Frontal and Limbic Activation During Inhibitory Control Predicts Treatment Response in Major Depressive Disorder

Langenecker, Scott A.; Kennedy, Susan E.; Guidotti, Leslie; Briceño, Emily M.; Own, Lawrence S.; Hooven, Thomas A.; Young, Elizabeth A.; Akil, Huda; Noll, Douglas C.; Zubieta, Jon Kar

doi:10.1016/j.biopsych.2007.02.019

Cited by 186 publications

(174 citation statements)

References 56 publications

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“…Furthermore, optimized detection of response and remission was achieved by mapping the dynamic speed of individual treatment response with a sigmoid function. Thereby, aberrant frontal and anterior cingulate activity were confirmed as important correlates of antidepressant response [6,[15][16][17]. Finally, we detected that remission was associated with higher pretreatment TPJ activity.…”

Section: Discussionsupporting

confidence: 63%

The pulvinar nucleus and antidepressant treatment: dynamic modeling of antidepressant response and remission with ultra-high field functional MRI

et al. 2018

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Functional magnetic resonance imaging (fMRI) successfully disentangled neuronal pathophysiology of major depression (MD), but only a few fMRI studies have investigated correlates and predictors of remission. Moreover, most studies have used clinical outcome parameters from two time points, which do not optimally depict differential response times. Therefore, we aimed to detect neuronal correlates of response and remission in an antidepressant treatment study with 7 T fMRI, potentially harnessing advances in detection power and spatial specificity. Moreover, we modeled outcome parameters from multiple study visits during a 12-week antidepressant fMRI study in 26 acute (aMD) patients compared to 36 stable remitted (rMD) patients and 33 healthy control subjects (HC). During an electrical painful stimulation task, significantly higher baseline activity in aMD compared to HC and rMD in the medial thalamic nuclei of the pulvinar was detected (p = 0.004, FWE-corrected), which was reduced by treatment. Moreover, clinical response followed a sigmoid function with a plateau phase in the beginning, a rapid decline and a further plateau at treatment end. By modeling the dynamic speed of response with fMRI-data, perigenual anterior cingulate activity after treatment was significantly associated with antidepressant response (p < 0.001, FWE-corrected). Temporoparietal junction (TPJ) baseline activity significantly predicted non-remission after 2 antidepressant trials (p = 0.005, FWE-corrected). The results underline the importance of the medial thalamus, attention networks in MD and antidepressant treatment. Moreover, by using a sigmoid model, this study provides a novel method to analyze the dynamic nature of response and remission for future trials.

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Section: Discussionsupporting

confidence: 63%

The pulvinar nucleus and antidepressant treatment: dynamic modeling of antidepressant response and remission with ultra-high field functional MRI

et al. 2018

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“…Extending on this point, we might consider the present findings in the context of results for non-emotion tasks that require effortful cognition. Using a cognitive task to probe effortful inhibition, increased (rather than decreased) activation of the amygdala and regions to which it projects has been found to predict antidepressant response (Langenecker et al, 2007). In a separate study of the iSPOT-D sample, we have also observed that increased activation of the DLPFC engaged by a response inhibition task is predictive of response (Gyurak et al, 2015).…”

Section: Discussionmentioning

confidence: 68%

Amygdala Reactivity to Emotional Faces in the Prediction of General and Medication-Specific Responses to Antidepressant Treatment in the Randomized iSPOT-D Trial

