Introduction: fibro-osseous lesions of the jaws comprise a diverse group of pathological conditions characterized by the replacement of bone with newly formed mineralized fibrous tissue. Fibrous dysplasia (FD) is a tumor-like developmental anomaly caused by a congenital mutation in the GNAS gene, leading to the replacement of bone with fibrous connective tissue containing irregular bony trabeculae. The application of piezoelectric technology in oral bone surgery is highly advantageous, including precise and selective hard tissue cutting, preservation of vital structures, improved surgical field visibility, and reduced post-operative discomfort for patients.Material and Methods: Herein, we present a case series involving two patients that referred to Galliera Hospital (Genoa, Italy), with an expansive mass involving the right upper jaw (Case 1) and the left side of the mandible (Case 2). Piezoelectric instrumentation was used for incisional biopsies, after the elevation of a flap to expose the lesion.Results: histopathological examination confirmed the diagnosis of FD, and conservative management was opted due to the benign nature of the condition.
Conclusion:given the benign nature of the diagnosed condition and the absence of patient discomfort or facial deformities, literature suggests regular annual check-ups as surgical treatment is not requested. The application of piezoelectric instruments proved to be a valid and effective method.