Frontal lesions impair the attentional control of movements during motor learning

Richer, François; Chouinard, Marie-Josée; Rouleau, Isabelle

doi:10.1016/s0028-3932(99)00029-9

Cited by 27 publications

(17 citation statements)

References 44 publications

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“…These results are similar to what was observed in patients with frontal cortex lesions (Richer et al, 1999). The problem is more pronounced when error feedback is more essential and it is reduced with practice.…”

Section: Discussionsupporting

confidence: 90%

Early Huntington’s disease affects movements in transformed sensorimotor mappings

Boulet

Lemay

Bédard

et al. 2005

Brain and Cognition

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Section: Discussionsupporting

confidence: 90%

Early Huntington’s disease affects movements in transformed sensorimotor mappings

Boulet

Lemay

Bédard

et al. 2005

Brain and Cognition

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“…Reaching automaticity can take days, weeks, or even years. There are several possibilities which may explain the involvement of PFC in learning, including attention-demanding sensory processing, suppression of preferred isochronous tendencies, and the necessity to continuously update the movement plan based on error processing (Doyon et al 1996;Richer et al 1999;Shadmehr and Holcomb 1999;Thoenissen et al 2002;Puttemans et al 2005;Mars et al 2008;Remy et al 2010).…”

Section: Discussionmentioning

confidence: 99%

Microstructural organization of corpus callosum projections to prefrontal cortex predicts bimanual motor learning

Sisti¹,

Geurts²,

Gooijers³

et al. 2012

Learn. Mem.

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The corpus callosum (CC) is the largest white matter tract in the brain. It enables interhemispheric communication, particularly with respect to bimanual coordination. Here, we use diffusion tensor imaging (DTI) in healthy humans to determine the extent to which structural organization of subregions within the CC would predict how well subjects learn a novel bimanual task. A single DTI scan was taken prior to training. Participants then practiced a bimanual visuomotor task over the course of 2 wk, consisting of multiple coordination patterns. Findings revealed that the predictive power of fractional anisotropy (FA) was a function of CC subregion and practice. That is, FA of the anterior CC, which projects to the prefrontal cortex, predicted bimanual learning rather than the middle CC regions, which connect primary motor cortex. This correlation was specific in that FA correlated significantly with performance of the most difficult frequency ratios tested and not the innately preferred, isochronous frequency ratio. Moreover, the effect was only evident after training and not at initiation of practice. This is the first DTI study in healthy adults which demonstrates that white matter organization of the interhemispheric connections between the prefrontal structures is strongly correlated with motor learning capability.

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“…The parietal cortex and frontal motor areas are linked by cortico-cortical connections, as well as by a subcortical pathway through the cerebellum (Glickstein, 2000). The frontal cortex has a critical role in the attentional control of unpracticed movements (Richer et al, 1999). Involvement of the prefrontal region has been shown to increase with increasing attention load during visuomotor action (Chaminade & Fonlupt, 2003).…”

Section: Discussionmentioning

confidence: 99%

Visuomotor control in survivors of childhood acute lymphoblastic leukemia treated with chemotherapy only

Buizer

Sonneville

Heuvel‐Eibrink

et al. 2005

J. Inter. Neuropsych. Soc.

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Treatment for childhood acute lymphoblastic leukemia (ALL), which includes CNS prophylaxis, is associated with central and peripheral neurotoxicity. The purpose of the present study was to analyze the effects of chemotherapy on various levels of visuomotor control in survivors of childhood ALL treated without cranial irradiation, and to identify risk factors for possible deficits. Visuomotor function was compared between children after treatment for ALL (n 5 34), children after treatment for Wilms tumor, which consists of non-CNS directed chemotherapy (n 5 38), and healthy controls (n 5 151). Three tasks were administered: a simple visual reaction time task and two tasks measuring visuomotor control with one requiring a higher level of cognitive control than the other. Visuomotor deficits were detected only in the ALL group, with poorer performance restricted to the condition requiring the highest level of control. Significant risk factors for poorer performance were female gender and a short time since end of treatment, and a trend was found for a young age at diagnosis. A high cumulative methotrexate dose was an adverse predictive factor in girls. The results indicate that chemotherapy-induced central neurotoxicity in childhood ALL treatment is associated with higher order visuomotor control deficits. Girls appear to be particularly vulnerable. (JINS, 2005, 11, 554-565.)

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Frontal lesions impair the attentional control of movements during motor learning

Cited by 27 publications

References 44 publications

Early Huntington’s disease affects movements in transformed sensorimotor mappings

Early Huntington’s disease affects movements in transformed sensorimotor mappings

Microstructural organization of corpus callosum projections to prefrontal cortex predicts bimanual motor learning

Visuomotor control in survivors of childhood acute lymphoblastic leukemia treated with chemotherapy only

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