Frühe Veränderungen an der Prostata des Hundes nach Kastration

Sinowatz, Fred

doi:10.1159/000145901

Cited by 3 publications

(3 citation statements)

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“…Similarly, in prostatic tissues sampled 41 and 101 days after implantation, there was severe atrophy of the nuclei and the epithelium appeared non‐secretory. These changes in prostatic tissue are similar to those induced in dogs after castration (Sinowatz 1984).…”

Section: Discussionsupporting

confidence: 79%

Morphological Study of the Effects of the GnRH Superagonist Deslorelin on the Canine Testis and Prostate Gland

Junaidi

Williamson²,

Trigg³

et al. 2009

Reprod Domestic Animals

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The present study is part of a programme of research designed to evaluate the efficacy of the GnRH superagonist,deslorelin (D-Trp6-Pro9-des-Gly10-LHRH ethylamide), as a contraceptive for male dogs. Adult dogs were assigned to a completely randomized design comprising six groups of four animals. Each dog in the control group received a blank implant (placebo) and each dog in the other five groups received a 6 mg deslorelin implant. One group of deslorelin treated dogs was sacrificed on each of days 16, 26, 41, 101 and 620, and testicular and prostate tissues were collected for study by light and electron microscopy. On days 16 and 26 after implantation, we observed partial disruption of the seminiferous tubules, with early spermatids shed into the lumen. On days 41 and 101 after implantation, 90–100% of the seminiferous tubules were atrophic and aspermatogenic.On day 101 after implantation, 99% of all sections showed atrophy of the epithelium and shrinkage of epithelial height in the ductus epididymides. On days 41 and 101 after implantation, prostate tissue showed complete atrophy of the glandular epithelium (100% of sections) and an apparent increase in the relative proportion of connective tissue. At the electron microscopic level, in dogs treated with deslorelin for 41 and 101 days, the Sertoli cells were smaller and their nucleoli appeared smaller than in the control dogs. The nucleoli of the Leydig cells were atrophied and prostate glandular epithelium showed reduced epithelial height, a trophy of the nucleolus and an absence of secretory granules.Tissues collected during the recovery phase revealed a complete recovery of spermatogenesis. In conclusion, slow release implants containing deslorelin induce a striking a trophy of the testes and prostate gland by 26 days after implantation, explaining the previously reported loss of ejaculate and arrest of sperm output. At histological level,the entire process appears to be completely reversible, in accordance with data on endocrine variables and semen production.

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Section: Discussionsupporting

confidence: 79%

Morphological Study of the Effects of the GnRH Superagonist Deslorelin on the Canine Testis and Prostate Gland

Junaidi

Williamson²,

Trigg³

et al. 2009

Reprod Domestic Animals

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“…After castration, a striking reduction in prostatic size occurs within a short period of time. In male adult beagles, marked alterations of the glandular epithelium could already be seen 3 days after castration (Sinowatz, 1984). Most acini were severely affected.…”

Section: Effects Of Castration Onmentioning

confidence: 97%

“…After castration of rats, prostatic DNA content decreased 80435%. This is due to autophagic and heterophagic processes (Bruchowsky et al, 1975;Isaacs, 1984;Sinowatz, 1984;Tuohimaa, 1980). Prostatic regression after androgen deprivation is not a passive process but requires the synthesis of specific macromolecules (Bruchowsky et al, 1975).…”

Section: Effects Of Castration Onmentioning

confidence: 99%

Effects of hormones on the prostate in adult and aging men and animals

Sinowatz

Amselgruber

Plendl

et al. 1995

Microscopy Res & Technique

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Literature on the effect of steroid hormones (androgens, estrogens, and other steroids), of peptide hormones (e.g., prolactin), and growth factors (e.g., EGF, FGF, TGF-beta), on the effect of castration and of experimental hormone application on the prostate is reviewed. Androgens have inductive, repressive, and interactive effects. They counterbalance an agonistic effect on proliferation and an antagonistic effect on cell death; they may influence DNA synthesis and induce the synthesis of substances with mitogenic effects on the prostate. Estrogens exert direct and indirect effects on the prostate. They suppress the secretion of gonatropins, thus repressing testicular androgen secretion. They stimulate the fibromuscular stroma and induce squamous metaplasia of the epithelium. Estrogens may also be involved in the onset of benign prostatic hyperplasia. Prolactin is preferentially bound in the diseased human prostate. An abundance of information has been gained on EGF, FGF, TGF-beta, and other growth factors. They may be involved in the development of prostatic hyperplasia. Castration leads to a striking reduction in prostatic size in a short period of time due to autophagic and heterophagic processes. In castrated individuals, the prostate is enriched in androgen-independent cells. Experimental hormone application involves the substitution of androgens as well as anti-androgens, long-term application of different hormones, and application of combinations of drugs. The results of several studies are described. Further directions in the field of prostate research should concentrate on the role of growth factors in prostate development and pathology and on the effect of certain lectins on prostate diseases. We think that the investigation of interactions between steroid hormones and growth factors in normal and pathological neovascularization of the prostate is important.

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The Male Genital System

Ladds

1993

Pathology of Domestic Animals

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Frühe Veränderungen an der Prostata des Hundes nach Kastration

Cited by 3 publications

References 5 publications

Morphological Study of the Effects of the GnRH Superagonist Deslorelin on the Canine Testis and Prostate Gland

Morphological Study of the Effects of the GnRH Superagonist Deslorelin on the Canine Testis and Prostate Gland

Effects of hormones on the prostate in adult and aging men and animals

The Male Genital System

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