Fructus lycii: A Natural Dietary Supplement for Amelioration of Retinal Diseases

Neelam, Kumari; Dey, Sonali; Sim, Ralene; Lee, Jason; Eong, Kah‐Guan Au

doi:10.3390/nu13010246

Cited by 47 publications

(25 citation statements)

References 92 publications

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“…Fructus Lycii (FL) has been shown to exhibit multiple biological activities, including antioxidant, 22 anti-inflammatory, 23 antiapoptotic, 24 and neuroprotective activities. 25 The bioactive components of FL are carotenoids, polysaccharides and flavonoids, which exhibit strong antioxidant activities.…”

Section: Discussionmentioning

confidence: 99%

“… 26 The antioxidant properties of FL may be related to endogenous ROS, apoptosis-related genes and deoxyribonucleic acid (DNA) damage. 24 Rehmanniae Radix Praeparata (RRP) plays multiple protective roles in age-related diseases, including diabetes mellitus, 27 neuronal disorders, 28 and inflammation. 29 The bioactive components of RRP are iridoid glycosides, nucleosides, phenethyl alcohol glycosides, and sugars.…”

Section: Discussionmentioning

confidence: 99%

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Exploration of the Effect and Mechanism of Fructus Lycii, Rehmanniae Radix Praeparata, and Paeonia lactiflora in the Treatment of AMD Based on Network Pharmacology and in vitro Experimental Verification

Chen¹,

Zuo²,

Hu³

et al. 2021

DDDT

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Purpose The aim of this study was to observe the mechanism of Fructus Lycii (FL), Rehmanniae Radix Praeparata (RRP) and Paeonia lactiflora (PL) in treating age-related macular degeneration (AMD) based on network pharmacology and biological experiments. Methods Bioactive compounds, potential targets of FL, RRP and PL, and genes related to AMD, were acquired from public databases. Functional and pathway enrichment analyses of the core targets were conducted by Gene Ontology (GO) and Kyoto Encyclopedia of Genes and Genomes (KEGG). Subsequently, the finding was further verified with cell experiments. The MTT assay and flow cytometric analysis were used to assess cell viability and apoptosis. The production of reactive oxygen species (ROS) was analyzed by DCFH-DA staining; the activity of antioxidant enzymes was chemically measured with assay kits. The expression of key proteins was evaluated by Western blot analysis. Results Fifty-nine active compounds, 182 potential targets, and 2536 AMD-related human genes were identified. A total of 103 key targets of the three herbs on AMD were identified by protein–protein interaction (PPI) analysis. The abovementioned targets were correlated with nuclear receptor activity, oxidative stress, and apoptosis pathways according to the GO and KEGG analyses. MTT assay and flow cytometry demonstrated that pretreatment of ARPE-19 cells with the three herbs significantly increased cell viability and decreased apoptosis induced by H 2 O 2 . The three herbs might reduce the intracellular ROS levels and increase the SOD and CAT activities after H 2 O 2 . Furthermore, the three herbs significantly inhibited oxidative stress via increasing the expression of Nrf2, HO-1 and NQO1. Conclusion The combined results of network pharmacology and validation experiments showed that FL, RRP and PL reduce oxidative stress and apoptosis in RPE cells to exert its effect in the treatment of AMD.

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Section: Discussionmentioning

confidence: 99%

Section: Discussionmentioning

confidence: 99%

Exploration of the Effect and Mechanism of Fructus Lycii, Rehmanniae Radix Praeparata, and Paeonia lactiflora in the Treatment of AMD Based on Network Pharmacology and in vitro Experimental Verification

Chen¹,

Zuo²,

Hu³

et al. 2021

DDDT

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“…Dendrobium is widely famous since ancient times for its medical value in treating cataracts. e ingredients extracted from DD are alkaloids, stilbenoids, anthracene, polysaccharides, fluorine, flavone, phenanthrene, and gigantol that have several pharmacological functions, including enhancing immune activities, controlling blood sugar, inhibiting tumor growth, and protecting the liver from oxidative stress [64]. DD is also used for several ophthalmic diseases, such as dry eye and diabetic and ischemic retinopathy.…”

Section: Discussionmentioning

confidence: 99%

Improvement of Presbyopia Using a Mixture of Traditional Chinese Herbal Medicines, Including Cassiae Semen, Wolfberry, and Dendrobium huoshanense

