Frontispiece: NMR Backbone Assignment of Large Proteins by Using ¹³C_α‐Only Triple‐Resonance Experiments

Abstract

Conformation Analysis NMR spectroscopy is a powerful method to investigate protein structure and dynamics, but backbone resonances in large proteins lead to difficulties. A covariance method utilizes the linear correlation coefficient between two degenerate 13Cα peaks to accelerate assignment; a 42 kDa MDP protein backbone was assigned with 98 % accuracy. For more details, see the Full Paper by K. Ruan, J. Wu, et al. on page 9556 ff.