Frontal lobe dysfunction as a predictor of depression and anxiety following temporal lobe epilepsy surgery

Pope, Rebecca; Thompson, Pamela J.; Rantell, Khadija; Stretton, Jason; Wright, Mary-Anne; Foong, J

doi:10.1016/j.eplepsyres.2019.03.003

Cited by 16 publications

(9 citation statements)

References 78 publications

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“…While the CANTAB does not have an extensive research base in epilepsy [ 26 ], it has been used widely in other neurological conditions and is sensitive to frontal and temporal lobe dysfunction [ 27 ]. We include the following measures from the CANTAB: Spatial Working Memory: a measure of spatial working memory; shown to predict postoperative psychological outcomes in epilepsy [ 28 ]. Rapid Visual Information Processing: a measure of information processing speed and sustained attention; computerised assessment of sustained attention has been recommended for large scale epilepsy research [ 29 ].…”

Section: Selecting Epilepsy-relevant Tools For Telenpmentioning

confidence: 99%

“…Spatial Working Memory: a measure of spatial working memory; shown to predict postoperative psychological outcomes in epilepsy [ 28 ].…”

Section: Selecting Epilepsy-relevant Tools For Telenpmentioning

confidence: 99%

“…• Spatial Working Memory: a measure of spatial working memory; shown to predict postoperative psychological outcomes in epilepsy [28]. • Rapid Visual Information Processing: a measure of information processing speed and sustained attention; computerised assessment of sustained attention has been recommended for large scale epilepsy research [29].…”

Section: Test Of Premorbid Functioningmentioning

confidence: 99%

See 2 more Smart Citations

Teleneuropsychology in the time of COVID-19: The experience of The Australian Epilepsy Project

Tailby¹,

Collins²,

Vaughan³

et al. 2020

Seizure

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Highlights TeleNP represents a medium through which clinical research and important clinical care can continue. We discuss benefits, challenges, and practical considerations in the use of teleNP. We describe how the Australian Epilepsy Project has adapted to the COVID-19 environment. TeleNP data acquired to date reveals deficits typical of those observed in epilepsy. TeleNP presents an opportunity to expand the reach and breadth of neuropsychological services.

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Section: Selecting Epilepsy-relevant Tools For Telenpmentioning

confidence: 99%

“…Spatial Working Memory: a measure of spatial working memory; shown to predict postoperative psychological outcomes in epilepsy [ 28 ].…”

Section: Selecting Epilepsy-relevant Tools For Telenpmentioning

confidence: 99%

Section: Test Of Premorbid Functioningmentioning

confidence: 99%

See 1 more Smart Citation

Teleneuropsychology in the time of COVID-19: The experience of The Australian Epilepsy Project

Tailby¹,

Collins²,

Vaughan³

et al. 2020

Seizure

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show abstract

“…Lines of evidence have reported that the activity of the parahippocampal gyrus is involved in the regulation of sensory memory. 16–18 Davies et al reported that anxiety is associated with the abnormal activation of the parahippocampal gyrus. 19 Cannabidiol, which had anxiolytic effects, augmented the activation of the parahippocampal gyrus in patients with anxiety compared to placebo.…”

Section: Discussionmentioning

confidence: 99%

Effects of Acupuncture at Neiguan in Neural Activity of Related Brain Regions: A Resting-State fMRI Study in Anxiety

