Frontal Behavioural Inventory in the differential diagnosis of dementia

Milan, Graziella; Lamenza, F; Iavarone, Alessandro; Galeone, Filomena; Loré, Elisa; Falcó, Cristina; Sorrentino, Paolo; Postiglione, Alfredo

doi:10.1111/j.1600-0404.2007.00934.x

Cited by 52 publications

(37 citation statements)

References 35 publications

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“…In this study, frontal-related behaviors differentiated subjects with aMCI from early AD, which is compatible with and comparable to previous studies [Milan et al, 2007]. We found that negative behaviors were significantly associated with DTI measurement of the frontal PVWM.…”

Section: Discussionsupporting

confidence: 93%

“…The FBI is a 24-item caregiver-based behavioral questionnaire. It was originally designed for the diagnosis and quantification of frontotemporal dementia symptoms, but is also helpful in the differential diagnosis of dementia [Kertesz, 1997;Milan et al, 2007]. There were four possible response options, resulting in a total score ranging from 0 to 72: (0), mild and occasional (1), moderate (2), or serious and most of the time (3).…”

Section: Executive Function Testsmentioning

confidence: 99%

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Executive dysfunction and periventricular diffusion tensor changes in amnesic mild cognitive impairment and early Alzheimer's disease

Chen¹,

Chen²,

Cheng³

et al. 2009

Human Brain Mapping

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Our aim in this study was to explore the neural substrates of executive function in frontal and nonfrontal white matter using diffusion tensor imaging (DTI). We studied the relationship between executive dysfunction and DTI measurements on 13 subjects with amnesic mild cognitive impairment (aMCI), 11 subjects with early Alzheimer's disease (AD), and 16 control subjects. All participants underwent an examination of their intelligence, memory, and executive function and were subjected to DTI. Both aMCI and early AD subjects showed executive function impairment with differential performance in frontal-related behaviors. Both aMCI and early AD subjects showed increased mean diffusivity in the genu of the corpus callosum and left frontal periventricular white matter (PVWM), whereas subjects with early AD showed an additional decrease in the fractional anisotropy of bilateral frontal PVWM and in the genu of the corpus callosum. The frontal PVWM was associated with performance on the Verbal Fluency Test, the Wisconsin Card Sorting Test (WCST), and Part B of the Trail Making Test. The parietal PVWM was associated with perseverative errors on the WCST and Part A of the Trail Making Test. In summary, executive function was impaired in subjects with aMCI and early AD and was associated with frontal and parietal PVWM changes. These changes may be due to early AD degeneration of the lateral cholinergic projections or to early change of the superior longitudinal fasciculus.

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Section: Discussionsupporting

confidence: 93%

Section: Executive Function Testsmentioning

confidence: 99%

Executive dysfunction and periventricular diffusion tensor changes in amnesic mild cognitive impairment and early Alzheimer's disease

Chen¹,

Chen²,

Cheng³

et al. 2009

Human Brain Mapping

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“…In 2007, Blair et al [15] compared these two scales and stated that FBI discriminated better between different types of FTD In a study on 35 patients with bvFTD, Milan et al [16] also concluded that the FBI was superior to other scales. The FBI appeared to be more specific in detecting personality changes caused by frontal disorders.…”

Section: Relevance Of Npi and Fbi Scales To Establish A Diagnosis Andmentioning

confidence: 99%

Prospective Evaluation of Behavioral Scales in the Behavioral Variant of Frontotemporal Dementia

Boutoleau‐Bretonnière¹,

Lebouvier²,

Volteau³

et al. 2012

Dement Geriatr Cogn Disord

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Background: The Neuropsychiatric Inventory (NPI) and the Frontal Behavioral Inventory (FBI) are widely used in patients with the behavioral variant of frontotemporal dementia (bvFTD). Yet, few data are available on the long-term relevance of these scales. Material and Methods: Based on a bvFTD population that participated in the Memantine Clinical Trial (NCT00200538), we studied the evolution and correlation between scores obtained on behavioral scales (NPI and FBI), cognitive scales [Mini-Mental State Examination (MMSE) and Mattis Dementia Rating Scale (MDRS)] and a burden scale [Zarit Burden Inventory (ZBI)]. The assessments were performed at 1 year in 41 patients and at 2 years in 23 patients who agreed to participate in this open-label study. Results: The 2-year scores obtained on the FBI were significantly higher than the scores at inclusion while those obtained on the NPI did not change. There were significant correlations between the FBI, and the MDRS and MMSE, especially regarding the negative items. The ZBI correlated with behavioral scales at all stages for positive items. Conclusions: This study based on a large population shows that the FBI is a better tool than the NPI for the long-term assessment of bvFTD patients. Moreover, the FBI allows a distinction to be made between behavioral disturbances that involve cognitive functions from those which have an important impact on caregiver burden.

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“…New alternatives have been developed that aim to replicate daily life activities to enhance ecological validity, such as the Virtual Kitchen Test [71] . Furthermore, since in many patients disease insight is lacking due to frontal dysfunction, behavior changes can be quantified using informant-based questionnaires like the Frontal Behavioural Inventory or the Stereotypy Rating Inventory [72,73] . Krudop …”

Section: Instruments To Measure Frontal Lobe Dysfunctionmentioning

confidence: 99%

Historical Evolution of the Frontal Lobe Syndrome

Krudop¹,

Pijnenburg²

2015

Psychopathology

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The function of the frontal lobes and the related frontal lobe syndrome have not been described in detail until relatively late in history. Slowly, the combination of knowledge from animal models, the detailed examination of symptoms after traumatic frontal lobe injuries, and the rise and fall of psychosurgery has led to increasing insight into frontal lobe function. The frontosubcortical circuits have been described and increasingly related to clinical syndromes, confirmed by the latest developments in functional connectivity networks.

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Frontal Behavioural Inventory in the differential diagnosis of dementia

Abstract: The FBI is a neurobehavioral tool suitable to distinguish fv-FTD from other forms of dementia also when data from cognitive testing or other behavioral scales fail to support the differential diagnosis.

Cited by 52 publications

References 35 publications

Executive dysfunction and periventricular diffusion tensor changes in amnesic mild cognitive impairment and early Alzheimer's disease

Executive dysfunction and periventricular diffusion tensor changes in amnesic mild cognitive impairment and early Alzheimer's disease

Prospective Evaluation of Behavioral Scales in the Behavioral Variant of Frontotemporal Dementia

Historical Evolution of the Frontal Lobe Syndrome

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