Fructose Consumption is Associated with a Higher Risk of Dementia and Alzheimer’s Disease: A Prospective Cohort Study

Yan, Junfeng; Zheng, Kaiyuan; Zhang, X.; Jiang, Yang

doi:10.14283/jpad.2023.7

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Metabolic Changes Associated With Obesity1

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2024

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“… 95 In addition, a prospective study reported individuals with the highest consumption of fructose were at a greater risk of dementia compared to those who reported no fructose intake. 96 Further research into the role fructose and aldose reductase have in metabolism and neurodegenerative diseases is warranted.…”

Section: Metabolic Changes Associated With Obesitymentioning

confidence: 99%

Current Perspectives: Obesity and Neurodegeneration - Links and Risks

Kueck,

Morris,

Stanford

2024

DNND

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Obesity is increasing in prevalence across all age groups. Long-term obesity can lead to the development of metabolic and cardiovascular diseases through its effects on adipose, skeletal muscle, and liver tissue. Pathological mechanisms associated with obesity include immune response and inflammation as well as oxidative stress and consequent endothelial and mitochondrial dysfunction. Recent evidence links obesity to diminished brain health and neurodegenerative diseases such as Alzheimer’s disease (AD) and Parkinson’s disease (PD). Both AD and PD are associated with insulin resistance, an underlying syndrome of obesity. Despite these links, causative mechanism(s) resulting in neurodegenerative disease remain unclear. This review discusses relationships between obesity, AD, and PD, including clinical and preclinical findings. The review then briefly explores nonpharmacological directions for intervention.

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Section: Metabolic Changes Associated With Obesitymentioning

confidence: 99%