Frontal alpha asymmetry as a pathway to behavioural withdrawal in depression: Research findings and issues

Jesulola, Emmanuel; Sharpley, Christopher F.; Bitsika, Vicki; Agnew, Linda L.; Wilson, Peter H.

doi:10.1016/j.bbr.2015.05.058

Cited by 88 publications

(67 citation statements)

References 178 publications

(250 reference statements)

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“…Note excessive amplitude of P1 wave in comparison to the reference. A similar pattern is seen in a sub-group of patients with depression [9]. Anodal tDCS of the left frontal cortex was suggested as effective treatment of this condition [12].…”

Section: Resultssupporting

confidence: 65%

“…According to this hypothesis, some patients with depression show excessive frontal alpha on the left side and consequently reveal a frontal alpha asymmetry. In such cases, a specific alpha asymmetry neurofeedback protocol was suggested for the treatment symptoms of depression [9]. For testing this hypothesis, EEG spectra of the patient were computed for all conditions and compared with the reference database.…”

Section: Case Studymentioning

confidence: 99%

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Neuromarkers of anxiety and depression in a patient after neuro-ophthalmic surgery of the meningioma – effect of individually-tailored tDCS and neurofeedback

Mirski

Pąchalska

Moskała³

et al. 2015

Ann Agric Environ Med.

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of anxiety and depression in a patient after neuro-ophthalmic surgery of the meningioma -effect of individually-tailored tDCS and neurofeedback. Ann Agric Environ Med. 2015; 22(4): 718-723. doi: 10.5604/12321966.1185783 AbstractThe aim of the study was to evaluate the effectiveness of individually tailored anodal tDCs/ neurofeedback protocol for the reduction of post-operative depression after a neuroophtalmological operation of the meningioma. The neuromarkers in Quantitative EEG (QEEG) and Event-related potentials (ERPs) were utilized in the construction of protocol and evaluation. Case description. A 45-year-old female after successful neuro-ophthalmic surgery of the meningioma, complained of severe pain and anxiety, difficulties with sleeping, attention and memory problems, as well as inability to continue working in her given profession. Neuropsychological testing showed lack of cognitive disturbances and post-operative depression. Two working hypotheses were tested to find neuromarkers of depression and anxiety. In line with the 'depression hypothesis' a frontal alpha asymmetry pattern was found in the patient, and in line with the 'anxiety' hypothesis an increased left temporal P1 wave in response to visual stimuli was found in ERPs. A specific alpha asymmetry neurofeedback protocol combined with an anodal tDCS was suggested. Twenty sessions of individually-tailored anodal tDCs/ neurofeedback protocol were performed. The QEEG frontal asymmetry pattern and the excessive temporal P1 wave were normalized after the intervention. Conclusions. The patient recovered from post-operative depression and returned to work after 20 sessions of the combined neurofeedback/tDCS protocol. Specific patterns of QEEG and ERPs serve as neuromarkers for constructing the protocol and for monitoring the results of intervention.

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Section: Resultssupporting

confidence: 65%

Section: Case Studymentioning

confidence: 99%

Neuromarkers of anxiety and depression in a patient after neuro-ophthalmic surgery of the meningioma – effect of individually-tailored tDCS and neurofeedback

Mirski

Pąchalska

Moskała³

et al. 2015

Ann Agric Environ Med.

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“…Disruption of paralimbic pathways linking frontal cortex in secondary depression was indicated in [71]. But the most mentioned finding was the frontal brain asymmetry [72][73][74][75], which was described with greater activation in the right compared to the left frontal lobes [76]. The asymmetric frontal cortical activity in the MDD group had been widely presented not only in alpha band but also in the theta band [24,77].…”

Section: Discussionmentioning

confidence: 99%

A Resting-State Brain Functional Network Study in MDD Based on Minimum Spanning Tree Analysis and the Hierarchical Clustering

Jing

et al. 2017

Complexity

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A large number of studies demonstrated that major depressive disorder (MDD) is characterized by the alterations in brain functional connections which is also identifiable during the brain's "resting-state." But, in the present study, the approach of constructing functional connectivity is often biased by the choice of the threshold. Besides, more attention was paid to the number and length of links in brain networks, and the clustering partitioning of nodes was unclear. Therefore, minimum spanning tree (MST) analysis and the hierarchical clustering were first used for the depression disease in this study. Resting-state electroencephalogram (EEG) sources were assessed from 15 healthy and 23 major depressive subjects. Then the coherence, MST, and the hierarchical clustering were obtained. In the theta band, coherence analysis showed that the EEG coherence of the MDD patients was significantly higher than that of the healthy controls especially in the left temporal region. The MST results indicated the higher leaf fraction in the depressed group. Compared with the normal group, the major depressive patients lost clustering in frontal regions. Our findings suggested that there was a stronger brain interaction in the MDD group and a left-right functional imbalance in the frontal regions for MDD controls.

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“…Neurobiological alterations have been described in patients with mood disorders (Cole, Costafreda, McGuffin, & Fu, 2011;Donofry, Roecklein, Wildes, Miller, & Erickson, 2016;Jesulola, Sharpley, Bitsika, Agnew, & Wilson, 2015;Mears & Pollard, 2016;Zhang et al, 2016). In this sense it has been proposed that the normalization of such alterations may represent the neurobiological correlate of treatment effects.…”

Section: Psychotherapy or Pharmacotherapy: Does The Brain Matter?mentioning

confidence: 99%

Psychological treatments are as effective as pharmacotherapies in the treatment of adult depression: a summary from Randomized Clinical Trials and neuroscience evidence

Cuijpers

Gentili

2017

ResPsy

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Frontal alpha asymmetry as a pathway to behavioural withdrawal in depression: Research findings and issues

Cited by 88 publications

References 178 publications

Neuromarkers of anxiety and depression in a patient after neuro-ophthalmic surgery of the meningioma – effect of individually-tailored tDCS and neurofeedback

Neuromarkers of anxiety and depression in a patient after neuro-ophthalmic surgery of the meningioma – effect of individually-tailored tDCS and neurofeedback

A Resting-State Brain Functional Network Study in MDD Based on Minimum Spanning Tree Analysis and the Hierarchical Clustering

Psychological treatments are as effective as pharmacotherapies in the treatment of adult depression: a summary from Randomized Clinical Trials and neuroscience evidence

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