Frontal fibrosing alopecia: A review of disease pathogenesis

Miao, Yujie; Jing, Jing; Du, Xuewen; Mao, Mei-Qi; Yang, Xiaoshuang; Lv, Zhongfa

doi:10.3389/fmed.2022.911944

Cited by 11 publications

(21 citation statements)

References 53 publications

(67 reference statements)

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“…Etiopatogeneza FFA jest wieloczynnikowa i nadal nie w pełni poznana [21][22][23]. W artykule dokonano przeglądu najnowszych doniesień dotyczących możliwych czynników wywołujących FFA ze szczególnym uwzględnieniem potencjalnego znaczenia etiologicznego substancji zawartych w preparatach kosmetycznych.…”

Section: Wprowadzenieunclassified

“…The etiopathogenesis of FFA is multifactorial and still not fully understood [21][22][23]. The article reviews the latest reports on potential factors causing FFA, with particular emphasis on the potential etiological significance of substances contained in cosmetic products.…”

Section: Wprowadzeniementioning

confidence: 99%

“…Silny stres uznawany jest za jeden z czynników wywołujących łysienie plackowate, a także w przypadku FFA za czynnik, który może przyspieszyć proces utraty włosów [23]. Przeprowadzone doświadcze-Dermatology Review/Przegląd Dermatologiczny 2022/6 coid lupus erythematosus (DLE), rheumatoid arthritis and polymyositis [34].…”

Section: Czynniki Autoimmunologiczne I Choroby Współistniejąceunclassified

“…Strong stress is considered one of the factors causing alopecia areata, and in the case of FFA, as a factor that can accelerate the process of hair loss [23]. Preclinical experiments performed in a murine model have shown that stress stimulation can induce neurogenic inflammation around hair follicles, increase mast cell degranulation and produce inhibitory factors such as substance P [43].…”

Section: Czynniki Autoimmunologiczne I Choroby Współistniejącementioning

confidence: 99%

“…Ramos et al identified haplotypes -C*17:01:01:02/B*42:01:01:01 and C*07:02:01:03/B*07:02:01:01, which occurred more often in both sporadic and familial cases of FFA [45,46]. The B*07:02 allele has also been described as a risk factor for FFA [23].…”

Section: Genetic Factorsmentioning

confidence: 99%

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Potential etiological factors in frontal fibrosing alopecia

Maciejewska¹,

Czuwara²,

Dąbrowska³

et al. 2022

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Frontal fibrosing alopecia is a variant of lichen planus, leading to permanent hair loss from the frontal hairline. It occurs mainly in postmenopausal women, however, the role of hormonal factors in the pathogenesis of this type of alopecia has not been determined. The coexistence of frontal fibrosing alopecia and autoimmune diseases is observed, e.g., hypothyroidism, rheumatoid arthritis, vitiligo, polymyositis, systemic lupus erythematosus and discoid lupus erythematosus. Considering the possible role of genetic factors, research is underway to identify human leukocyte antigen (HLA) polymorphisms. One of the most studied factors is sunscreen, widely used in cosmetic products. The data available so far in this regard are controversial. Factors raising significant doubts include: the retrospective nature of the research, basing the collected data on the self-assessment of respondents and the lack of specification of the ingredients of these products. In the light of current data, sunscreen components cannot be considered as a factor playing a role in the pathogenesis of frontal fibrosing alopecia. Overestimation of the role of sunscreens in hair loss could lead to unjustified avoidance of their use and contribute to increased incidence of skin cancer.

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Section: Wprowadzenieunclassified

Section: Wprowadzeniementioning

confidence: 99%

Section: Czynniki Autoimmunologiczne I Choroby Współistniejąceunclassified

Section: Czynniki Autoimmunologiczne I Choroby Współistniejącementioning

confidence: 99%

Section: Genetic Factorsmentioning

confidence: 99%

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Potential etiological factors in frontal fibrosing alopecia

Maciejewska¹,

Czuwara²,

Dąbrowska³

et al. 2022

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Cardiovascular risk in patients with scarring and nonscarring alopecias: Assessing the current state of evidence

Sally,

Robinson,

Orlow

et al. 2023

JEADV Clinical Practice

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Alopecia is traditionally classified into scarring and nonscarring subtypes, with etiopathologies ranging from androgen‐mediated to immuno‐inflammatory. Over 50% of men and almost 50% of women will experience some form of hair loss in their lifetime. Given this prevalence and the psychosocial significance of hair, understanding the pathophysiology and comorbidities of different types of hair loss is imperative. Other proinflammatory dermatologic disorders, such as psoriasis, are recognised to have systemic manifestations including an increased risk of cardiovascular (CV) disease, and are now considered CV risk‐enhancing conditions. With increased recognition of the importance of systemic inflammation in promoting atherosclerosis, high prevalence, and improved treatment strategies, there is increased interest in establishing whether a similar association between alopecia and cardiovascular disease (CVD) exists. In this manuscript, we aim to review the current literature regarding CV risk in androgenic alopecia (AGA) and alopecia areata (AA). Additionally, we review the literature for cicatricial alopecias and highlight the need for more research into their potential associations with CV risk. Evidence from the identified AGA publications suggests an association of AGA with CV risk factors including hypertension, dyslipidemia, and insulin resistance, as well as with coronary artery disease. For AA, most of the identified studies found an association between AA and CV risk, though the relationships were not always statistically significant. Research on cicatricial alopecias and CV risk is limited and often contradictory. There is great need for more studies regarding the association between various types of alopecia and the development of CVD, and potential mechanisms. Particularly needed are more studies of cicatricial alopecias and potential associated CV risk. While some literature suggests that patients with alopecia have an increased risk of CVD, the lack of concrete evidence represents a notable gap in our current understanding.

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