Frontiers in the pathogenesis of kidney disease

Down-regulation of Wt1 activates Wnt/β-catenin signaling through modulating endocytic route of LRP6 in podocyte dysfunction in vitro

“…Chronic kidney disease (CKD), one of the leading factors determin-38 ing human morbidity and mortality, has become a common problem af-39 fecting human health, and it will inevitably progress into end-stage 40 renal disease when renal replacement therapy including hemodialysis 41 and peritoneal dialysis is necessary [1]. The prevalence and incidence 42 of CKD have also posed an enormous challenge for health resources 43 worldwide [2,3].…”