Frontal Theta Cordance Predicts 6-Month Antidepressant Response to Subcallosal Cingulate Deep Brain Stimulation for Treatment-Resistant Depression: A Pilot Study

Broadway, James M.; Holtzheimer, Paul E.; Hilimire, Matthew R.; Parks, Nathan A.; DeVylder, Jordan E.; Mayberg, Helen S.; Corballis, Paul M.

doi:10.1038/npp.2012.23

Cited by 104 publications

(83 citation statements)

References 37 publications

Supporting

Mentioning

Contrasting

Unclassified

Order By: Relevance

“…Several groups have been working to use these local field potentials to develop biomarkers of efficacy such that a closed loop system can be developed. The use of the β band for PD (43), the θ band for depression in thesubcallosal cingulate (44), and the γ band for TS (45) in the centromedian nucleus of the thalamus (CM) may prove to be useful. Several groups are currently using a closed-loop device to record and then stimulate on demand (46).…”

Section: Figurementioning

confidence: 99%

Deep brain stimulation (DBS) at the interface of neurology and psychiatry

Williams¹,

Okun²

2013

J. Clin. Invest.

111

View full text Add to dashboard Cite

Section: Figurementioning

confidence: 99%

Deep brain stimulation (DBS) at the interface of neurology and psychiatry

Williams¹,

Okun²

2013

J. Clin. Invest.

111

View full text Add to dashboard Cite

“…Antidepressant effects with chronic DBS of the subcallosal ACC have been reported across a number of studies [35]; however, there is variability in patient response to this treatment and its invasive nature highlights the particular importance of identifying biomarkers which can be used to refine the use of DBS. A recent study by Broadway et al [36] investigated pretreatment and early treatment EEG markers of response in 12 patients undergoing DBS for depression. Six were classified as responders after 24 weeks of DBS and six were non-responders.…”

Section: Novel Candidate Antidepressant Treatmentsmentioning

confidence: 99%

Neural Predictors of Treatment Response in Depression

Harmer

2014

Curr Behav Neurosci Rep

View full text Add to dashboard Cite

Depression is a leading cause of disability and treatment response is highly variable between patients. The current review focuses on recent findings from studies exploring neural predictors of treatment response to conventional antidepressant drugs, psychological treatment, and novel candidate interventions. Structural markers of response have revealed that decreased volume of key substrates such as the hippocampus and orbitofrontal cortex are predictive of poor response to antidepressant drug treatment, and diffusion tensor imaging offers potentially relevant information for future studies. Pretreatment measures of rostral anterior cingulate activity (from functional magnetic resonance imaging-and electroencephalogram-based approaches) have also been highlighted as a biomarker for antidepressant drug response. The relative utility of measurements taken at baseline versus early change for refining treatment in individual patients is considered. The response to novel treatments such as scopolamine, ketamine, and deep brain stimulation also offer promise for understanding targets of treatment and predictors for tailoring treatment. There is considerable overlap between neural biomarkers for different treatments although positron emission tomography metabolism in the anterior insula may offer a differential predictor of response to pharmacotherapy versus psychotherapy in depression. These insights provide important information about the potential targets and mechanisms underlying the prediction of treatment effects in depression. Future work needs to explore these different predictors between treatment arms in prospectively defined studies to evaluate whether these markers may have utility in the clinic.

show abstract

“…Furthermore, y power has been shown to be a predictor of response to antidepressent medications in resistant depressive disorder (Bares et al, 2008) and combined y and a frontal asymmetry was shown to be a predictor of suicidal ideation during SSRI treatment (Iosifescu et al, 2008). A recent EEG pilot study pointed to frontal y cordance (FTC) at baseline (and higher FTC after 4 weeks) as a response predictor of lower depression severity scores after 24 weeks of stimulation of the SCG (Broadway et al, 2012). Several EEG studies have attempted to correlate asymmetries in resting-state parietal a to depression and anxiety symptoms (Nitschke et al, 1999;Stewart et al, 2011) generally showing an inverted hemispheric relationship between parietal a oscillations and cortical activity (Knyazev, 2007;Thibodeau et al, 2006).…”

Section: Introductionmentioning

confidence: 99%

EEG Power Asymmetry and Functional Connectivity as a Marker of Treatment Effectiveness in DBS Surgery for Depression

Quraan

Protzner

Daskalakis

et al. 2013

Neuropsychopharmacol

View full text Add to dashboard Cite

Recently, deep brain stimulation (DBS) has been evaluated as an experimental therapy for treatment-resistant depression. Although there have been encouraging results in open-label trials, about half of the patients fail to achieve meaningful benefit. Although progress has been made in understanding the neurobiology of MDD, the ability to characterize differences in brain dynamics between those who do and do not benefit from DBS is lacking. In this study, we investigated EEG resting-state data recorded from 12 patients that have undergone DBS surgery. Of those, six patients were classified as responders to DBS, defined as an improvement of 50% or more on the 17-item Hamilton Rating Scale for Depression (HAMD-17). We compared hemispheric frontal theta and parietal alpha power asymmetry and synchronization asymmetry between responders and non-responders. Hemispheric power asymmetry showed statistically significant differences between responders and non-responders with healthy controls showing an asymmetry similar to responders but opposite to non-responders. This asymmetry was characterized by an increase in frontal theta in the right hemisphere relative to the left combined with an increase in parietal alpha in the left hemisphere relative to the right in non-responders compared with responders. Hemispheric mean synchronization asymmetry showed a statistically significant difference between responders and non-responders in the theta band, with healthy controls showing an asymmetry similar to responders but opposite to non-responders. This asymmetry resulted from an increase in frontal synchronization in the right hemisphere relative to the left combined with an increase in parietal synchronization in the left hemisphere relative to the right in non-responders compared with responders. Connectivity diagrams revealed long-range differences in frontal/central-parietal connectivity between the two groups in the theta band. This pattern was observed irrespective of whether EEG data were collected with active DBS or with the DBS stimulation turned off, suggesting stable functional and possibly structural modifications that may be attributed to plasticity.

show abstract

Frontal Theta Cordance Predicts 6-Month Antidepressant Response to Subcallosal Cingulate Deep Brain Stimulation for Treatment-Resistant Depression: A Pilot Study

Cited by 104 publications

References 37 publications

Deep brain stimulation (DBS) at the interface of neurology and psychiatry

Deep brain stimulation (DBS) at the interface of neurology and psychiatry

Neural Predictors of Treatment Response in Depression

EEG Power Asymmetry and Functional Connectivity as a Marker of Treatment Effectiveness in DBS Surgery for Depression

Contact Info

Product

Resources

About