Frontal and anterior cingulate activation during overt verbal fluency in patients with first episode psychosis

Schaufelberger, Maristela S.; Senhorini, Maurien C T; Barreiros, Maria Angela M.; Amaro, Edson; Menezes, Paulo Rossi; Scazufca, Márcia; Castro, Cláudio Campi de; Ayres, Adriana M.; Murray, Robin M.; McGuire, Philip; Busatto, Geraldo F.

doi:10.1590/s1516-44462005000300013

Cited by 31 publications

(25 citation statements)

References 33 publications

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“…There was also a significant group difference in ventrolateral prefrontal cortex, but in this region ARMS subject showed greater activation that controls. Previous studies in first episode 32,42,43 or high-risk samples 27 found both reduced and increased activation in this area during similar verbal fluency tasks relative to a baseline scan. Discrepant findings in the literature might be simply due to differences in experimental design, technical differences of fMRI data acquisition, demographic characteristics, generalized cognitive impairment, and functional heterogeneity in subjects at risk for schizophrenia or to other cofounders such as different exposure to medication, head motion, and lack of diagnostic reassessment during the follow-up.…”

Section: Discussionmentioning

confidence: 77%

Prefrontal Function at Presentation Directly Related to Clinical Outcome in People at Ultrahigh Risk of Psychosis

Fusar‐Poli

Broome

Matthíasson

et al. 2009

Schizophrenia Bulletin

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Section: Discussionmentioning

confidence: 77%

Prefrontal Function at Presentation Directly Related to Clinical Outcome in People at Ultrahigh Risk of Psychosis

Fusar‐Poli

Broome

Matthíasson

et al. 2009

Schizophrenia Bulletin

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“…Others have found SMA responses during phonation (Colebatch et al, 1991), exhalation (Colebatch et al, 1991) and speech (Murphy et al, 1997;Wise et al, 1999;Riecker et al, 2005) along with the ACC (Barrett et al, 2004;Schaufelberger et al, 2005;Schulz et al, 2005). The greater involvement of the SMA during the repetitive syllable task in contrast with prolonged vowels suggests that SMA activity may be greater during complex movements such as syllable production for speech.…”

Section: Components Of the Phonatory Systemmentioning

confidence: 99%

Human brain activation during phonation and exhalation: Common volitional control for two upper airway functions

et al. 2007

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Phonation is defined as a laryngeal motor behavior used for speech production, which involves a highly specialized coordination of laryngeal and respiratory neuromuscular control. During speech, brief periods of vocal fold vibration for vowels are interspersed by voiced and unvoiced consonants, glottal stops and glottal fricatives (/h/). It remains unknown whether laryngeal/respiratory coordination of phonation for speech relies on separate neural systems from respiratory control or whether a common system controls both behaviors. To identify the central control system for human phonation, we used event-related fMRI to contrast brain activity during phonation with activity during prolonged exhalation in healthy adults. Both whole-brain analyses and region of interest comparisons were conducted. Production of syllables containing glottal stops and vowels was accompanied by activity in left sensorimotor, bilateral temporoparietal and medial motor areas. Prolonged exhalation similarly involved activity in left sensorimotor and temporoparietal areas but not medial motor areas. Significant differences between phonation and exhalation were found primarily in the bilateral auditory cortices with whole brain analysis. The ROI analysis similarly indicated task differences in the auditory cortex with differences also detected in the inferolateral motor cortex and dentate nucleus of the cerebellum. A second experiment confirmed that activity in the auditory cortex only occurred during phonation for speech and did not depend upon sound production. Overall, a similar central neural system was identified for both speech phonation and voluntary exhalation that primarily differed in auditory monitoring. Keywords phonation; exhalation; speech; fMRI Phonation for human speech is a highly specialized manner of laryngeal sensorimotor control that extends beyond generating the sound source of speech vowels and semi-vowels (e.g. /y/ and /r/). Laryngeal gestures for voice onset and offset distinguish voiced and unvoiced consonant pairs through precise timing of voice onset (Raphael et al., 2006). Brief interruptions in phonation by glottal stops (/ʔ/) mark word and syllable boundaries through hyper-adduction of the vocal folds to offset phonation. Each of these vocal fold gestures, in addition to rapid pitch changes for intonation require precisely controlled variations in intrinsic laryngeal activity (Poletto et al., 2004). To understand the neural control of phonation for speech, laryngeal control must be investigated independent of the oral articulators (lips, tongue, jaw). Several neuroimaging studies of phonation for speech included oral articulatory movements Publisher's Disclaimer: This is a PDF file of an unedited manuscript that has been accepted for publication. As a service to our customers we are providing this early version of the manuscript. The manuscript will undergo copyediting, typesetting, and review of the resulting proof before it is published in its final citable form. Please note that during the producti...

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“…A defect in the frontolimbic system or dorsal "archicortical" trend, which encompasses both the superior frontal and anterior cingulate gyri, has been hypothesized to be critical for the stable execution of internally generated, task relevant, action-oriented behaviors (Bilder and Degreef, 1991;Bilder and Szeszko, 1996;Szeszko et al 2002). Evidence for a genetically mediated defect in this integrated system in schizophrenia could play a role in neuropsychological deficits observed during executive functioning (Szeszko et al 2000;Everett et al 2001), two-choice guessing (Paulus et al 1999), verbal fluency (Schaufelberger et al 2005) and conflict monitoring (Kerns et al 2005).…”

Section: And Healthy Volunteers (Du Boisgueheneuc Et Al 2006)mentioning

confidence: 99%

DISC1 is associated with prefrontal cortical gray matter and positive symptoms in schizophrenia

Szeszko

Hodgkinson

Robinson

et al. 2008

Biological Psychology

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Background-DISC1 is considered a susceptibility gene for schizophrenia and schizoaffective disorder, but little is known regarding the potential mechanisms through which it may confer increased risk. Given that DISC1 plays a role in cerebral cortex development, polymorphisms in this gene may have relevance for neurobiological models of schizophrenia that have implicated cortical deficits in its pathophysiology.

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Frontal and anterior cingulate activation during overt verbal fluency in patients with first episode psychosis

Cited by 31 publications

References 33 publications

Prefrontal Function at Presentation Directly Related to Clinical Outcome in People at Ultrahigh Risk of Psychosis

Prefrontal Function at Presentation Directly Related to Clinical Outcome in People at Ultrahigh Risk of Psychosis

Human brain activation during phonation and exhalation: Common volitional control for two upper airway functions

DISC1 is associated with prefrontal cortical gray matter and positive symptoms in schizophrenia

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