Fructose-Containing Sugars and Cardiovascular Disease

Rippe, James M.; Angelopoulos, Theodore J.

doi:10.3945/an.114.008177

Cited by 56 publications

(43 citation statements)

References 137 publications

(139 reference statements)

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“…The SACN report published in 2015 did not find a linkage between sugars consumption and risk factors for heart disease [47]. The evidence in this area, however, is mixed and inconclusive [13]. To our knowledge there are no RCTs assessing a link between added sugars and CVD.…”

Section: Risk Factors For Cardiovascular Diseasementioning

confidence: 99%

“…Added sugars are among the most controversial and hotly debated topics in all of nutrition [5,6,7,8,9,10,11,12,13,14,15,16,17,18,19,20,21,22]. Consumption of added sugars has been associated with increased risk of obesity [23,24,25] as well as increased risk factors for cardiovascular disease (CVD) [26], including dyslipidemia [27,28], elevated blood pressure [20,29,30], diabetes [21,31,32], non-alcoholic fatty liver disease [33,34], and even cognitive decline [35] and cancer [36,37].…”

Section: Introductionmentioning

confidence: 99%

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Relationship between Added Sugars Consumption and Chronic Disease Risk Factors: Current Understanding

2016

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Added sugars are a controversial and hotly debated topic. Consumption of added sugars has been implicated in increased risk of a variety of chronic diseases including obesity, cardiovascular disease, diabetes and non-alcoholic fatty liver disease (NAFLD) as well as cognitive decline and even some cancers. Support for these putative associations has been challenged, however, on a variety of fronts. The purpose of the current review is to summarize high impact evidence including systematic reviews, meta-analyses, and randomized controlled trials (RCTs), in an attempt to provide an overview of current evidence related to added sugars and health considerations. This paper is an extension of a symposium held at the Experimental Biology 2015 conference entitled “Sweeteners and Health: Current Understandings, Controversies, Recent Research Findings and Directions for Future Research”. We conclude based on high quality evidence from randomized controlled trials (RCT), systematic reviews and meta-analyses of cohort studies that singling out added sugars as unique culprits for metabolically based diseases such as obesity, diabetes and cardiovascular disease appears inconsistent with modern, high quality evidence and is very unlikely to yield health benefits. While it is prudent to consume added sugars in moderation, the reduction of these components of the diet without other reductions of caloric sources seems unlikely to achieve any meaningful benefit.

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Section: Risk Factors For Cardiovascular Diseasementioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

Relationship between Added Sugars Consumption and Chronic Disease Risk Factors: Current Understanding

2016

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“…One large clinical study showed a close parallel between the rise in HFCS intake and the obesity and diabetes epidemics in the United States [12]. Excess fructose consumption has been demonstrated to be a risk factor of insulin resistance [13], elevated low-density lipoprotein cholesterol (LDL-c), and triglycerides [14], leading to obesity, type 2 diabetes, and cardiovascular disease [15]. The Nurses’ Health Study cohort study showed that women consuming one or more sugar-sweetened soft drinks per day had an 83% greater risk of developing type 2 diabetes mellitus over the course of eight years compared with those who consumed less than one of these beverages per month [16].…”

Section: An Overview Of Fructosementioning

confidence: 99%

Early Life Fructose Exposure and Its Implications for Long-Term Cardiometabolic Health in Offspring

et al. 2016

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It has become increasingly clear that maternal nutrition can strongly influence the susceptibility of adult offspring to cardiometabolic disease. For decades, it has been thought that excessive intake of fructose, such as sugar-sweetened beverages and foods, has been linked to increased risk of obesity, type 2 diabetes, and cardiovascular disease in various populations. These deleterious effects of excess fructose consumption in adults are well researched, but limited data are available on the long-term effects of high fructose exposure during gestation, lactation, and infancy. This review aims to examine the evidence linking early life fructose exposure during critical periods of development and its implications for long-term cardiometabolic health in offspring.

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“…The value of carbohydrates in a diet usually not only consisted of sugar content but also dietary fiber. Natural sugar in fresh fruits is commonly known as fructose, a type of simple sugar monosaccharide (Rippe & Angelopoulos, 2015) while dietary fibers can also be categorized as complex polysaccharides (Eastwood & Kritchevsky, 2005). Generally, some nutrients such as protein, fat and fiber will be slightly lower in fruit juice compared to its fresh fruit because these nutrients were reduced during the processing of the fruit juice (Mercola 2014).…”

Section: Proximate Composition Of Tp 3 In 1 Tm Fruit Juicementioning

confidence: 99%

Physicochemical Properties, Total Phenolic and Antioxidant Activity of Mixed Tropical Fruit Juice, TP 3 in 1TM

Malek¹,

Haron²,

Mustafa³

et al. 2017

JAS

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This study was carried out on the TP 3 in 1 TM juice formulation, which consisted of pomegranate concentrate with guava and roselle extract. This study aimed to determine its physicochemical properties, proximate content, total phenolic content, antioxidant activity, total sugar, vitamin C and several targeted polyphenol compounds. Total phenol content was determined using Folin-Ciocalteu method while antioxidant activity was determined using DPPH and ABTS methods. The results showed pH and total soluble solid values of the juice were 3.69 and 8.1 °Brix, respectively. The juice has brightness colour of L = 33.25, a = 3.16 and b = -4.63. Every 100 ml juice contained 10.92 g total sugar, 4 mg vitamin C and 0.44% titratable citric acid. Proximate analyses showed TP 3 in 1 TM juice contained 89.38% moisture, 0.15% total ash, 0.16% protein, 0% fat and 10.31% total carbohydrates. The juice was low in calories (42 kcal/100 ml) and contained total phenolic (609 mg GAE/100 ml) and total monomeric anthocyanin (12.94 mg C3G/100 ml). Antioxidant value obtained through DPPH and ABTS test methods were 88.90% and 472.44 µM TE/ml, respectively. Eight selected individual polyphenol compounds ranged from 0.13-633.73 mg/100 ml have been identified. TP 3 in 1 TM juice consisting three different tropical fruits can be considered of having high phenolic content and antioxidant activity. Consumption of mixed tropical juices with various polyphenol compositions will protect human body from several diseases attributed to the reactions of free radicals.

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Fructose-Containing Sugars and Cardiovascular Disease

Cited by 56 publications

References 137 publications

Relationship between Added Sugars Consumption and Chronic Disease Risk Factors: Current Understanding

Relationship between Added Sugars Consumption and Chronic Disease Risk Factors: Current Understanding

Early Life Fructose Exposure and Its Implications for Long-Term Cardiometabolic Health in Offspring

Physicochemical Properties, Total Phenolic and Antioxidant Activity of Mixed Tropical Fruit Juice, TP 3 in 1TM

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