Frontal, Sensorimotor, and Posterior Parietal Regions Are Involved in Dual-Task Walking After Stroke

Lim, Shannon B.; Peters, Sue; Yang, Chieh-ling; Boyd, Lara A.; Liu‐Ambrose, Teresa; Eng, Janice J.

doi:10.3389/fneur.2022.904145

Cited by 16 publications

(9 citation statements)

References 67 publications

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“…The right PoCG, similar to the right cerebellum VIIIa, was also responsible for somatic sensory functions, which suggested that sensorimotor function might play an important role in the GBD of CSVD patients. In a previous study, stroke patients with sensorimotor deficits were more likely to experience a severe loss of postural control ( Lim et al, 2022 ). In the elderly, overactivation of the sensorimotor network may be indicative of compensatory processes for poor gait performance ( Di Scala et al, 2019 ).…”

Section: Discussionmentioning

confidence: 97%

Altered neuroimaging patterns of cerebellum and cognition underlying the gait and balance dysfunction in cerebral small vessel disease

Mao²,

Yang³

et al. 2023

Front. Aging Neurosci.

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BackgroundThe mechanism of gait and balance dysfunction (GBD) in cerebral small vessel disease (CSVD) remains unclear. Evidence supports cognition engages in GBD of CSVD. The cerebellum is important in motor and cognition, while little is known about the influence of the cerebellum on GBD in CSVD.MethodsThis study is a retrospective cohort study. All participants of this study were enrolled from the CSVD individuals in Nanjing Drum Tower Hospital from 2017 to 2021. The GBD of CSVD patients was defined as Tinetti Test score ≤ 23. Cerebral cortical thickness, cerebellar gray matter volume, the amplitude of low-frequency fluctuation, functional connectivity, and modular interaction were calculated to determine the cortical atrophy and activity patterns of CSVD patients with GBD. The effect of cognitive domains during GBD in CSVD patients was explored by correlation analyses.ResultsA total of 25 CSVD patients were recruited in CSVD patients with GBD group (Tinetti Test score ≤ 23, mean age ± standard deviation: 70.000 ± 6.976 years), and 34 CSVD patients were recruited in CSVD patients without GBD group (Tinetti Test score > 23, mean age ± standard deviation: 64.029 ± 9.453 years). CSVD patients with GBD displayed worse cognitive performance and cortical atrophy in the right cerebellum VIIIa and bilateral superior temporal gyrus than those without GBD. The right postcentral gyrus, left inferior temporal gyrus, right angular gyrus, right supramarginal gyrus and right middle frontal gyrus were functionally overactivated and showed decreased modular interaction with the right cerebellum. Tinetti Test scores were negatively related to the volume of the right cerebellum VIIIa in CSVD patients with GBD. Notably, memory, especially visuospatial memory, was greatly associated with GBD in CSVD.ConclusionThe cortical atrophy and altered functional activity in sensorimotor area and ventral attention network in the cerebellum and cerebrum may underlying the GBD in CSVD. Memory might be critically cognitively responsible for GBD in CSVD.

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Section: Discussionmentioning

confidence: 97%

Altered neuroimaging patterns of cerebellum and cognition underlying the gait and balance dysfunction in cerebral small vessel disease

Mao²,

Yang³

et al. 2023

Front. Aging Neurosci.

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“…Two of them found that step speed and length were decreased, cortical activation of PFC ( Orcioli-Silva et al, 2021 ) and SMA ( Pelicioni et al, 2022 ) were increased under obstacle negotiation dual-task conditions compared with single task condition. Three of them found step speed was decreased, cortical activation of PFC ( Hawkins et al, 2018 ; Collett et al, 2021 ; Lim et al, 2022a ), SMC ( Lim et al, 2022a ), and PMC ( Lim et al, 2022a ) were increased in stroke patients during walking under dual-task conditions compared with single-task condition ( Collett et al, 2021 ; Lim et al, 2022a ) or compared with healthy older adults ( Hawkins et al, 2018 ). Two studies of MS patients found that step speed was decreased and cortical activation of PFC was increased under dual-task conditions ( Hernandez et al, 2016 ) during walking compared to healthy older adults ( Chaparro et al, 2017 ).…”

Section: Resultsmentioning

confidence: 99%

Relationship between motor performance and cortical activity of older neurological disorder patients with dyskinesia using fNIRS: A systematic review

Dong

Tang

et al. 2023

Front. Physiol.

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Background: Neurological disorders with dyskinesia would seriously affect older people’s daily activities, which is not only associated with the degeneration or injury of the musculoskeletal or the nervous system but also associated with complex linkage between them. This study aims to review the relationship between motor performance and cortical activity of typical older neurological disorder patients with dyskinesia during walking and balance tasks.Methods: Scopus, PubMed, and Web of Science databases were searched. Articles that described gait or balance performance and cortical activity of older Parkinson’s disease (PD), multiple sclerosis, and stroke patients using functional near-infrared spectroscopy were screened by the reviewers. A total of 23 full-text articles were included for review, following an initial yield of 377 studies.Results: Participants were mostly PD patients, the prefrontal cortex was the favorite region of interest, and walking was the most popular test motor task, interventional studies were four. Seven studies used statistical methods to interpret the relationship between motor performance and cortical activation. The motor performance and cortical activation were simultaneously affected under difficult walking and balance task conditions. The concurrent changes of motor performance and cortical activation in reviewed studies contained the same direction change and different direction change.Conclusion: Most of the reviewed studies reported poor motor performance and increased cortical activation of PD, stroke and multiple sclerosis older patients. The external motor performance such as step speed were analyzed only. The design and results were not comprehensive and profound. More than 5 weeks walking training or physiotherapy can contribute to motor function promotion as well as cortices activation of PD and stroke patients. Thus, further study is needed for more statistical analysis on the relationship between motor performance and activation of the motor-related cortex. More different type and program sports training intervention studies are needed to perform.

