Frontispiece: A Cytoprotective and Degradable Metal–Polyphenol Nanoshell for Single‐Cell Encapsulation

Park, Ji Hun; Kim, Kyung-Hwan; Lee, Juno; Choi, Ji Yu; Hong, Daewha; Yang, Sung Ho; Caruso, Frank; Lee, Younghoon; Choi, Insung S.

doi:10.1002/anie.201484661

Cited by 76 publications

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“…After coating with TA, the zeta potential of the surface becomes negative, independent of the surface charge of the bare substrate [17]. FT-IR [25] and Raman spectra [21] Fe III contributing to the cross-linking was estimated to be ~10 mol% for multistep assembly [22] and ~50 mol% for one-step assembly [17,76], as determined by deconvoluted Fe-O (~531.2 eV) and Fe-OH (~533.0 eV) peaks, which can be attributed to the coordination of TA/Fe III and to Fe III aqua hydroxo complexes.…”

Section: Assembly Routes Of Mpns: One-step Vs Multistepmentioning

confidence: 99%

“…For example, the surfaces of bacteria, yeast, animal cells, viruses, and even teeth have been coated with MPNs ( Table 1). The aim of these coatings range from dental hypersensitivity treatment [20,41] to cytoprotection [21] and cellular surface functionalization [39]. The details of each example are described below.…”

Section: Mpn Coatings At Biointerfacesmentioning

confidence: 99%

“…Non-mineralized biointerfaces can also be coated by MPNs, as Park et al [21] demonstrated the coating of S. cerevisiae (yeast) with MPNs for cytoprotection ( Fig. 12) [21].…”

Section: Mpn Coatings At Biointerfacesmentioning

confidence: 99%

“…The number of colony-forming units (CFU) can be calculated by spreading MPN-coated and uncoated yeast cells on agar plates, where values of 3.0 × 10 4 and 1.3 × 10 7 CFU mL -1 were observed for MPN-coated and uncoated yeast, respectively [21]. This is roughly a three-order of magnitude decrease in cellular division activity when compared against uncoated cells.…”

Section: Mpn Coatings At Biointerfacesmentioning

confidence: 99%

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Metal-phenolic networks as a versatile platform to engineer nanomaterials and biointerfaces

2017

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Research Highlights • We review metal-phenolic networks (MPNs), a versatile class of surface coatings and nanostructured functional materials. • Diverse substrates can be coated owing to the universal adherent properties of phenolic moieties. • Coordinated metal ions can be used for cross-linking the films and for engineering additional functionality. • Applications including sensing, imaging, drug delivery, live-cell protection, and catalysis are highlighted.

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Section: Assembly Routes Of Mpns: One-step Vs Multistepmentioning

confidence: 99%

Section: Mpn Coatings At Biointerfacesmentioning

confidence: 99%

“…Non-mineralized biointerfaces can also be coated by MPNs, as Park et al [21] demonstrated the coating of S. cerevisiae (yeast) with MPNs for cytoprotection ( Fig. 12) [21].…”

Section: Mpn Coatings At Biointerfacesmentioning

confidence: 99%

Section: Mpn Coatings At Biointerfacesmentioning

confidence: 99%

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Metal-phenolic networks as a versatile platform to engineer nanomaterials and biointerfaces

2017

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“…Using TA as a ligand, we demonstrated the formation of capsules with engineered pHresponsive degradation, luminescence, and positron emission, by judicious choice of the incorporated metal, 20 as well as pHresponsive drug delivery vectors 21 and cytoprotective coatings. 22 Furthermore, we reported the assembly of Fe IIIpolyphenol capsules from a synthetic poly(ethylene glycol)-based polyphenol, which exhibited reduced protein fouling and nonspecific cellular association compared to TA/Fe III capsules. 23 For the TA systems, initiation of the film assembly is likely to occur by adsorption of TA to the surface and subsequent strong intermolecular (and possibly intramolecular) cross-linking by the metal ions.…”

