Frühdefibrillation am Flughafen Frankfurt

Gaber, Walter; Trappe, Hans‐Joachim

doi:10.1007/s12181-011-0364-9

Cited by 5 publications

(4 citation statements)

References 42 publications

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“…Es ist unbestritten, dass die unverzüg-liche Herzdruckmassage bei gleichzeitiger AED-Anwendung und Alarmierung des Rettungsdienstes zu einer deutlichen Steigerung einer per se schlechten Überlebensrate bei Herz-Kreislauf-Stillstand führen [8,20]. Die Kenntnisse in der AED-Anwendung sind jedoch unter den 2012 befragten LAGO Besuchern nach mehr als 10 Jahren Aufklärungsarbeit nicht höher als bereits 2002 nach einem halben Jahr, auch die Wahrnehmung der im Freizeitbad installierten AED hat sich in der Zwischenzeit nicht verändert.…”

Section: Aed-bezogene Datenunclassified

Einflüsse medizinischer Aufklärungsarbeit auf Erste-Hilfe- und AED-Kenntnisse in der Allgemeinbevölkerung

Christ

Bracht

Prull

et al. 2012

Dtsch med Wochenschr

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Section: Aed-bezogene Datenunclassified

Einflüsse medizinischer Aufklärungsarbeit auf Erste-Hilfe- und AED-Kenntnisse in der Allgemeinbevölkerung

Christ

Bracht

Prull

et al. 2012

Dtsch med Wochenschr

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“…Yb(OTf) En relación a este ácido, se han publicado diversos trabajos sobre su química, desde la actividad de la parte del 1,3-dioxano hasta trabajos más especializados como reacciones multicomponentes, técnicas de pirólisis rápida al vacío (FVP) y más recientemente la síntesis de productos naturales. [65][66][67][68][69][70][71] Asimismo, se sabe que al someterlo a condiciones clásicas de la condensación de Knoevenagel, 72 con aldehídos aromáticos se obtiene satisfactoriamente el correspondiente derivado, Esquema 22. Algunos derivados, que involucran en su proceso de obtención el ácido de Meldrum como las dihidropiridinonas, pueden presentar actividad potencial farmacológica, sobre todo como antagonistas de calcio, debido a su similitud estructural con las DHP's.…”

Section: Figura 7 Dihidropirimidinona Del éSter β-Aminoetilounclassified

Síntesis de heterociclos derivados de boro, mediante el protocolo de la química verde y su evaluación farmacológica

Martínez¹

2013

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In this work, a green approach to produce three sets of boron hybrid heterocyclic esters related to formylphenylboronic acids, is presented and discussed: Hantzsch (1,4-DHP's-B, 6-8 a-c), Biginelli (3,4-DHPM's-B, 9 a-c), and Meldrum (3,4-DHPD's-B, 10-12 a-c). To inside into the three types of esters, above mentioned, the transformations were made among the three regioisomers (ortho, meta, and para) of formylphenylboronic acid 1 a-c, three different β-dicarbonylic compounds 2-4, Meldrum's acid 5, and NH 4 AcO or urea.Related to the Green Chemistry protocol, it is convenient to highlight that a comparative study was performed: evaluating three different modes to activate the reactions (mantle heating as well as infrared and microwave irradiations), resulting microwave irradiation as the best procedure, providing the best yields (17-85 %) with the lower reaction times (15-20 min.); the use of ethanol as solvent (green due to good degradability) was also evaluated; in regard to the use of formylphenylboronic acids, it is worth nothing that they are green compounds, since they are easily degradable by action of enzymes into the liver to boric acid; it is also important to note that the transformations were conducted throughout multicomponent protocols ("one-pot"), being not necessary to isolate the intermediates, that after in situ suffer the corresponding generation of the target products.The products 6-12 a-c were spectroscopically characterized: by 1 H, 13 C, 11 B NMR as well as by EIMS, FAB + MS, HRMS, and infrared spectrophotometric absorption experiments. It is important to mention that the molecules 6-8 a-c and 9 a-c, in their respective FAB + -mode spectra, show adduct-ions related to interactions with the matrix (thioglycerol); these artifacts were invaluable tools to unequivocally characterize the studied molecules.In order to determine how much green are the offered process, a methodology recently described involving the analysis of the twelve Green Chemistry principles was employed; thus in this sense, this work was conveniently evaluated.Finally, a pharmacological screening, for some compounds, about the activity that present over acaricide agents on Rhipicephalus microplus genus tick was also performed; here eleven compounds were evaluated, and larvae eclosion percentage was determined by the Abstract Joel Martínez 4 adults immersion test. It is appropriated to highlight that, the compounds 12d and 12c, have good activity. On the other hand, only the phenylboronic acid showed important activity in larval mortality, when these eleven compounds were evaluated by packet larvae test. In accord to results, these compounds will be considered as potential ixodidae activity. Also, some relaxing activity studies were performed for the 6c, 7c, 8c, and HMOAm (it is 1,4-DHP's-B but with amide residue at 3 and 5 positions

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“…Neben sporadischen Einrichtungen mit AEDs, wie etwa die Arena "Auf Schalke" in Gelsenkirchen oder U-Bahn-Stationen in München, wurden zahlreiche AED-Projekte gestartet. Systematische wissenschaftliche Studien zur Frühdefi-brillation in Deutschland wurden in Kooperation von Ruhr-Universität Bochum, der Deutschen Gesellschaft für Kardiologie -Herz-und Kreislaufforschung und der Deutschen Herzstiftung 2001 gestartet [12,23,25]. Die Ergebnisse dieser 10-jähri-gen Erfahrung sollen hier vorgestellt und kritisch diskutiert werden.…”

Section: Erfahrungen In Deutschlandunclassified

Plötzlicher Herztod und automatisierte externe Defibrillatoren

Trappe

2012

Herz

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Sudden cardiac death (SCD) is one of the major problems in the western world with approximately 70.000-100.000 SCD patients (pts) in Germany and 450.000 SCD victims in the US. SCD is not caused by a single factor but is a multifactorial problem. SCD is caused by ventricular tachyarrhythmias in approximately 90% of pts, whereas SCD is caused by bradyarrhythmias in 5-10%. In 50% of SCD victims, sudden cardiac death is the first manifestation of a heart disease. There is general agreement that early defibrillation with automated external defibrillators (AED) is an effective tool to treat pts with ventricular fibrillation. Nevertheless, further stragies on cardiopulmonary resuscitation and AED therapy are necessary to improve survival of patients with cardiac arrest.

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Frühdefibrillation am Flughafen Frankfurt

Cited by 5 publications

References 42 publications

Einflüsse medizinischer Aufklärungsarbeit auf Erste-Hilfe- und AED-Kenntnisse in der Allgemeinbevölkerung

Einflüsse medizinischer Aufklärungsarbeit auf Erste-Hilfe- und AED-Kenntnisse in der Allgemeinbevölkerung

Síntesis de heterociclos derivados de boro, mediante el protocolo de la química verde y su evaluación farmacológica

Plötzlicher Herztod und automatisierte externe Defibrillatoren

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