Front Cover: Effect of gem‐Difluorination on the Key Physicochemical Properties Relevant to Medicinal Chemistry: The Case of Functionalized Cycloalkanes (Chem. Eur. J. 19/2022)

Abstract

The CF2 dragon reborn! The difluoromethylene dragon has evolved from difluorocyclopropanations (presented in a series of previous covers, see Adv. Synth. Catal., DOI: 201801304 and Eur. J. Org. Chem. 201900911) to the full strength of all other gem‐difluorocycloalkanes. In the Research Article by O. O. Grygorenko and co‐authors (DOI: 10.1002/chem.202200331), the key in vitro properties of functionalized gem‐difluorinated cycloalkanes (pKa, log P, aqueous solubility, and intrinsic clearance) are discussed thoroughly.