Williams

Korgaonkar

Song

et al. 2015

Neuropsychopharmacol

177

125

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Although the cost of poor treatment outcomes of depression is staggering, we do not yet have clinically useful methods for selecting the most effective antidepressant for each depressed person. Emotional brain activation is altered in major depressive disorder (MDD) and implicated in treatment response. Identifying which aspects of emotional brain activation are predictive of general and specific responses to antidepressants may help clinicians and patients when making treatment decisions. We examined whether amygdala activation probed by emotion stimuli is a general or differential predictor of response to three commonly prescribed antidepressants, using functional magnetic resonance imaging (fMRI). A test-retest design was used to assess patients with MDD in an academic setting as part of the International Study to Predict Optimized Treatment in Depression. A total of 80 MDD outpatients were scanned prior to treatment and 8 weeks after randomization to the selective serotonin reuptake inhibitors escitalopram and sertraline and the serotonin-norepinephrine reuptake inhibitor, venlafaxine-extended release (XR). A total of 34 matched controls were scanned at the same timepoints. We quantified the blood oxygen level-dependent signal of the amygdala during subliminal and supraliminal viewing of facial expressions of emotion. Response to treatment was defined by ⩾ 50% symptom improvement on the 17-item Hamilton Depression Rating Scale. Pre-treatment amygdala hypo-reactivity to subliminal happy and threat was a general predictor of treatment response, regardless of medication type (Cohen's d effect size 0.63 to 0.77; classification accuracy, 75%). Responders showed hypo-reactivity compared to controls at baseline, and an increase toward 'normalization' post-treatment. Pre-treatment amygdala reactivity to subliminal sadness was a differential moderator of non-response to venlafaxine-XR (Cohen's d effect size 1.5; classification accuracy, 81%). Non-responders to venlafaxine-XR showed pre-treatment hyperreactivity, which progressed to hypo-reactivity rather than normalization post-treatment, and hypo-reactivity post-treatment was abnormal compared to controls. Impaired amygdala activation has not previously been highlighted in the general vs differential prediction of antidepressant outcomes. Amygdala hypo-reactivity to emotions signaling reward and threat predicts the general capacity to respond to antidepressants. Amygdala hyper-reactivity to sad emotion is involved in a specific non-response to a serotonin-norepinephrine reuptake inhibitor. The findings suggest amygdala probes may help inform the personal selection of antidepressant treatments.

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“…Recent reports have shown an altered emotion processing in depression compared with the healthy state concerning the perception and also the anticipation of emotional events (e.g. for reviews, see Drevets, 2001 ;Davidson et al 2002 ;Phillips et al 2003 ;Leppanen, 2006 ; for recent reports, see Keedwell et al 2005 ;Abler et al 2006 ;Johnstone et al 2007 ;Langenecker et al 2007 ; Lee et al 2007 ;Dannlowski et al 2008 ;Fales et al 2008 ;Grimm et al 2008 ;Knutson et al 2008 ;Mitterschiffthaler et al 2008). However, the direct comparison of anticipating events of known positive and negative valence with an unknown valence as a model of ' pessimistic ' expectation has not yet been performed in depressed patients.…”

Section: Introductionmentioning

confidence: 99%

Neural correlates of ‘pessimistic’ attitude in depression

et al. 2009

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Background. Preparing for potentially threatening events in the future is essential for survival. Anticipating the future to be unpleasant is also a cognitive key feature of depression. We hypothesized that ' pessimism '-related emotion processing would characterize brain activity in major depression.Method. During functional magnetic resonance imaging, depressed patients and a healthy control group were cued to expect and then perceive pictures of known emotional valences -pleasant, unpleasant and neutral -and stimuli of unknown valence that could have been either pleasant or unpleasant. Brain activation associated with the ' unknown ' expectation was compared with the ' known ' expectation conditions.Results. While anticipating pictures of unknown valence, activation patterns in depressed patients within the medial and dorsolateral prefrontal areas, inferior frontal gyrus, insula and medial thalamus were similar to activations associated with expecting unpleasant pictures, but not with expecting positive pictures. The activity within a majority of these areas correlated with the depression scores. Differences between healthy and depressed persons were found particularly for medial and dorsolateral prefrontal and insular activations.Conclusions. Brain activation in depression during expecting events of unknown emotional valence was comparable with activation while expecting certainly negative, but not positive events. This neurobiological finding is consistent with cognitive models supposing that depressed patients develop a ' pessimistic ' attitude towards events with an unknown emotional meaning. Thereby, particularly the role of brain areas associated with the processing of cognitive and executive control and of the internal state is emphasized in contributing to major depression.

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Frontal and Limbic Activation During Inhibitory Control Predicts Treatment Response in Major Depressive Disorder

Cited by 186 publications

References 56 publications

The pulvinar nucleus and antidepressant treatment: dynamic modeling of antidepressant response and remission with ultra-high field functional MRI

The pulvinar nucleus and antidepressant treatment: dynamic modeling of antidepressant response and remission with ultra-high field functional MRI

Amygdala Reactivity to Emotional Faces in the Prediction of General and Medication-Specific Responses to Antidepressant Treatment in the Randomized iSPOT-D Trial

Neural correlates of ‘pessimistic’ attitude in depression

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