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“…Two articles adopted walking whilst n-back (Hermand et al, 2019 , 2020 ). Two articles adopted walking whilst a verbal task (Hawkins et al, 2018 ; Lim et al, 2022 ). Only one paper adopted walking whilst picture-planning or stroop (Collett et al, 2021 ).…”

Section: Resultsmentioning

confidence: 99%

“… Sensitivity analysis for comparing PFC activation of ST and DT. When the following studies were excluded, the heterogeneity of the combined results was as follows: I 2 = 9.878% (Al-Yahya et al, 2016 ); I 2 = 6.688% (Chatterjee et al, 2019 ); I 2 = 3.832% (Clark et al, 2021 ); I 2 = 5.709% (Hawkins et al, 2018 ); I 2 = 11.319% (Hermand et al, 2019 ); I 2 = 9.19% (Hermand et al, 2020 ); I 2 = 0% (Collett et al, 2021 ); I 2 = 9.03% (Lim et al, 2022 ); I 2 = 11.411% (Mori et al, 2018 ). …”

Section: Resultsmentioning

confidence: 99%

“…Their outcome measures were also clearly defined and adjusted for the effect of the relationship between exposure and outcome. Five studies examined different levels of the exposure as related to the outcome (Liu et al, 2018 ; Chatterjee et al, 2019 ; Hermand et al, 2019 , 2020 ; Lim et al, 2022 ). Two studies did not implement consistently across all study participants (Hermand et al, 2019 , 2020 ).…”

Section: Resultsmentioning

confidence: 99%

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Brain activation of the PFC during dual-task walking in stroke patients: A systematic review and meta-analysis of functional near-infrared spectroscopy studies

Wang

Dai²,

Xu³

et al. 2023

Front. Neurosci.

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BackgroundDual-task walking is a good paradigm to measure the walking ability of stroke patients in daily life. It allows for a better observation of brain activation under dual-task walking to assess the impact of the different tasks on the patient when combining with functional near-infrared spectroscopy (fNIRS). This review aims to summarize the cortical change of the prefrontal cortex (PFC) detected in single-task and dual-task walking in stroke patients.MethodsSix databases (Medline, Embase, PubMed, Web of Science, CINAHL, and Cochrane Library) were systematically searched for relevant studies, from inception to August 2022. Studies that measured the brain activation of single-task and dual-task walking in stroke patients were included. The main outcome of the study was PFC activity measured using fNIRS. In addition, a subgroup analysis was also performed for study characteristics based on HbO to analyze the different effects of disease duration and the type of dual task.ResultsTen articles were included in the final review, and nine articles were included in the quantitative meta-analysis. The primary analysis showed more significant PFC activation in stroke patients performing dual-task walking than single-task walking (SMD = 0.340, P = 0.02, I2 = 7.853%, 95% CI = 0.054–0.626). The secondary analysis showed a significant difference in PFC activation when performing dual-task walking and single-task walking in chronic patients (SMD = 0.369, P = 0.038, I2 = 13.692%, 95% CI = 0.020–0.717), but not in subacute patients (SMD = 0.203, P = 0.419, I2 = 0%, 95% CI = −0.289–0.696). In addition, performing walking combining serial subtraction (SMD = 0.516, P < 0.001, I2 = 0%, 95% CI = 0.239–0.794), obstacle crossing (SMD = 0.564, P = 0.002, I2 = 0%, 95% CI = 0.205–0.903), or a verbal task (SMD = 0.654, P = 0.009, I2 = 0%, 95% CI = 0.164–1.137) had more PFC activation than single-task walking, while performing the n-back task did not show significant differentiation (SMD = 0.203, P = 0.419, I2 = 0%, 95% CI = −0.289–0.696).ConclusionsDifferent dual-task paradigms produce different levels of dual-task interference in stroke patients with different disease durations, and it is important to choose the matching dual-task type in relation to the walking ability and cognitive ability of the patient, in order to better improve the assessment and training effects.Systematic review registrationhttps://www.crd.york.ac.uk/prospero/, identifier: CRD42022356699.

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Frontal, Sensorimotor, and Posterior Parietal Regions Are Involved in Dual-Task Walking After Stroke

Cited by 16 publications

References 67 publications

Altered neuroimaging patterns of cerebellum and cognition underlying the gait and balance dysfunction in cerebral small vessel disease

Altered neuroimaging patterns of cerebellum and cognition underlying the gait and balance dysfunction in cerebral small vessel disease

Relationship between motor performance and cortical activity of older neurological disorder patients with dyskinesia using fNIRS: A systematic review

Brain activation of the PFC during dual-task walking in stroke patients: A systematic review and meta-analysis of functional near-infrared spectroscopy studies

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