Front Cover: NAD(H)‐PEG Swing Arms Improve Both the Activities and Stabilities of Modularly‐Assembled Transhydrogenases Designed with Predictable Selectivities (ChemBioChem 3/2022)
Abstract:The modular assembly of synthetic transhydrogenase catalysts is demonstrated using a PEG‐NAD(H) modified formate dehydrogenase (FDH)‐SpyCatcher fusion protein. The front cover highlights how any oxidoreductase enzyme can be outfitted with a simple SpyTag peptide and conjugated to FDH‐SpyCatcher to create new cofactor‐independent biocatalysts driven by formate oxidation. The stabilities and catalytic properties of the resulting transhydrogenases are improved without detriment to the selectivities of the native … Show more
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