Li¹,

Wang²,

Li³

et al. 2022

NDT

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Background Acupuncture of PC6 points has the effects of calming, tranquilizing, regulating qi, and relieving pain and has been clinically found to alleviate anxiety disorders. To explore the mechanism of improvement at the Neiguan point acupuncture in anxiety patients, we used fMRI to observe the changes in brain function in patients with immediate anxiety before and after acupuncture at the Neiguan point. Subjects and Methods The experiment followed the principle of randomized, single-blind design. Twenty-four anxiety volunteers (14 males and 10 females, 20–35 years old) were divided randomly into two groups: a group of acupuncture at Neiguan and a group of acupuncture at non-acupoint. Functional magnetic resonance imaging (fMRI) was applied to measure brain activity pre- and post-acupuncture. The amplitude of low-frequency fluctuations (ALFF) and seed-based functional connectivity (FC) was used to analyze the activity and network of brain regions. Statistical analysis was done using SPSS 21.0 and REST 1.8 software. Results ALFF results revealed that post-acupuncture at Neiguan increased the activity of the left parahippocampal gyrus, fusiform gyrus, and right superior temporal gyrus and decreased the activity of the right middle frontal gyrus, right precuneus, and cuneus. Post-acupuncture at non-acupoint led to a significant ALFF increase in the thalamus and middle frontal gyrus. The ALFF in the left middle frontal gyrus was decreased. Functional connectivity in several anterior default mode network (DMN) regions and vermis cerebelli at left parahippocampal/fusiform gyri was increased, and connectivity in bilateral superior temporal gyri was decreased. FC with posterior DMN regions decreased at the right middle frontal gyrus, right precuneus, and cuneus. Conclusion Our study elucidates that acupuncture at Neiguan modulates anxiety by activating or deactivating these brain anxiety-related regions and provides potential explanations for the application of PC6 acupuncture in mental diseases.

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“…In neuroimaging studies, epileptic patients drug-resistant with anxiety show an enlargement of the amygdala ( Satishchandra et al, 2003 ). However, other limbic structures such as the prefrontal cortex seem to be involved in anxiety ( Pope et al, 2019 ). Epileptic patients with foci in the frontal areas show anxiety symptoms as well ( Tang et al, 2012 ).…”

Section: Psychiatric Comorbidities In Epilepsymentioning

confidence: 99%

Parvalbumin Role in Epilepsy and Psychiatric Comorbidities: From Mechanism to Intervention

Godoy

Prizon

Rossignoli

et al. 2022

Front. Integr. Neurosci.

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Parvalbumin is a calcium-binding protein present in inhibitory interneurons that play an essential role in regulating many physiological processes, such as intracellular signaling and synaptic transmission. Changes in parvalbumin expression are deeply related to epilepsy, which is considered one of the most disabling neuropathologies. Epilepsy is a complex multi-factor group of disorders characterized by periods of hypersynchronous activity and hyperexcitability within brain networks. In this scenario, inhibitory neurotransmission dysfunction in modulating excitatory transmission related to the loss of subsets of parvalbumin-expressing inhibitory interneuron may have a prominent role in disrupted excitability. Some studies also reported that parvalbumin-positive interneurons altered function might contribute to psychiatric comorbidities associated with epilepsy, such as depression, anxiety, and psychosis. Understanding the epileptogenic process and comorbidities associated with epilepsy have significantly advanced through preclinical and clinical investigation. In this review, evidence from parvalbumin altered function in epilepsy and associated psychiatric comorbidities were explored with a translational perspective. Some advances in potential therapeutic interventions are highlighted, from current antiepileptic and neuroprotective drugs to cutting edge modulation of parvalbumin subpopulations using optogenetics, designer receptors exclusively activated by designer drugs (DREADD) techniques, transcranial magnetic stimulation, genome engineering, and cell grafting. Creating new perspectives on mechanisms and therapeutic strategies is valuable for understanding the pathophysiology of epilepsy and its psychiatric comorbidities and improving efficiency in clinical intervention.

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Frontal lobe dysfunction as a predictor of depression and anxiety following temporal lobe epilepsy surgery

Cited by 16 publications

References 78 publications

Teleneuropsychology in the time of COVID-19: The experience of The Australian Epilepsy Project

Teleneuropsychology in the time of COVID-19: The experience of The Australian Epilepsy Project

Effects of Acupuncture at Neiguan in Neural Activity of Related Brain Regions: A Resting-State fMRI Study in Anxiety

Parvalbumin Role in Epilepsy and Psychiatric Comorbidities: From Mechanism to Intervention

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