Frontal Fibrosing Alopecia

Abstract

Frontal fibrosing alopecia, described simply over two decades in the past, has come to be probably the most normally noticeable causes of scarring phalacrosis at several skilled hair clinics. Regarded a medical variant of lichen planopilaris (LPP), its uncommon components and associations that distinguish it from LPP. Despite the fact that largely affecting post-menopausal ladies, a small however growing number of guys and premenopausal ladies are affected. The spectrum of the ailment has accelerated from involvement of the frontal hairline and eyebrows, to potentially affecting the whole hairline, facial and body hair. Genetic and environmental motives were implicated however the aetiology remains uncertain. A range of cures had been used in management of the, however medical trials are required to set up effectiveness.

Examination of Clinical and Demographic Characteristics of 14 Cases with Frontal Fibrosing Alopecia

“…Symptoms such as itching, burning and pain are seen less compared to lichen planopilaris. Itching on FFA area was reported in 3-67% of the cases in the literature (4,6,11,13,15). Itching was present in 21% of the cases (3 cases).…”

“…Another opinion regarding FFA ethiopathogenesis is the effect of androgen hormonal factors. While the facts that it usually affects postmenopausal women, involves frontal scalp, and responds to antiandrogens such as finasteride or dutasteride in some patients suggest this, a significant relationship is yet to be revealed (4,9,24). Today, FFA is regarded as a clinical variant of LPP which has selectivity for frontotemporal hairline, primarily affects postmenopausal women and is characterized by lymphocytic cicatricial alopecia (2,3,17).…”

“…Itching was present in 21% of the cases (3 cases). While the ethiopathogenesis of the FFA is not exactly known, the key role is thought be played by T-cell mediated autoimmune reaction against hair follicles (2,(3)(4)(5)9,16). Another opinion regarding FFA ethiopathogenesis is the effect of androgen hormonal factors.…”

“…All our cases had cicatricial alopecia. FFA is disease of postmenopausal women by 95%, and the mean onset age of the disease is 67 (45-82) (2,3,4). A multi-center study performed by Vano et al, is the study including the largest series with 355 patients on this subject (14).…”

“…Histopathological examination is supportive in diagnosis (2,5,7). While the pathogenesis is not exactly known, its everincreasing incidence in recent years indicates possible involvement of environmental factors (4). On the other hand, the fact that FFA is seen in more than one individual in some families suggests genetic factors yet to be discovered (8).…”