Associated Acquired Immunodeficiency Syndrome

Monaco

Gootenberg

Zhao

et al. 2016

Cell Host & Microbe

356

342

View full text Add to dashboard Cite

show abstract

“…The importance of good nutrition in maintaining optimal health and delaying disease progression among HIV-infected patients has been documented in the literature (1,2) . At the beginning of the HIV epidemic, wasting was one of the main nutritionally related concerns; however, rates of obesity are now more common than the occurrence of wasting (3)(4)(5) , particularly in patients on antiretroviral treatment (ART) (6) .…”

mentioning

confidence: 99%

Effect of BMI and fat mass on HIV disease progression in HIV-infected, antiretroviral treatment-naïve adults in Botswana

et al. 2016

View full text Add to dashboard Cite

An obesity paradox has been proposed in many conditions including HIV. Studies conducted to investigate obesity and its effect on HIV disease progression have been inconclusive and are lacking for African settings. This study investigated the relationship between overweight/obesity (BMI ≥25 kg/m2) and HIV disease progression in HIV+ asymptomatic adults not on antiretroviral treatment (ART) in Botswana over 18 months. A cohort study in asymptomatic, ART-naïve, HIV+ adults included 217 participants, 139 with BMI of 18.0–24.9 kg/m2 and seventy-eight participants with BMI ≥25 kg/m2. The primary outcome was time to event (≥25 % decrease in cluster of differentiation 4 (CD4) cell count) during 18 months of follow-up; secondary outcomes were time to event of CD4 cell count <250 cells/μl and AIDS-defining conditions. Proportional survival hazard models were used to compare hazard ratios (HR) on time to events of HIV disease progression over 18 months. Higher baseline BMI was associated with significantly lower risk of an AIDS-defining condition during the follow-up (HR 0.218; 95% CI 0.068, 0.701; P = 0.011). Higher fat mass at baseline was also significantly associated with decreased risk of AIDS-defining conditions during the follow-up (HR 0.855; 95% CI 0.741, 0.987; P = 0.033) and the combined outcome of having CD4 cell count ≤250/μl and AIDS-defining conditions, whichever occurred earlier (HR 0.918; 95% CI 0.847, 0.994; P= 0.036). All models were adjusted for covariates. Higher BMI and fat mass among the HIV-infected, ART-naïve participants were associated with slower disease progression. Mechanistic research is needed to evaluate the association between BMI, fat mass and HIV disease progression.

show abstract

“…Rats infected with the human immunodeficiency virus (HIV) lose weight (predominantly due to muscle wasting, with minor changes in fat proportion) (5), which could in part decrease irisin secretion. In a subcohort of morbidly obese subjects with metabolic disorders, circulating irisin levels were significantly associated with FNDC5 gene expression in subcutaneous and visceral adipose tissues instead of muscle mass (6,7).…”

Section: Introductionmentioning

confidence: 99%

New insights into the effects of irisin levels in HIV-infected subjects: correlation with adiposity, fat-free mass, and strength parameters

Trombeta

Prestes

Nascimento

et al. 2017

Arch. Endocrinol. Metab.

View full text Add to dashboard Cite

Objective: Patients infected with the human immunodeficiency virus (HIV) have an increased risk of metabolic disorders and alterations on irisin levels. Therefore, the purpose of the current investigation was to quantify the circulating irisin concentration in HIV-infected subjects under highly active antiretroviral therapy and to determine possible correlations between irisin levels with fat mass, fat-free mass, body mass index (BMI), and muscle strength. Subjects and methods: Cross-sectional study of 10 men (36.7 ± 11.3 years) and 10 women (42.5 ± 10.3 years) infected with HIV, recruited from the Specialized Service Center in the State Center of Reference for High and Medium Complexity. Blood samples were collected to determine plasma irisin levels, glucose, HDL, total cholesterol, triglycerides, and LDL. Body composition (fat mass, fat-free mass) and anthropometrics (body mass index; BMI) were measured by bioelectrical impedance. Muscle strength was assessed using a mechanic hand dynamometer and one maximum repetition tests. Results: Irisin levels correlated positively with fat mass (r = 0.67; p = 0.001) and BMI (r = 0.48; p = 0.036). In contrast, there was an inverse correlation between irisin levels and fat-free mass (r = -0.41; p = 0.008) and five strength parameters: right hand grip (r = -0.46; p = 0.044); left hand grip (r = -0.50; p = 0.027), relative hand grip (r = -0.79; p = 0.001), bench press (r = -0.58; p = 0.009), leg press (r = -0.40; p = 0.085), and biceps curl (r = -0.059; p = 0.009). Conclusion: Irisin levels correlated positively with body fat and negatively with fat-free mass and strength parameters in HIV-infected patients. Female patients infected with HIV receiving highly active antiretroviral therapy have higher levels of irisin compared with men in a similar circumstance. Arch Endocrinol Metab. 2017;61(3):382-90.

show abstract

From Wasting to Obesity, Changes in Nutritional Concerns in HIV/AIDS

Cited by 35 publications

References 75 publications

Altered Virome and Bacterial Microbiome in Human Immunodeficiency Virus-Associated Acquired Immunodeficiency Syndrome

Altered Virome and Bacterial Microbiome in Human Immunodeficiency Virus-Associated Acquired Immunodeficiency Syndrome

Effect of BMI and fat mass on HIV disease progression in HIV-infected, antiretroviral treatment-naïve adults in Botswana

New insights into the effects of irisin levels in HIV-infected subjects: correlation with adiposity, fat-free mass, and strength parameters

Contact Info

Product

Resources

About