Front Cover: Identification of Highly Expressed <i>Plasmodium Vivax</i> Proteins from Clinical Isolates Using Proteomics

Venkatesh, Apoorva; Lahiri, Anwesha; Reddy, Panga Jaipal; Shastri, Jayanthi; Bankar, Sheetal; Patankar, Swati; Srivastava, Sanjeeva

doi:10.1002/prca.201870030

Cited by 3 publications

(2 citation statements)

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“…The tryptophan-rich protein PvTRAg38 has two erythrocyte-binding regions, of which one interacts with erythrocyte receptor band 3 [64, 65] and the second binding domain interacts with basigin [66] (Table 2), which is the receptor for RH5 [67, 68] and rhoptry-associated protein 2 [69] in P. falciparum. Interestingly, some tryptophan-rich proteins are highly expressed in clinical isolates, suggesting that these proteins are important in P. vivax infection [70].…”

Section: Other Potential Ligands Of P Vivaxmentioning

confidence: 99%

Plasmodium vivax Infections of Duffy-Negative Erythrocytes: Historically Undetected or a Recent Adaptation?

Gunalan

Niangaly²,

Thera³

et al. 2018

Trends in Parasitology

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Plasmodium vivax is the main cause of malarial disease in Asia and South America. Plasmodium vivax infection was thought to be absent in African populations who are Duffy blood group antigen negative (Duffy-negative). However, many cases of P. vivax infection have recently been observed in Duffy-negative Africans. This raises the question: were P. vivax infections in Duffy-negative populations previously missed or has P. vivax adapted to infect Duffy-negative populations? This review focuses on recent P. vivax findings in Africa and reports views on the parasite ligands that may play a role in Duffy-negative P. vivax infections. In addition, clues gained from studying P. vivax infection of reticulocytes are presented, which may provide possible avenues for establishing P. vivax culture in vitro.

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Section: Other Potential Ligands Of P Vivaxmentioning

confidence: 99%

Plasmodium vivax Infections of Duffy-Negative Erythrocytes: Historically Undetected or a Recent Adaptation?

Gunalan

Niangaly²,

Thera³

et al. 2018

Trends in Parasitology

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“…This protein has been shown to bind to erythrocyte receptor, which is chymotrypsinsensitive (47), and it was later identified to be band 3 protein in the erythrocytes (52). Furthermore, of the six tryptophan-rich genes expressed higher in Saimiri than Aotus, five were shown to bind erythrocytes (46)(47)(48) and PVX_090265 was shown to be highly expressed in clinical isolates (53). The three tryptophan-rich antigens up-regulated in Aotus monkeys did not bind erythrocytes (46,47).…”

Section: Differential Expression Of Different Family Members In P Vivaxmentioning

confidence: 99%

Transcriptome profiling ofPlasmodium vivaxinSaimirimonkeys identifies potential ligands for invasion

Gunalan

Sá

Barros

et al. 2019

Proc. Natl. Acad. Sci. U.S.A.

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Unlike the case in Asia and Latin America,Plasmodium vivaxinfections are rare in sub-Saharan Africa due to the absence of the Duffy blood group antigen (Duffy antigen), the only known erythrocyte receptor for theP. vivaxmerozoite invasion ligand, Duffy binding protein 1 (DBP1). However,P. vivaxinfections have been documented in Duffy-negative individuals throughout Africa, suggesting thatP. vivaxmay use ligands other than DBP1 to invade Duffy-negative erythrocytes through other receptors. To identify potentialP. vivaxligands, we compared parasite gene expression inSaimiriandAotusmonkey erythrocytes infected withP. vivaxSalvador I (Sal I). DBP1 bindsAotusbut does not bind toSaimirierythrocytes; thus,P. vivaxSal I must invadeSaimirierythrocytes independent of DBP1. Comparing RNA sequencing (RNAseq) data for late-stage infections inSaimiriandAotuserythrocytes when invasion ligands are expressed, we identified genes that belong to tryptophan-rich antigen and merozoite surface protein 3 (MSP3) families that were more abundantly expressed inSaimiriinfections compared withAotusinfections. These genes may encode potential ligands responsible forP. vivaxinfections of Duffy-negative Africans.

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Review of Liquid Chromatography-Mass Spectrometry-Based Proteomic Analyses of Body Fluids to Diagnose Infectious Diseases

Hayoung

Kim

2022

IJMS

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Rapid and precise diagnostic methods are required to control emerging infectious diseases effectively. Human body fluids are attractive clinical samples for discovering diagnostic targets because they reflect the clinical statuses of patients and most of them can be obtained with minimally invasive sampling processes. Body fluids are good reservoirs for infectious parasites, bacteria, and viruses. Therefore, recent clinical proteomics methods have focused on body fluids when aiming to discover human- or pathogen-originated diagnostic markers. Cutting-edge liquid chromatography–mass spectrometry (LC-MS)-based proteomics has been applied in this regard; it is considered one of the most sensitive and specific proteomics approaches. Here, the clinical characteristics of each body fluid, recent tandem mass spectroscopy (MS/MS) data-acquisition methods, and applications of body fluids for proteomics regarding infectious diseases (including the coronavirus disease of 2019 [COVID-19]), are summarized and discussed.

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Front Cover: Identification of Highly Expressed Plasmodium Vivax Proteins from Clinical Isolates Using Proteomics

Cited by 3 publications

References 0 publications

Plasmodium vivax Infections of Duffy-Negative Erythrocytes: Historically Undetected or a Recent Adaptation?

Plasmodium vivax Infections of Duffy-Negative Erythrocytes: Historically Undetected or a Recent Adaptation?

Transcriptome profiling ofPlasmodium vivaxinSaimirimonkeys identifies potential ligands for invasion

Review of Liquid Chromatography-Mass Spectrometry-Based Proteomic Analyses of Body Fluids to Diagnose Infectious Diseases

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