Horng

Ma²,

Shieh

2021

Evidence-Based Complementary and Alternative Medicine

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Background. Presbyopia is a primary cause of a decline in near vision. In this study, we developed a new mixed herbal medicine to retard presbyopic progression and increase the amplitude of accommodation (AA), which is beneficial for near vision. Methods. A total of 400 participants between the ages of 45 and 70 years were recruited. We designed the mixed herbal drug to include Cassiae Semen (200 mg), wolfberry (200 mg), and Dendrobium huoshanense (DD) (40 mg) in one capsule. In experiment 1, the recruited subjects were directed to perform a push-up test to measure their AA; this was then converted to the additional diopters of reading glasses. In experiment 2, 240 subjects took three capsules daily for six months and then stopped medical therapy for a six-month follow-up. In experiment 3, 160 subjects were randomly categorized into four groups: a placebo group, low-dose group (LDG) (1 capsule daily), middle-dose group (MDG) (two capsules daily), and high-dose group (HDG) (three capsules daily). The 160 volunteers took different doses for six months and then stopped treatment, accompanied by another six-month follow-up. In experiments 2 and 3, the change in AA, uncorrected far visual acuity (UFVA), and uncorrected near visual acuity (UNVA) were recorded each month for one year. Results. In experiment 1, AA was found to decrease with age and a great deal of additional power was needed in older individuals. In experiment 2, the mean AA reached a maximum value of 2.1D ( P < 0.05) after six months, while the UNVA improved by about two to three lines of a Jaeger chart in most of the subjects. At nine months, all the means decreased slightly to 2.0 D ( P < 0.05). This meant that the mixed herbal medicine could still maintain AA for another three months because the herbal therapy was stopped at the seventh month. In experiment 3, the maximal AA was 2.8D, 2.9D, and 3.2D ( P < 0.05) in the LDG, MDG, and HDG after six-month treatments, respectively. Experiment 3 showed that AA gain occurred in a dose-dependent manner; the higher the dose, the greater the AA value. Conclusion. Only two studies on the use of herbal drugs for presbyopia have been reported in PubMed. In our study, we found that taking a mixed herbal drug caused an excellent gain in AA. This is the first study to report that the characteristics of the new herbal regimen could retard and even ameliorate presbyopia.

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“…Other components in goji berries may also have in uenced the signi cant increase in MPOD, since the berries contain taurine, vitamin C, zinc, and LBP, which may lower oxidant stress and improve eye health [27][28][29] . Studies on animals and cell lines suggest that bioactive compounds in goji berries, such as LBP, can protect against AMD by reducing oxidative stress and cell apoptosis in retinal pigment epithelium 30 . Taken together, it is reasonable that MPOD may not correlate with skin carotenoids in the goji berry group.…”

Section: Discussionmentioning

confidence: 99%

Goji Berry Intake Increases Macular Pigment Optical Density in Healthy Adults: A Randomized Pilot Trial

Li¹,

Holt²,

Keen³

et al. 2021

Preprint

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Age-related macular degeneration (AMD) is the third leading cause of blindness worldwide. Macular pigment optical density (MPOD), a biomarker for AMD, is a non-invasive measure to assess risk. The macula xanthophyll pigments lutein (L) and zeaxanthin (Z) protect against blue light and provide oxidant defense, which can be indexed by MPOD. This study examined the effects of L- and Z-rich goji berry intake on MPOD and skin carotenoids in healthy individuals. A randomized, unmasked, parallel-arm study was conducted with 27 participants, aged 45–65, who consumed either 28 g of goji berries or a supplement containing 6 mg L and 4 mg Z (LZ), five times weekly for 90 days. After 90 days, MPOD was significantly increased in the goji berry group at 0.25 and 1.75 retinal eccentricities; RE; p = 0.029 and p = 0.044, respectively), while no changes were noted in the LZ group. Skin carotenoids were significantly increased in the goji berry group at day 45 (p = 0.025) and day 90 (p = 0.006), but not in the LZ group. Regular intake of goji berries in a healthy middle-aged population increases MPOD, which may help prevent or delay the development of AMD.

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Fructus lycii: A Natural Dietary Supplement for Amelioration of Retinal Diseases

Cited by 47 publications

References 92 publications

Exploration of the Effect and Mechanism of Fructus Lycii, Rehmanniae Radix Praeparata, and Paeonia lactiflora in the Treatment of AMD Based on Network Pharmacology and in vitro Experimental Verification

Exploration of the Effect and Mechanism of Fructus Lycii, Rehmanniae Radix Praeparata, and Paeonia lactiflora in the Treatment of AMD Based on Network Pharmacology and in vitro Experimental Verification

Improvement of Presbyopia Using a Mixture of Traditional Chinese Herbal Medicines, Including Cassiae Semen, Wolfberry, and Dendrobium huoshanense

Goji Berry Intake Increases Macular Pigment Optical Density in Healthy Adults: A Randomized Pilot Trial

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