Frontal P300 decrements, alcohol dependence, and antisocial personality disorder

Costa, Laura; Bauer, Lance O.; Kuperman, Samuel; Porjesz, Bernice; O’Connor, Sean; Hesselbrock, Victor; Rohrbaugh, John; Begleiter, Henri

doi:10.1016/s0006-3223(99)00317-0

Cited by 138 publications

(107 citation statements)

References 57 publications

Supporting

Mentioning

Contrasting

Unclassified

Order By: Relevance

“…Twin research studies have yielded evidence of common genetic factors underlying pairs of disorders within this spectrum (Grove et al, 1990;Pickens, Svikis, McGue, & LaBuda, 1995;Slutske et al, 1998). Moreover, recent large-scale epidemiological studies with twins have shown that the broad externalizing factor, reflecting the shared variance among disorders of this type, is substantially (>80%) heritable (Kendler, Prescott, Myers, & Neale, 2003;Krueger et al, 2002;Young, Stallings, Corley, Krauter, & Hewitt, 2000).Of particular relevance to the current study is growing evidence that reduced P300 response is associated with other disorders in the externalizing spectrum besides alcohol dependence, including drug dependence (Attou, Figiel, & Timsit-Berthier, 2001;Biggins, MacKay, Clark, & Fein, 1997;Branchey, Buydens-Branchey, & Horvath, 1993), nicotine dependence (Anokhin et al, 2000;Iacono et al, 2002), child conduct disorder (Bauer & Hesselbrock, 1999a, 1999bKim, Kim, & Kwon, 2001), and adult antisocial personality Costa et al, 2000). Furthermore, reduced P300 is associated with risk for these other disorders as well as with active symptoms.…”

mentioning

confidence: 67%

P300 amplitude as an indicator of externalizing in adolescent males

et al. 2006

View full text Add to dashboard Cite

Reduced P300 amplitude is reliably found in individuals with a personal or family history of alcohol problems. However, alcoholism is part of a broader externalizing spectrum that includes other substance use and antisocial disorders. We hypothesized that reduced P300 is an indicator of the common factor that underlies disorders within this spectrum. Community males (N=969) were assessed at age 17 in a visual oddball task. Externalizing was defined as the common factor underlying symptoms of alcohol dependence, drug dependence, nicotine dependence, conduct disorder, and adult antisocial behavior. A robust association was found between reduced P300 amplitude and the externalizing factor, and this relation accounted for links between specific externalizing disorders and P300. Our findings indicate that reduced P300 amplitude is an indicator of the broad neurobiological vulnerability that underlies disorders within the externalizing spectrum. Descriptors P300; externalizing; psychopathologyDiagnostic comorbidity studies and behavioral genetic investigations over the past decade have converged on the idea that alcoholism, drug dependence, and antisocial deviance in childhood and later life comprise a spectrum of related disorders. Coincident with these developments, evidence has accumulated that reduced amplitude of the P300 brain potential response, long known to be an indicator of risk for alcohol problems, is associated with other disorders in this spectrum. The current study addressed the following basic question, arising from these existing lines of evidence: Is reduced P300 amplitude an indicator of the general factor that these disorders have in common, rather than of specific disorders within this spectrum?It is well established that reduced amplitude of the P300 component of the event-related potential, a positive brainwave deflection evoked by infrequent, task-relevant events in a stimulus sequence, is associated with alcohol problems and alcoholism risk. 1 This link was first noted in work comparing abstinent alcoholics with controls (Porjesz, Begleiter, & Garozzo, 1980). Subsequent studies revealed that reduced P300 amplitude was associated not just with active symptoms, but also with risk for the development of alcohol problems. For example, children and adolescents with a paternal history of alcoholism show reliably reduced P300 compared with family-negative controls (Begleiter, Porjesz, Bihari, & Kissin, 1984;Elmasian, Neville, Woods, Schuckit, & Bloom, 1982;Hill & Shen, 2002; for review, see Address reprint requests to: Christopher J. Patrick, Department of Psychology, University of Minnesota, Elliott Hall, 75 East River Road, Minneapolis, MN 55455, USA; E-mail: cpatrick@tc.umn.edu. 1 The term P3b is sometimes used for this frequency-sensitive component, to distinguish it from the "P3a" or "novelty P3," maximal at fronto-central sites, which follows the occurrence of an unexpected rare nontarget stimulus (Coles & Rugg, 1995). Unless otherwise specified, "P300" here refers to the P3b compo...

show abstract

mentioning

confidence: 67%

P300 amplitude as an indicator of externalizing in adolescent males

et al. 2006

View full text Add to dashboard Cite

show abstract

“…In substance dependence diminished EFs have been found [12][13][14], as well as abnormalities in brain structures and functions of the prefrontal cortices and connecting circuits [15][16][17][18][19]. In impulse control disorders with a childhood onset, such as attention deficit hyperactivity disorder (ADHD) and Tourette syndrome (TS), studies indicate that diminished EFs are present [20][21][22][23], and abnormalities in brain structures and functions involved in EFs are present [21,24,25].…”

