The development of road network infrastructure is an important component of the economic development of the European Union. Updating of the road network contributes to the integration of the economies of countries into a coherent whole. The road network provides the free movement of citizens, the movement of goods and the effective implementation of various services. The increase in the length of the road network leads to an increase in the financial and material costs necessary to ensure its maintenance and repair. One of the ways to reduce costs is by strengthening the physic-mechanical and operational characteristics of the pavement due to the widespread use of cement concrete. The quality of the pavement of cement concrete depends largely on the rational selection of its composition. This allows a significant increase in the durability of road pavement. The purpose of the research was: the development of recommendations for the rational selection of the composition of the road pavement material of cement concrete, aimed at upgrading longevity, and taking into account its frost resistance grade. According to the goal, the following tasks were developed: the analyses of the climatic zones in which the road network of the European Union is located; the development of a research plan, a selection of the response function and influence factors; the study of physico-mechanical and operational characteristics of the researched material of road pavement; on the basis of the obtained data, the calculation of the complex of experimental-statistical models, which describe the physico-mechanical and operational characteristics of the road pavement material; on the basis of experimental statistical models, a method was proposed for selecting the rational compositions of the cement concrete pavement road material depending on the conditions of its application. The results presented in the article can be used in engineering and scientific practice for the selection of road pavement from cement concrete for highways.