Front Cover: Anion‐π Interaction for Molecular Recognition of Anions: Focus on Cooperativity with Hydrogen Bonding (Eur. J. Org. Chem. 9/2023)

Abstract

The Front Cover shows the combination of anion‐π interaction and hydrogen bonding, which provides some synergistic effects called “cooperativity”. On this cover picture, this recent concept of supramolecular chemistry is illustrated by two characters that help each other to select and recognize anions of different size and shapes. The cartoon was created by Mrs. Naseem Farzand. More information can be found in the Review by R. Plais et al.

Tetrafluoroterephthalonitrile as an anion‐π donor: theoretical evaluation and application to anion recognition

“…[9] The exploration of binding properties of receptors combining both H-bond donor and anion-π donor fragments is an emerging trend depending on the nature of the two fragments involved and the topology of the receptor. [10] As an example, within the same family of receptors combining urea and tetrazine derivatives, cooperative or anti-cooperative effects on chloride binding events have recently been observed. [10][11][12][13] Furthermore, the symmetric architecture and 1,4-bis-substitution pattern of stetrazine derivatives tend to form receptor-anion complexes with a preferential η 6 coordination mode.…”

“…[10] As an example, within the same family of receptors combining urea and tetrazine derivatives, cooperative or anti-cooperative effects on chloride binding events have recently been observed. [10][11][12][13] Furthermore, the symmetric architecture and 1,4-bis-substitution pattern of stetrazine derivatives tend to form receptor-anion complexes with a preferential η 6 coordination mode. [12] Therefore, moving from tetrazine derivatives to new anion-π-acidic arenes [10] will allow gaining insights into the relationship between fragments and rationalizing binding events for a better understanding of the associated recognition phenomena and fine structureproperties relationships.…”