Section: ■ Introductionmentioning

confidence: 99%

Surface-Confined Amorphous Films from Metal-Coordinated Simple Phenolic Ligands

et al. 2015

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Coordination chemistry of natural polyphenols and transition metals allows rapid self-assembly of conformal coatings on diverse substrates. Herein, we report that this coordination-driven self-assembly process applies to simple phenolic molecules with monotopic or ditopic chelating sites (as opposed to macromolecular, multitopic polyphenols), leading to surface-confined amorphous films upon metal coordination. Films fabricated from gallic acid, pyrogallol, and pyrocatechol, which are the major monomeric building blocks of polyphenols, have been studied in detail. Pyrocatechol, with one vicinal diol group (i.e., bidentate), has been observed to be the limiting case for such assembly. This study expands the toolbox of available phenolic ligands for the formation of surface-confined amorphous films, which may find application in catalysis, energy, optoelectronics, and the biomedical sciences. ■ INTRODUCTIONModular control over the rational design of supramolecular architectures has been achieved in the last two decades by smart engineering of coordination-driven self-assembly processes. 1 Early prediction of the inherent preferences for directionality and binding affinity within the complementary building blocks of coordination complexes has paved the way for fabricating structures with extended networks of metal clusters bridged by compatible organic ligands. 2,3 Porous coordination polymers or metal−organic frameworks (MOFs) with distinct spatial and geometrical arrangements of the interconnecting motifs are examples of such organic−inorganic hybrid materials. 4−7 These crystalline materials with structurally encoded nano-and microporosities have potential application for gas storage, separations, and sensing. 8−13 On the other hand, surface-bound or freestanding amorphous thin films/coatings are another class of network materials of importance in several branches of science, 14−16 where polymeric compounds are commonly used structural components. Research has also focused on exploring novel strategies to incorporate inorganic moieties in polymeric films to obtain functional hybrid materials that exploit the synergistic effects of the organic and inorganic constituents. 17,18 In this context, processes utilizing self-assembly of coordination complexes are a promising strategy toward facile engineering of thin films with defined properties.Recently, we reported a facile assembly approach that exploits metal−polyphenol interactions, specifically between tannic acid (TA) and iron(III) (Fe III ) ions, to form thin films. 19 Our interest in these metal−polyphenol systems arises from the facile and versatile nature of the assembly process, which produces tunable, dynamic materials. Using TA as a ligand, we demonstrated the formation of capsules with engineered pHresponsive degradation, luminescence, and positron emission, by judicious choice of the incorporated metal, 20 as well as pHresponsive drug delivery vectors 21 and cytoprotective coatings. 22 Furthermore, we reported the assembly of Fe IIIpolyphenol capsules fro...

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Polymerization‐Mediated Multifunctionalization of Living Cells for Enhanced Cell‐Based Therapy

et al. 2021

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Recent discoveries in cell biology and microbiology have spotlighted the increasing importance of cell-based therapy, which offers the potential of altering and treating the course of diseases that cannot be addressed sufficiently by existing pharmaceuticals. [1,2] The use of living cells, including transfusion of hematopoietic stem cells, chimeric antigen receptor T-cell therapy, and fecal microbiota transplantation, has been successful in treating a multitude of intractable diseases, such as, congenital defects, cancers, and inflammatory bowel disease. [3,4] Unfortunately, cells are often fragile to unfriendly environmental stressors, such as, temperature fluctuation and centrifugation encountered during preparation, as well as, host immune system and metabolic microenvironment suffered after transplantation, leading to unwanted cell death and a decline in therapeutic efficacy. [5,6] In addition, monomodal therapy always results in inadequately therapeutic response due largely to the complexity of cellular interactions and the multiplicity of cell targets. [7] Therefore, methods capable of simultaneously incorporating with a protection role and endowing with multiple therapeutic modalities are highly desirable to engineer satisfied cells for enhanced cell-based therapy. Surface decoration of living cells, which attaches functional motifs to cell surface, provides a unique tool for generating engineered cells, in a programmed manner, with exogenous characteristics that are neither inherent nor naturally achievable. [8] Particularly, a variety of elegant approaches have been developed to wrap cells chemically with synthetic cytoprotective coatings, forming a cell-in-shell structure. [9-14] For example, a number of mammalian cells have been encapsulated individually with polymers, silica, and calcium phosphate to enhance viability by protecting cells from external aggressors during manipulation, handling, and storage. [12-15] As a representative of fungi, yeast cells have been embedded within a complex of pyrogallol and Fe(III)-tannic acid to improve the tolerance against environmental attacks. [16] Recently, we have encased probiotics with biological membranes to protect bacteria from lethal factors in real-life settings. [17-20] For instance, a beneficial bacterium camouflaged with an erythrocyte membrane exhibits an immunogenic shielding effect, which reduces their clearance by macrophages. [17] However, conventional surface decoration involves tedious complicated fabrication and has limited Surface decoration of living cells by exogenous substances offers a unique tool for understanding and tuning cell behaviors, which plays a critical role in cell-based therapy. Here, a facile yet versatile approach for decorating individual living cells with multimodal coatings is reported. By simply co-depositing with dopamine under a cytocompatible condition, various functional small molecules and polymers can be encoded to form a multifunctional coating on a cell's surface. The accessibility and versatility of this method...

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Frontispiece: A Cytoprotective and Degradable Metal–Polyphenol Nanoshell for Single‐Cell Encapsulation

Abstract: Nanoshells F. Caruso, Y. Lee, I. S. Choi, and co‐workers show in their Communication on that a cytoprotective nanoshell can be formed on individual yeast cells from a coordination complex of tannic acid and FeIII ions.

Cited by 76 publications

References 0 publications

Metal-phenolic networks as a versatile platform to engineer nanomaterials and biointerfaces

Metal-phenolic networks as a versatile platform to engineer nanomaterials and biointerfaces

Surface-Confined Amorphous Films from Metal-Coordinated Simple Phenolic Ligands

Polymerization‐Mediated Multifunctionalization of Living Cells for Enhanced Cell‐Based Therapy

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