Front Cover Picture: From Peripheral Stereogenic Center to Axial Chirality: Synthesis of 3‐Arylthiophene Atropisomers (Adv. Synth. Catal. 4/2023)

Abstract

The front cover picture illustrates the palladium‐catalyzed the chirality transfer from peripheral stereogenic carbon center to axial chirality starting from 8H‐indenothiophen‐8‐ols. The process is different from traditional point‐to‐axial chirality transfer aromatization reaction of a non‐aromatic intermediate, in which the new created chiral axis is usually directly attach to a stereogenic centers. This reaction provides an easy way to access highly functionalized 3‐arylthiophene atropisomers in high enantioselectivity. Details can be found in the Update by Junwei Xi, Zhenhua Gu and co‐workers (L. Li, J. Xi, B. Hong, Z. Gu, Adv. Synth. Catal. 2023, 365, 594–599; DOI: 10.1002/adsc.202200957).

Metal and catalyst-free strategy to access 1,3-thio-heteroaryl BCP derivatives

“…The reaction was performed with different bases to ease the proton abstraction step, among which 2 equiv. DBU was found to be efficient for this transformation, delivering product 4a in 58% yield (Table 1, entries [6][7][8][9][10][11]. Next, screening different light sources (390 nm, 440 nm, or 467 nm) did not improve the reaction yield.…”

“…While our manuscript was under preparation, the Jirong Wu group published similar results. 11 Our methodology is extended to synthesize 2H-indazole derived heterocycles that are widely employed in medicinal chemistry and materials research.…”

C–H activation-initiated spiroannulation reactions and their applications in the synthesis of spirocyclic compounds

“…This journal is © The Royal Society of Chemistry 2024 cheap and commercially available cobalt catalyst and excellent reaction regioselectivity (Scheme 24). 20 Compared with oximes, O-pivaloyl oximes, amidines, N-phenoxy acetamides and amides, amines are more readily accessible and can often be obtained from natural sources. Therefore, CHA reactions using a free amino group as a DG are highly desirable.…”

Radical reactions enabled by polyfluoroaryl fragments: photocatalysis and beyond

“…108 In addition, activation of the C-H bond can also proceed in the absence of HAT-cocatalyst through an oxidation/deprotonation sequence. 109 In 2021, Wang and co-workers described a method for the photocatalytic alkylation of polyfluoroarenes via MOMprotected alcohols as an alkyl radical source (Scheme 31). 110 This deoxygenative process proceeds in the presence of an iridium photocatalyst and thiol S1 as a HAT-mediator (see Scheme 20).…”