Fructus Corni suppresses hepatic gluconeogenesis related gene transcription, enhances glucose responsiveness of pancreatic beta-cells, and prevents toxin induced beta-cell death

Chen, Chien-Chih; Hsu, Chin-Hsien; Chen, Chin‐Ying; Liu, Huikang

doi:10.1016/j.jep.2008.02.032

Cited by 65 publications

(37 citation statements)

References 37 publications

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“…Methanol extract and its fractions had potent insulin mimic activity on phosphoenolpyruvate carboxykinase expression. The ability of fractions to protect beta-cell against toxic challenge, and to enhance insulin secretion strengthens the role of Cornus officinalis in diabetes therapy [30] .…”

Section: Cornus Officinalis (Cornaceae)mentioning

confidence: 87%

An overview on antidiabetic medicinal plants having insulin mimetic property

Patel

Prasad

Kumar

et al. 2012

Asian Pacific Journal of Tropical Biomedicine

662

379

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Section: Cornus Officinalis (Cornaceae)mentioning

confidence: 87%

An overview on antidiabetic medicinal plants having insulin mimetic property

Patel

Prasad

Kumar

et al. 2012

Asian Pacific Journal of Tropical Biomedicine

662

379

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“…By conducting in vitro experiments on rat pancreatic β-cells using Cornus officinalis extracts, Chen et al (2008) found that the extracts possessed insulin-mimetic activity and stimulated β-cell function by enhancing insulin secretion and protecting β-cells against toxic damage. Administration of Stevia rebaudiana extracts (Kujur et al, 2010) led to decreased blood glucose levels in diabetic rats.…”

Section: A Plant Extracts With Antidiabetic Actionmentioning

confidence: 99%

Plants and Natural Compounds with Antidiabetic Action

Coman

Rugină

Socaciu

2012

Not Bot Hort Agrobot Cluj

132

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Diabetes has become the most common metabolic disease worldwide. In particular, type 2 diabetes is the most commonly encountered type of diabetes, which is characterised by the inability of the organism to respond to normal levels of circulating insulin, also called insulin resistance. Current antidiabetic therapy is based on synthetic drugs that very often have side effects. For this reason, there is a continuous need to develop new and better pharmaceuticals as alternatives for the management and treatment of the disease. Natural hypoglycaemic compounds may be attractive alternatives to synthetic drugs or reinforcements to currently used treatments. Their huge advantage is that they can be ingested in everyday diet. Recently, more attention is being paid to the study of natural products as potential antidiabetics. This mini review of the current literature is structured into three main sections focused on: (a) plant extracts, (b) plant biomolecules, and (c) other natural molecules that have been used for their antidiabetic effects. Potential molecular mechanisms of action are also discussed.

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“…Gene expression was carried out based on a previous description (Chen et al, 2008). In brief, treated H4IIE cells were directly homogenized in TRI reagent, and RNA was extracted according to the manufacturer's instructions.…”

Section: Reverse-transcription Polymerase Chain Reaction (Rt-pcr)mentioning

confidence: 99%

“…Western blotting was carried out based on a previous description (Chen et al, 2008). In brief, cells were washed with ice-cold phosphate-buffered solution (PBS) twice and scraped into icecold lysis buffer (25 mM Tris/HCl (pH 7.4), 50 mM NaF, 100 mM NaCl, 1 mM sodium vanadate, 5 mM EGTA, 1 mM EDTA, 1% (v/v) Triton X-100, 10 mM sodium pyrophosphate, 1 mM benzamidine, 0.1 mM PMSF, 0.27 M sucrose, 2 M microcystin, and 0.1% (v/v) 2-mercaptoethanol).…”

Section: Western Blotmentioning

confidence: 99%