From weight loss to weight gain: appetite changes in major depressive disorder as a mirror into brain-environment interactions

Privitera, Gregory J.; Misenheimer, Melissa L.; Doraiswamy, P. Murali

doi:10.3389/fpsyg.2013.00873

Cited by 30 publications

(26 citation statements)

References 13 publications

(10 reference statements)

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“…The results corroborate recent theories suggesting that depression and obesity are related to emotional eating (Nestler, 2012;Privitera et al, 2013) and highlight the need to identify depression as a possible risk factor for increased intake and choices for energy-dense foods in response to daily, short-term fluctuations in sad emotion, specifically among those individuals who are obese.…”

Section: Discussionsupporting

confidence: 86%

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Differential food intake and food choice by depression and body mass index levels following a mood manipulation in a buffet-style setting

et al. 2016

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While eating in response to emotional cues is associated with intake of unhealthy foods, less is known about the extent to which obesity and depression may differentially influence food intake in a buffet-style setting where low- and high-calorie foods are available to choose from. Using a counterbalanced design, 154 participants were grouped by depression and obesity categories, then asked to read a series of vignettes that were sad (on 1 day) and neutral (on a different day), followed by a buffet to eat until full. Food intake (in grams and calories) and food choice (number of high- or low-calorie food options) were recorded. Results showed that participants who were obese and depressed had significantly greater energy intake following the sad versus happy vignette, largely due to increased intake of high-calorie foods. The results corroborate recent theories on emotional eating and extend the ecological validity of such effects in a buffet-style setting.

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Section: Discussionsupporting

confidence: 86%

“…Diagnostic criteria for depression are further linked to increases in the intake of comfort foods (Privitera et al, 2013(Privitera et al, , 2015Smith and Ditschun, 2009), although the extent to which emotional eating is specifically related to depression is less understood.…”

Section: Introductionmentioning

confidence: 99%

Differential food intake and food choice by depression and body mass index levels following a mood manipulation in a buffet-style setting

et al. 2016

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“…Increased and decreased appetite are core features of depression diagnosis which is an explanatory factor of weight change in depressed persons (Privitera et al, 2013). In addition, previous research reported an association between food insufficiency and dysthymia, however this was not found for MDD (Alaimo et al, 2002).…”

Section: Discussionmentioning

confidence: 96%

Depressive and anxiety disorders: Associated with losing or gaining weight over 2 years?

Wit

Straten

Lamers

et al. 2015

Psychiatry Research

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a b s t r a c tThis longitudinal study examines to what extent different depressive and anxiety disorders and clinical characteristics are associated with subsequent weight change, while controlling for baseline weight, sociodemographics, health status, psychotropic medication use and (un)healthy lifestyle factors. Data are from a sample of 2447 respondents aged 18-65 years of the Netherlands Study of Depression and Anxiety (NESDA). Baseline depressive disorders and anxiety disorders were determined with the Composite International Diagnostic Interview (CIDI). Weight at baseline and after 2 years was measured and analyzed as continuous change score (mean change in weight 1 kg) and in categories of significant weight loss ( o1 S.D. weight change equaling o 4 kg), weight maintenance and weight gain ( 41 S.D., 46 kg). After full adjustment for covariates baseline comorbid anxiety and depressive disorder and baseline Major Depressive Disorder (MDD) were associated with significant 2-year weight gain. Both current and remitted MDD at baseline and a baseline dysthymia, but none of the anxiety disorders, were associated with significant weight loss. This longitudinal study confirms a U-curved link between depression and weight change over 2 years. Furthermore, a dose-response effect of depression severity on 2-year weight gain was found.

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“…Our hypothesis regarding the strength of association and predictive strength of psychological factors over biological factors being similar between the two IBD subtypes was refuted, though it can be argued that weight loss [47] and abdominal tenderness and potentially visceral hypersensitivity (in the CD population) may have psychosomatic underpinnings [26] and not be completely related to disease activity. Given these results, one may hypothesize that the non-transmural inflammation involved in UC does not lead to a strong enough afferent signal in comparison to psychological comorbidity affecting pain perception, given data noting enteric nervous system abnormalities that are more pronounced in CD than UC [48].…”

Section: Discussionmentioning

confidence: 99%

Predictors of Abdominal Pain in Depressed Pediatric Inflammatory Bowel Disease Patients

Srinath

Goyal

Zimmerman

et al. 2014

Inflammatory Bowel Diseases

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Background Pediatric patients with inflammatory bowel disease (IBD) have high rates of abdominal pain. The study aims were to (1) Evaluate biological and psychological correlates of abdominal pain in depressed youth with IBD, (2) Determine predictors of abdominal pain in Crohn’s disease (CD) and ulcerative colitis (UC). Methods 765 patients ages 9–17 with IBD seen over 3 years at two sites were screened for depression. Depressed youth completed comprehensive assessments for abdominal pain, psychological (depression and anxiety), and biological (IBD-related, through disease activity indices and laboratory values) realms. Results 217 patients with IBD (161 CD, 56 UC) were depressed. 163 (120 CD, 43 UC) patients had complete API scores. In CD, abdominal pain was associated with depression (r=0.33; p<0.001), diarrhea (r=0.34; p=0.001), ESR (r=0.22; p=0.02), low albumin (r=0.24; p=.01), weight loss (r=0.33; p=0.001), and abdominal tenderness (r=0.38, p=0.002). A multivariate model with these significant correlates represented 32% of the variance in pain. Only depression (p=0.03), weight loss (p=0.04), and abdominal tenderness (p=0.01) predicted pain for CD patients. In UC, pain was associated with depression (r=0.46; p=0.002) and nocturnal stools (r=.32; p=.046). In the multivariate model with these significant correlates 23% of the variance was explained, and only depression (p=0.02) predicted pain. Conclusions The psychological state of pediatric patients with IBD may increase the sensitivity to abdominal pain. Thus, screening for and treating comorbid depression may prevent excessive medical testing and unnecessary escalation of IBD medications.

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From weight loss to weight gain: appetite changes in major depressive disorder as a mirror into brain-environment interactions

Cited by 30 publications

References 13 publications

Differential food intake and food choice by depression and body mass index levels following a mood manipulation in a buffet-style setting

Differential food intake and food choice by depression and body mass index levels following a mood manipulation in a buffet-style setting

Depressive and anxiety disorders: Associated with losing or gaining weight over 2 years?

Predictors of Abdominal Pain in Depressed Pediatric Inflammatory Bowel Disease Patients

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