Frontoparietal Structural Connectivity in Childhood Predicts Development of Functional Connectivity and Reasoning Ability: A Large-Scale Longitudinal Investigation

Wendelken, Carter; Ferrer, Emilio; Ghetti, Simona; Bailey, Stephen; Cutting, Laurie E.; Bunge, Silvia A.

doi:10.1523/jneurosci.3726-16.2017

Cited by 104 publications

(115 citation statements)

References 37 publications

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“…Here, Complex Cognition is a reflection of nonverbal reasoning, language reasoning, and spatial attention [35]. Our finding is consistent with numerous existing studies in which frontoparietal structural connectivity, including the SLF, has been related to attention [69,70], language [70,71], spatial working memory [72,73], and reasoning ability [74] [75,76], suggesting that its role as a mediator in TD youth may be specific to emergence rather than decline of higherlevel cognitive function.…”

Section: Discussionsupporting

confidence: 89%

Disruptions in White Matter Maturation and Mediation of Cognitive Development in Youth on the Psychosis Spectrum

Hegarty

Jolles

Mennigen³

et al. 2018

Preprint

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Background: Psychosis onset typically occurs in adolescence, and subclinical psychotic experiences peak in adolescence as well. Adolescence is also a time of critical neural and cognitive maturation. Using cross-sectional data from the Philadelphia Neurodevelopmental Cohort, we examine whether regional white matter (WM) development is disrupted in psychosis spectrum (PS) youth whether WM maturation mediates the relationship between age and cognition in typically developing (TD) and PS youth. A third group with intermediate symptom severity (limited PS [LPS]) was included in follow-up analyses to determine whether age-related disruptions in WM scaled with symptom severity.Methods: We examined WM microstructure, as assessed via diffusion tensor imaging, in 707 individuals (aged 10-22 years; 499 TD, 171 PS, 37 LPS) by using Tract-Based Spatial Statistics. Multiple regressions were used to evaluate age x group interactions on regional WM indices. Mediation analyses were conducted using a bootstrapping approach.Results: There were age x group interactions on fractional anisotropy (FA) in the superior longitudinal fasciculus (SLF) and retrolenticular internal capsule (RLIC). SLF FA mediated the relationship between age and Complex Cognition in TD, but not PS. Further, inclusion of LPS youth showed that the relationship between age and SLF FA decreased with increasing symptom severity Conclusions: Our results show aberrant age-related changes in SLF and RLIC FA in PS youth. SLF development supports emergence of specific higher-order cognitive functions in TD youth, but not in PS. Future mechanistic explanations for these relationships could facilitate development of earlier and refined targets for therapeutic interventions.

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Section: Discussionsupporting

confidence: 89%

Disruptions in White Matter Maturation and Mediation of Cognitive Development in Youth on the Psychosis Spectrum

Hegarty

Jolles

Mennigen³

et al. 2018

Preprint

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“…The rostrolateral prefrontal cortex (RLPFC) has been consistently linked with abstract reasoning (30) and the hierarchical control of goal-directed behavior (31). From childhood through early adulthood, the development of structural and functional connectivity between the RLPFC and lateral parietal cortex has been associated with improvements in abstract reasoning ability (30,32) . In this study, we extend these findings by showing that individual differences in RLPFC structure-function coupling partially mediate age-related improvements in executive functioning.…”

Section: Discussionmentioning

confidence: 99%

Development of structure-function coupling in human brain networks during youth

Baum

Cui

Roalf

et al. 2019

Preprint

170

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The protracted development of structural and functional brain connectivity within distributed association networks coincides with improvements in higher-order cognitive processes such as working memory. However, it remains unclear how white matter architecture develops during youth to directly support coordinated neural activity.Here, we characterize the development of structure-function coupling using diffusionweighted imaging and n-back fMRI data in a sample of 727 individuals (ages 8-23 years). We found that spatial variability in structure-function coupling aligned with cortical hierarchies of functional specialization and evolutionary expansion. Furthermore, hierarchy-dependent age effects on structure-function coupling localized to transmodal cortex in both cross-sectional data and a subset of participants with longitudinal data (n=294). Moreover, structure-function coupling in rostrolateral prefrontal cortex was associated with executive performance, and partially mediated age-related improvements in executive function. Together, these findings delineate a critical dimension of adolescent brain development, whereby the coupling between structural and functional connectivity remodels to support functional specialization and cognition.

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“…For instance, Bell and colleagues (e.g., Bell, 2001) have investigated links between children's task-specific performance and engagement of alpha activity during a task relative to a preceding baseline period. Neuroimaging research on the DCCS (from which the MEFS was derived) suggests that successful performance is linked with increased functional activation in the fronto-parietal network (Buss & Spencer, 2017;Ezekiel et al, 2013;Moriguchi & Hirake, 2011;Wendelken et al, 2017) and an attenuated N2 waveform in the ERP, which is most often associated with anterior cingulate activity (Espinet, Anderson, & Zelazo, 2012). In future research we will assess the relations between resting EEG and neural correlates of task performance using a neuroimaging version of the MEFS.…”

Section: G Ener Al Discussionmentioning

confidence: 99%

Age‐related change in brain rhythms from early to middle childhood: Links to executive function

Perone

Palanisamy

Carlson

2018

Developmental Science

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The connection between brain rhythms at rest and cognition remains poorly understood. This is especially true during early childhood in which neuroimaging data are relatively scarce. We developed a new method for collecting eyes closed and eyes open resting state electroencephalography (EEG) suitable for young children. We report results characterizing age-related change in power in multiple brain rhythms over frontal and posterior regions under eyes closed and open conditions of rest in 3-, 4-, 5- and 9-year-old children (N = 162). We observed two key patterns of results. First, with age theta decreased, alpha increased, and alpha peak frequency increased. Second, power was generally higher when eyes were closed than open for theta and alpha but higher when eyes were open than closed for beta and gamma. We also investigated the relation between resting state EEG activity and executive function (EF) using the Minnesota Executive Function Scale, a standardized behavioral measure of EF for ages 2 and up. Correlational and regression analyses showed that individual differences in the theta/beta ratio is associated with EF even after controlling for children's age and verbal abilities. We situate our results in a theoretical discussion of theta/beta and its role in control processes.

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Frontoparietal Structural Connectivity in Childhood Predicts Development of Functional Connectivity and Reasoning Ability: A Large-Scale Longitudinal Investigation

Cited by 104 publications

References 37 publications

Disruptions in White Matter Maturation and Mediation of Cognitive Development in Youth on the Psychosis Spectrum

Disruptions in White Matter Maturation and Mediation of Cognitive Development in Youth on the Psychosis Spectrum

Development of structure-function coupling in human brain networks during youth

Age‐related change in brain rhythms from early to middle childhood: Links to executive function

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