Frontotemporal dementia––a clinically complex diagnosis

Rosness, Tor Atle; Haugen, Per Kristian; Passant, Ulla; Engedal, Knut

doi:10.1002/gps.1992

Cited by 60 publications

(81 citation statements)

References 21 publications

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“…Although the findings regarding time to diagnosis in YOD patients are supported by the previous literature, this period was much longer than that previously found : 3.3 years in the YO-AD group, 4.9 years in the YO-FTD group and 1 year in the LOD group (Wilkinson et al 2004 ;Rosness et al 2008). This discrepancy could be a result of country-related differences or differences in the way the time between symptom onset and diagnosis was estimated.…”

Section: The Age At Onset Effectcontrasting

confidence: 80%

Time to diagnosis in young-onset dementia as compared with late-onset dementia

et al. 2012

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Section: The Age At Onset Effectcontrasting

confidence: 80%

Time to diagnosis in young-onset dementia as compared with late-onset dementia

et al. 2012

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“…The identification of early prodromal states in FTD continues to pose challenges [54]. Studies have found that it can take from 5 to 10 years to make a correct diagnosis [55, 56], and our findings warrant more research to further explain the correlation between anxiety and FTD.…”

Section: Discussionmentioning

confidence: 99%

Anxiety and Depression as Risk Factors in Frontotemporal Dementia and Alzheimer’s Disease: The HUNT Study

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Rosness

Bosnes

et al. 2018

Dement Geriatr Cogn Disord Extra

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Background: The roles of both anxiety and depression as risk factors for frontotemporal dementia (FTD) and Alzheimer’s disease (AD) have not been previously investigated together. Objective: To study anxiety and depression as independent risk factors for FTD and AD. Methods: Eighty-four patients with FTD and 556 patients with AD were compared with 117 cognitively healthy (CH), elderly individuals. Both cases and controls were participants in the second Health Study of Nord-Trøndelag (HUNT2) from 1995 to 1997, in which depression and anxiety were assessed with the Hospital Anxiety and Depression Scale (HADS). Results: Significant associations were found between anxiety and FTD and between depression and AD. A significantly increased risk of developing FTD was observed in patients who had reported anxiety on the HADS (p = 0.017) (odds ratio [OR]: 2.947, 95% confidence interval [CI]: 1.209–7.158) and a significantly increased risk of developing AD was observed in patients who had reported depression on the HADS (p = 0.016) (OR: 4.389, 95% CI: 1.311–14.690). Conclusion: Our study findings suggest that anxiety and depression may play different roles as risk factors for FTD and AD.

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“…It is different from Alzheimer's dementia manifested by impaired executive functioning and progressive semantic or non-fluent aphasia which eventually leads to mutism. [22][23][24][25][26] Recent work has shown that ALS and FTD are both associated with aggregation of ubiquitin-positive inclusion bodies that are positive for the TAR-DNA binding protein TDP-43 (encoded by TARDBP). A number of different mutations in TDP-43 are being discovered.…”

Section: The Clinical Spectrummentioning

confidence: 99%