Front Cover Picture: Haloalkenyl Imidoyl Halides as Multifacial Substrates in the Stereoselective Synthesis of N‐Alkenyl Compounds (Adv. Synth. Catal. 13/2021)

Abstract

The front cover picture illustrates the reaction of N‐fluoroalkylated‐1,2,3‐triazoles with aluminum trihalide, proceeding via a vinyl cation (illustrated as the structure in brackets in the middle) to afford structurally diverse N‐haloalkenyl imidoyl halides. These products are formed in a stereoselective fashion on both double bonds and have been utilized in the synthesis of various N‐alkenyl compounds, such as enamides, enamidines, enimines, N‐alkenyl tetrazoles, and other. In this work, Beier and co‐workers show a new, mild and efficient 1,2,3‐triazole denitrogenative ring‐opening process mediated by easily available Lewis acids. Details can be found in the Full Paper by Beier and co‐workers (A. Markos, L. Janecký, T. Chvojka, T. Martinek, H. Martinez‐Seara, B. Klepetářová, P. Beier, Adv. Synth. Catal. 2021, 363, 3258–3266; DOI: 10.1002/adsc.202100009).