Section: Introductionmentioning

confidence: 99%

Neurocognitive functions in pathological gambling: a comparison with alcohol dependence, Tourette syndrome and normal controls

et al. 2006

View full text Add to dashboard Cite

Aims Neurocognitive functions in pathological gambling have relevance for the aetiology and treatment of this disorder, yet are poorly understood. This study therefore investigated neurocognitive impairments of executive functions in a group of carefully screened Diagnostic and Statistical Manual version IV (DSM-IV-TR) pathological gamblers. Performance was compared to a group of normal control participants. To study the specificity of these neurocognitive deficits, a substance dependence group (alcohol dependence) and an impulse control disorder group (Tourette syndrome) were included. Design Cross-sectional study. Setting Addiction and general mental health treatment centres. Participants Forty-nine pathological gamblers, 48 abstinent alcohol-dependent patients, 46 participants with Tourette syndrome and 49 normal control participants. Measurements A comprehensive neuropsychological battery measuring executive functions as well as basic cognitive functions. Findings Both the pathological gambling and the alcohol dependent groups were characterized by diminished performance on inhibition, time estimation, cognitive flexibility and planning tasks. The Tourette syndrome group showed deficits only on inhibition tasks. Basic cognitive functions were intact in all clinical groups. Comorbid attention deficit hyperactivity disorder, antisocial personality disorder and nicotine dependence influenced the impaired functions of the clinical groups only minimally. Conclusions Carefully screened groups of pathological gamblers and alcohol dependents were characterized by diminished executive functioning, suggesting a dysfunction of frontal lobe circuitry in these disorders. The resemblance between the pathological gambling group and the alcohol dependence group suggests a common neurocognitive aetiology for these disorders. Psychosocial treatment of these disorders could benefit from assessing and targeting deficits in executive functions, as they probably influence the course of these disorders negatively.

show abstract

“…Bauer and colleagues have shown that adult males with APD exhibit reduced P300 amplitude during visual oddball tasks (Bauer, 1997;O'Connor, Bauer, Tasman, & Hesselbrock, 1994). Furthermore, P300 amplitude correlates negatively with APD symptom counts and retrospectively assessed CD symptoms (Costa et al, 2000). Reductions in P300 amplitude have also been reported among adolescents with CD in both auditory (Bauer & Hesselbrock, 2003) and visual oddball tasks (Bauer & Hesselbrock, 1999a;Iacono, Carlson, Malone, & McGue, 2002;Iacono, Malone, & McGue, 2003) as well as the Stroop task (Bauer & Hesselbrock, 1999b).…”

mentioning

confidence: 97%

Violent offending predicts P300 amplitude

Bernat

Hall

Steffen

et al. 2007

International Journal of Psychophysiology

View full text Add to dashboard Cite

Prior work has consistently revealed a relationship between antisocial behavior and reduced P300 amplitude. Fewer studies have directly evaluated behavioral indices of aggression and P300, and those that have generally do not account for potential mediating variables such as age, intelligence, and behavioral task performance. The current study assessed the relationship between the total number of convicted violent and non-violent offenses and P300 in a sample of inmates from a medium security state prison. Violent offenses evidenced a robust negative relationship with P300 amplitude, whereas non-violent offenses did not. Additional analyses evaluated age, intelligence, and behavioral task performance as potential mediating variables. Only reaction time significantly predicted P300 amplitude, and mediational analyses showed that this relationship did not account for the violentoffense/P300 relationship. Findings are discussed in terms of personality correlates and neurobiological process related to aggression.There is long-standing interest in the notion that antisocial behavior, and aggression in particular, involves neurobiologically-based deficits in information processing. Neuropsychological research has revealed that antisocial behavior is associated with impaired executive function (c.f. Morgan & Lilienfeld, 2000), and neuroimaging studies have consistently identified frontal lobe abnormalities among violent offenders (Goyer, Andreason, Semple, & Clayton, 1994;Raine, Buchsbaum, & LaCasse, 1997;Raine, Lencz, Bihrle, LaCasse, Colletti, 2000; Volkow, Tancredi, Lawrence, Grant, Gillespie, & Hampton, 1995). Furthermore, research using event-related brain potentials has indicated that antisocial behavior is associated with reduced P300 responses to task-relevant stimuli in target detection tasks (e.g., Iacono, Malone, & McGue, 2003). These deficits may reflect inefficient neural processing of salient environmental stimuli (Donchin & Coles, 1988), which could potentially contribute to risk for antisocial deviance.Notably, antisocial behavior encompasses both violent and nonviolent transgressions. One unresolved issue is whether P300 amplitude is associated with both violent and non-violent forms of antisocial behavior, or more predominantly with aggressive forms of acting out. Some research has examined P300 response in aggressive individuals specifically (e.g., Barratt, Stanford, Kent, & Felthous, 1997); this work has revealed that reduced P300 amplitude is selectively related to impulsive, but not instrumental, aggression. However, this work has not compared associations for aggressive versus non-aggressive offending behavior. Thus, the aim of the present study was to replicate and extend prior research on antisocial behavior and brain response by examining relations between violent and non-violent offenses and P300 amplitude in a sample of adult male inmates. Our prediction was that reduced P300 response would be Correspondence may be addressed either to Edward M. Bernat (email: ebernat@umn.edu) or Chri...

show abstract

Frontal P300 decrements, alcohol dependence, and antisocial personality disorder

Cited by 138 publications

References 57 publications

P300 amplitude as an indicator of externalizing in adolescent males

P300 amplitude as an indicator of externalizing in adolescent males

Neurocognitive functions in pathological gambling: a comparison with alcohol dependence, Tourette syndrome and normal controls

Violent offending predicts P300 amplitude

Contact Info

Product

Resources

About