2005
DOI: 10.1016/j.healun.2004.08.013
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Fructose-1,6-Bisphosphate Enhances Hypothermic Preservation of Cardiac Myocytes

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Cited by 7 publications
(14 citation statements)
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“…Although the mechanism is not understood, hypoxanthine is released from cultured human neuronal progenitor cells in response to a hypothermic challenge 31 , and this might explain why hypoxanthine levels were lower in cooled muscles. Increased glucose oxidation helps to protect cultured cardiomyocytes from hypothermia-induced apoptosis 32 , and elevated glucose oxidation in response to cryotherapy may explain the observed decrease in hexose levels observed in the current study. In a wrist flexor eccentric injury study, topical cryotherapy increased the circulating levels of markers of muscle fiber damage, creatine kinase and myoglobin, but decreased the levels of pro-inflammatory cytokines, IL-6, IL-12, and TNF-α 33 .…”
Section: Discussionsupporting
confidence: 53%
“…Although the mechanism is not understood, hypoxanthine is released from cultured human neuronal progenitor cells in response to a hypothermic challenge 31 , and this might explain why hypoxanthine levels were lower in cooled muscles. Increased glucose oxidation helps to protect cultured cardiomyocytes from hypothermia-induced apoptosis 32 , and elevated glucose oxidation in response to cryotherapy may explain the observed decrease in hexose levels observed in the current study. In a wrist flexor eccentric injury study, topical cryotherapy increased the circulating levels of markers of muscle fiber damage, creatine kinase and myoglobin, but decreased the levels of pro-inflammatory cytokines, IL-6, IL-12, and TNF-α 33 .…”
Section: Discussionsupporting
confidence: 53%
“…Thus, millimolar levels of FBP, as used in our previous experiments [18], could reduce extracellular levels of Ca 2+ , which in turn would allow the myocytes to maintain their intracellular Ca 2+ at lower levels and reduce the amount of ATP consumed by Ca 2+ transport.…”
Section: Introductionmentioning
confidence: 83%
“…Our group has characterized effects of FBP in preserving heart function during hypothermic storage [3], [14][15], and has demonstrated uptake of FBP by cardiac myocytes [16][17], even at 3°C [17]. We also showed that in an experimental model for hypothermic heart preservation, isolated cardiac myocytes maintained in ischemic suspension at 3°C, FBP greatly reduced the death rate (as measured by loss of rod-shaped morphology) and helped preserve cellular ATP [18]. In other papers concerning use of FBP with the heart, the compound has been included in the preservation solution in a study of continuous perfusion during cold storage [19], and in clinical trials of coronary artery bypass graft surgery [20]–[21].…”
Section: Introductionmentioning
confidence: 88%
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