Frontiers of ferroptosis research: An analysis from the top 100 most influential articles in the field

Abstract

In recent years, ferroptosis has become a research hotspot in programmed cell death. Since the concept of ferroptosis was proposed, a growing number of articles have been published on this topic. Nevertheless, to our knowledge, these ferroptosis-related publications that have received a great deal of attention have not been quantitatively evaluated. In this study, we analyzed the top 100 most influential articles over the past decade through a bibliometric method to characterize the research status and trends in this field. Web of Science Core Collection was searched to identify relevant studies. After being manually screened, the top 100 most cited studies with original data were identified and analyzed. Bibliometric software including VOSviewer and R-Bibliometrix were used to perform visualization analysis. The citation frequency for the top 100 selected articles ranged from 135 to 3603 (326.6 citations on average). These articles originated from 25 countries/regions, with more than half originating from the United States and China. The most frequently nominated author was Stockwell BR from the Columbia University, and of the top 100 articles, 19 listed his name. Three core journals were Nature, Cell and Proceedings of the National Academy of Sciences of the United States of America. In addition to term of ferroptosis, these terms or phrases including cell death, cancer cell, GPX4, pathway, inhibitor, mechanism, iron, lipid peroxidation, resistance, erastin, sorafenib, P53, reactive oxygen species, necroptosis, apoptosis, glutathione peroxidase, ACSL4, autophagy, and SLC7A11 appeared more frequently in the top 100 articles. Overall, although much progress has been made, the research on ferroptosis is still at an early stage. The current attention in this field mainly focuses on potential regulatory mechanism and pathways including key ferroptosis-related genes/molecules, oxidant and antioxidant system, ferroptosis-inducing agents or nanomedicine for cancer therapy, as well as the role of ferroptosis in non-neoplastic disorders. Meanwhile, combination therapeutic strategies targeting ferroptosis in radiotherapy or immunotherapy also deserve further attention.

Bibliometric analysis of research on Alzheimer’s disease and non-coding RNAs: Opportunities and challenges

“…Articles with high citations often have important reference value, and sometimes they may be key articles that can lay the foundation for a certain field ( Cheng et al, 2022 ; Li Y. et al, 2022 ). The most cited article in this field is “Amyloid beta: structure, biology and structure-based therapeutic development” published by the research team of Chen et al (2017) .…”

A cuproptosis-related genes signature associated with prognosis and immune cell infiltration in osteosarcoma

“…There are some main functions of metals: to provide structural support, act as cofactors for enzymes, and mediate electron transfer. Moreover, studies have suggested that metal elements were closely linked to the progress of cancers ( 21 , 22 ). Cuproptpsis, an unconventional cell death mechanism associated with fatty acylation of proteins in the TCA cycle, may suggest novel approaches to exploit copper toxicity for tumor therapy.…”

“…Cell death is extremely important in cancer research and underlies the origin and development of tumors ( 57 ). Cuproptosis is a newly found way of cell death that relies on mitochondrial respiration and is different from other forms of cell death such as pyroptosis, ferroptosis and autophagy ( 21 , 22 ). This special mechanism may lead to a new idea for the treatment of OS.…”

Bibliometric analysis of the 100 most-cited papers about the role of gut microbiota in irritable bowel syndrome from 2000 to 2021

“…The relevant data included in this study were downloaded from the Science Citation Index Expanded (SCI-EXPANDED) of Clarivate Analytics Web of Science Core Collection (WoSCC). As the most prestigious global database, WoSCC can provide detailed information needed for bibliometric software and is commonly used in bibliometric analysis (Cheng et al, 2022;Yang et al, 2022;Zhang et al, 2022). The search strategies were as follows: TS = (IBS OR "irritable bowel syndrome*" OR "irritable bowel" OR "irritable colon" OR "irritable bowel disease") AND TS = (gastrointestinal OR gut OR intestinal OR bowel) AND TS= (microbiome OR microbiota OR microorganism OR microbe).…”