2016
DOI: 10.1136/bmjopen-2016-013191
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Fructose intake and risk of gout and hyperuricemia: a systematic review and meta-analysis of prospective cohort studies

Abstract: BackgroundThe prevalence of hyperuricemia and gout has increased in recent decades. The role of dietary fructose in the development of these conditions remains unclear.ObjectiveTo conduct a systematic review and meta-analysis of prospective cohort studies investigating the association fructose consumption with incident gout and hyperuricemia.DesignMEDLINE, EMBASE and the Cochrane Library were searched (through September 2015). We included prospective cohort studies that assessed fructose consumption and incide… Show more

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Cited by 87 publications
(61 citation statements)
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“…[34][35][36][37][38][39] It is also difficult to reconcile with our earlier systematic review and meta-analysis showing a positive association between fructose intake and gout, 9 given the emerging links between uric acid and diabetes. 37 One possible explanation for the lack of agreement is residual confounding from reverse causality.…”
Section: Discussionmentioning
confidence: 90%
See 1 more Smart Citation
“…[34][35][36][37][38][39] It is also difficult to reconcile with our earlier systematic review and meta-analysis showing a positive association between fructose intake and gout, 9 given the emerging links between uric acid and diabetes. 37 One possible explanation for the lack of agreement is residual confounding from reverse causality.…”
Section: Discussionmentioning
confidence: 90%
“…8 Owing to concerns regarding the use of cut-off scores, 6 we did not use our prespecified cut-off score for NOS. 9 Differences were reconciled by consensus.…”
Section: Risk Of Biasmentioning
confidence: 99%
“…Increased circulating uric acid levels increase the risk of gout, a condition characterized by painful inflammation due to deposition of uric acid crystals in joints. Indeed, a growing body of evidence implicates sugar intake as a risk factor for gout (75). Moreover, elevated serum uric acid levels and gout are associated with other cardiometabolic risk factors in diverse populations (76)(77)(78).…”
Section: Genetic Lessons About Fructose Metabolismmentioning
confidence: 99%
“…A fruktóz az egyetlen szénhidrát, mely a purinnukleotid-lebontás és a purinszintézis fokozása révén emeli a húgysavszintet. A fruktóz fokozott beviteléért döntően a cukrozott szénsavas üdítőitalok a felelősek [6,25].…”
Section: Társbetegségek Kialakulásaunclassified
“…Diétás és életmódi ajánlás köszvényben [ [25]. Az egyes ételekre és italokra vonatkozó adatok részletes elemzése helyett utalunk néhány hazai [1,2,6,16,31] és nemzetközi összefoglalóra [29,32,33].…”
Section: Táblázatunclassified