Frontispiece: Transition Metal Promoted Cascade Heterocycle Synthesis through C−H Functionalization

Abstract

Sequential, domino and tandem reactions could be defined as a sequence of synthetic transformations that occur one after the other, in the same reaction flask. This Review highlights recent advances on the transition‐metal‐mediated C−H activation as a trigger of cascade reactions for the synthesis of heterocycles. To shed some light on this research area at the intersection of two fields, focus was put on the reaction mechanism rather than on the type of metal or the chronological order of the reaction. The aim is to separate and highlight the true domino reactions initiated by C−H activation, compared to other examples of C−H functionalization for heterocycle synthesis. For more details see the Review by D. Maiti, G. Zanoni et al. on page 9749 ff.