From Zero to Many: Control of Centriole Number in Development and Disease

Cunha-Ferreira, Inês; Bento, Inês; Bettencourt-Dias, Mónica

doi:10.1111/j.1600-0854.2009.00905.x

Cited by 43 publications

(38 citation statements)

References 215 publications

(279 reference statements)

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“…1C,D). Centrioles of cultured cells also lack the C-tubule (Cunha-Ferreira et al, 2009). We never found structural differences between mother and daughter centrioles in the somatic cells examined.…”

Section: Results and Discussion Somatic And Germline Centrioles -Diffmentioning

confidence: 99%

The Drosophila centriole: conversion of doublets to triplets within the stem cell niche

Gottardo

Callaini

Riparbelli

2015

Journal of Cell Science

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We report here that two distinct centriole lineages exist in Drosophila: somatic centrioles usually composed by microtubule doublets and germ line centrioles characterized by triplets. Remarkably, the transition from doublets to triplets in the testis occurs within the stem cell niche with the formation of the C-tubule. We demonstrated that the old mother centriole that stays in the apical cytoplasm of the male germline stem cells (GSCs) is invariably composed by triplets, whereas its daughter is always built by mixed doublets and triplets. This difference represents the first documentation of a structural asymmetry between mother and daughter centrioles in Drosophila GSCs and may reflect a correlation between the architecture of parent centrioles and their ability to recruit centrosomal proteins. We also found that the old mother centriole is linked to the cell membrane by distinct projections that may play an important role in keeping its apical position during centrosome separation.

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Section: Results and Discussion Somatic And Germline Centrioles -Diffmentioning

confidence: 99%

The Drosophila centriole: conversion of doublets to triplets within the stem cell niche

Gottardo

Callaini

Riparbelli

2015

Journal of Cell Science

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“…Despite this difficulty, centrosomal proteins often contribute to centrosome homeostasis. 12,25 The characterization of SF-1 as a centrosomal protein provides a possible mechanism for this nongenomic SF-1 function. Our results reveal a novel function of SF-1 in maintaining centrosome homeostasis possibly through its centrosomal, but not nuclear, localization.…”

Section: Discussionmentioning

confidence: 99%

Steroidogenic Factor 1 (NR5A1) resides in centrosomes and maintains genomic stability by controlling centrosome homeostasis

et al. 2011

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“…The core centriole assembly pathway was initially described in Caenorhabditis elegans and is conserved in various animal species (Nigg, 2007;Strnad and Gonczy, 2008;Cunha-Ferreira et al, 2009a;Nigg and Raff, 2009). SPICE-related sequences seem to be present only in vertebrates.…”

Section: Spice Depletion Impairs Spindle Architecture Independent Of mentioning

confidence: 99%

SPICE – a previously uncharacterized protein required for centriole duplication and mitotic chromosome congression

Archinti

Lacasa

Teixidó-Travesa

et al. 2010

Journal of Cell Science

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SummaryProper assembly and function of a bipolar mitotic spindle is crucial for faithful bidirectional chromosome segregation during cell division. In animal cells, the two poles of the mitotic spindle are organized by centrosomes, microtubule-organizing structures composed of a pair of centrioles surrounded by the so-called pericentriolar material. Proteomic studies have revealed a large number of centrosome proteins, but many remain uncharacterized. Here, we characterize SPICE, a protein that localizes to spindle microtubules in mitosis and to centrioles throughout the cell cycle. RNAi-mediated depletion of SPICE in human cells impairs centriole duplication and causes severe mitotic defects. SPICE depletion compromises spindle architecture, spindle pole integrity and chromosome congression, even in cells in which centriole duplication has occurred. Our data suggest that SPICE is an important dual-function regulator required for centriole duplication and for proper bipolar spindle formation and chromosome congression in mitosis.

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From Zero to Many: Control of Centriole Number in Development and Disease

Cited by 43 publications

References 215 publications

The Drosophila centriole: conversion of doublets to triplets within the stem cell niche

The Drosophila centriole: conversion of doublets to triplets within the stem cell niche

Steroidogenic Factor 1 (NR5A1) resides in centrosomes and maintains genomic stability by controlling centrosome homeostasis

SPICE – a previously uncharacterized protein required for centriole duplication and mitotic chromosome congression

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