Fructose prevents the development of hyperglycaemia in WBN/Kob diabetic fatty rats via maintaining high insulin levels

Abstract

The rapid increase in patients with type 2 diabetes mellitus (T2DM) is a worldwide concern. 1 Excessive carbohydrate consumption, especially fructose as a sweetener, is a risk factor for the development of T2DM. 2 Fructose overconsumption causes obesity, dyslipidaemia, insulin resistance and hyperglycaemia in humans and experimental animals. 3,4 Moreover, fructose increases the plasma glucose level slower than glucose and insulin secretion from β cells is not required for its metabolism.