Fructose, glucose and fat interrelationships with metabolic pathway regulation and effects on the gut microbiota

Szabó, József; Maróti, Gergely; Solymosi, Norbert; Andrásofszky, Emese; Tuboly, T.; Bersényi, A.; Bruckner, Géza; Hullár, I.

doi:10.1556/004.2021.00022

Cited by 4 publications

(1 citation statement)

References 97 publications

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“…A Meddiet (olive oil) could counteract the detrimental effects of these metabolites. The disruption of glucose metabolic pathways caused by lard intake will eventually perturb the production and utilization of glucose, the most essential source of energy to maintain cellular activity, which in turn may affect changes in body functions 55) . Folate deficiency causes severe abnormalities in one-carbon metabolism and can result in chronic diseases and developmental disorders, including neural tube defects.…”

Section: Discussionmentioning

confidence: 99%

Comparative Analysis of the Gut Microbiota in Mice under Lard or Vegetable Blend Oil Diet

Qiao

et al. 2022

J. Oleo Sci.

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IntroductionTo sustain life s basic activities, humans must constantly absorb nutrients such as protein, fat, and sugar from the outside world. Among nutrients, fats and oils are not only sources of essential fatty acids, but also carriers of fat-soluble vitamins that protect against high-energy food 1) . Fatty acids are the main component of oil, accounting for about 95％ of the total molecular weight of oil, so the nature of fatty acids determines the nature of oil. Fatty acids mainly include saturated fatty acids (SFA) , monounsaturated fatty acids (MUFA) , and polyunsaturated fatty acids (PUFA) 2) . They come from different dietary sources that determine the type of fat consumed and therefore health outcomes 3) . Lard and vegetable oil are the two most common types of cooking oil and contain different proportions of fatty acids. Studies have found that diets high in fat, protein, and fiber may lead to dysregulation of gut flora, promote local inflammation, enhanced gut wall permeability, increase lipopolysaccharide production, and lead to chronic endotoxemia, which leads to low systemic inflammation and is a precursor to metabolic dysfunction and many modern-day chronic diseases 4−6) . In several studies, diets rich in n-3 PUFA have been linked to reducing or preventing adipose tissue fat accumulation, insulin resistance, inflammation,

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Section: Discussionmentioning

confidence: 99%

Comparative Analysis of the Gut Microbiota in Mice under Lard or Vegetable Blend Oil Diet

Qiao

et al. 2022

J. Oleo Sci.

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Investigation of the relationship between inflammation and microbiota in the intestinal tissue of female and male rats fed with fructose: Modulatory role of metformin

Yalçın Buğdaycı,

Akarca Dizakar,

Demirel

et al. 2024

DARU J Pharm Sci

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Background It has been reported that High-Fructose (HF) consumption, considered one of the etiological factors of Metabolic Syndrome (MetS), causes changes in the gut microbiota and metabolic disorders. There is limited knowledge on the effects of metformin in HF-induced intestinal irregularities in male and female rats with MetS. Objectives In this study, we investigated the sex-dependent effects of metformin treatment on the gut microbiota, intestinal Tight Junction (TJ) proteins, and inflammation parameters in HF-induced MetS. Methods Fructose was given to the male and female rats as a 20% solution in drinking water for 15 weeks. Metformin (200 mg/kg) was administered by gastric tube once a day during the final seven weeks. Biochemical, histopathological, immunohistochemical, and bioinformatics analyses were performed. Differences were considered statistically significant at p < 0.05. Results The metformin treatment in fructose-fed rats promoted glucose, insulin, Homeostasis Model Assessment of Insulin Resistance Index (HOMA-IR), and Triglyceride (TG) values in both sexes. The inflammation score was significantly decreased with metformin treatment in fructose-fed male and female rats (p < 0.05). Moreover, metformin treatment significantly decreased Interleukin-1 Beta (IL-1β) and Tumor Necrosis Factor-Alpha (TNF-α) in ileum tissue from fructose-fed males (p < 0.05). Intestinal immunoreactivity of Occludin and Claudin-1 was increased with metformin treatment in fructose-fed female rats. HF and metformin treatment changed the gut microbial composition. Firmicutes/Bacteroidetes (F/B) ratio increased with HF in females. In the disease group, Bifidobacterium pseudolongum; in the treatment group, Lactobacillus helveticus and Lactobacillus reuteri are the prominent species in both sexes. When the male and female groups were compared, Akkermansia muciniphila was prominent in the male treatment group. Conclusion In conclusion, metformin treatment promoted biochemical parameters in both sexes of fructose-fed rats. Metformin showed a sex-dependent effect on inflammation parameters, permeability factors, and gut microbiota. Metformin has partly modulatory effects on fructose-induced intestinal changes. Graphical Abstract

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Transcriptomic insights into the lipotoxicity of high-fat high-fructose diet in rat and mouse

Zhu,

Luo,

Zhou

et al. 2024

The Journal of Nutritional Biochemistry

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Fructose, glucose and fat interrelationships with metabolic pathway regulation and effects on the gut microbiota

Cited by 4 publications

References 97 publications

Comparative Analysis of the Gut Microbiota in Mice under Lard or Vegetable Blend Oil Diet

Comparative Analysis of the Gut Microbiota in Mice under Lard or Vegetable Blend Oil Diet

Investigation of the relationship between inflammation and microbiota in the intestinal tissue of female and male rats fed with fructose: Modulatory role of metformin

Transcriptomic insights into the lipotoxicity of high-fat high-fructose diet in rat and mouse

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