Fruit and vegetable consumption before and during pregnancy and developmental delays in offspring aged 2 years in Japan

Yonezawa, Yudai; Ueno, Fumihiko; Obara, Taku; Yamashita, Takahiro; Ishikuro, Mami; Murakami, Keiko; Noda, Aoi; Onuma, Takehide; Sugawara, Junichi; Suzuki, Shigenori; Suganuma, Hiroyuki; Kuriyama, Shinichi

doi:10.1017/s0007114521002154

Cited by 6 publications

(5 citation statements)

References 40 publications

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“…First, differences in nutrient intake due to breakfast frequency may have contributed to this association. Vegetables and fruits are rich in a variety of vitamins, minerals and carotenoids [34], and one study showed that vegetable and fruit intake was associated with a lower risk of developmental delay in children [9]. Fish and PUFAs such as DHA and EPA have been reported to be bene cial for neurodevelopment in children [10,35], and one study showed that folic acid and multivitamin intake before and during pregnancy is bene cial for child development [8].…”

Section: Discussionmentioning

confidence: 99%

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Association Between Frequency of Breakfast Intake Before and During Pregnancy and Developmental Delays in children: The Tohoku Medical Megabank Project Birth and Three-Generation Cohort Study

Aizawa,

Murakami,

Takahashi

et al. 2023

Preprint

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Background Although an association between maternal nutritional intake and developmental delays in children has been demonstrated, the association between the timing of food intake and developmental delays remains unclear. Herein, we examined the association between breakfast intake frequency before and during pregnancy and developmental delay in children.Methods Of the pregnant women who participated in the Tohoku Medical Megabank Project Three-Generation Cohort Study, 7786 answered the required questions and were analyzed. The frequency of breakfast intake from pre- to early pregnancy and from early to mid-pregnancy was classified into four groups: daily, and 5–6, 3–4, and 0–2 times/week. Child developmental delays at age 2 and 3.5 years were assessed using the Ages & Stages Questionnaire, Third Edition. Logistic regression models were constructed to examine the association between breakfast intake frequency in pregnant women and developmental delays in children aged 2 and 3.5 years.Results The proportion of pregnant women who had breakfast daily was 78.2% in pre- to early pregnancy, and 82.3% in early to mid-pregnancy. The proportion of children with developmental delays was 14.7% and 13.4% at age 2 and 3.5 years, respectively. Compared with the risk in children of women who had breakfast daily from pre- to early pregnancy, children of women who had breakfast 0–2 times/week had a higher risk of developmental delays at 2 years of age: odds ratio (OR) 1.33, (95% confidence interval [CI], 1.06–1.68). The risk of developmental delays at age 2 years increased in the children of women who had breakfast 0–2 times/week in early to mid- pregnancy: OR 1.79 (95% CI, 1.36–2.36). Compared with children of women who had breakfast daily from pre- to early and early to mid-pregnancy, children of women who had breakfast 0–2 times/week were not associated with developmental delays at age 3.5 years: OR 1.11 (95% CI, 0.86–1.44 and OR 1.19 (95% CI 0.87–1.62), respectively.Conclusion For women with a low frequency of breakfast intake from pre- to mid-pregnancy there was an association with developmental delays in their children at age 2, but not at 3.5 years.

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Section: Discussionmentioning

confidence: 99%

“…Studies have demonstrated associations between nutrients or foods consumed by pregnant women and developmental delays in the child, including folic acid and multivitamin supplements [8], vegetables, fruit [9],…”

Section: Introductionmentioning

confidence: 99%

Association Between Frequency of Breakfast Intake Before and During Pregnancy and Developmental Delays in children: The Tohoku Medical Megabank Project Birth and Three-Generation Cohort Study

Aizawa,

Murakami,

Takahashi

et al. 2023

Preprint

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“…On the other hand, inadequate fruit and vegetable intake is associated with a greater risk for micronutrient deficiencies, lower GWG [46], lower neonatal birth weight [47][48][49] and length [49], a greater risk of giving birth to low birth weight (LBW) infants [47], an unfavorable infant gut microbiome [50], as well as greater odds of their offspring's developmental delays [51]. Previous Greek data revealed an inadequate fruit and vegetable intake among pregnant women [16], indicating the need for nutrition education.…”

Section: Nutritional Risk Factors During Pregnancymentioning

confidence: 99%

Diet Quality and Nutritional Risk Based on the FIGO Nutrition Checklist among Greek Pregnant Women: A Cross-Sectional Routine Antenatal Care Study

et al. 2023

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The International Federation of Gynecology and Obstetrics (FIGO) nutrition checklist is a tool for everyday antenatal clinical practice, easy to use by most healthcare professionals, aiming to initiate a conversation regarding gestational weight gain (GWG) and nutrition and identify women who might require further assessment. The present cross-sectional study aimed to apply the FIGO nutrition checklist to pregnant women attending routine antenatal care and identify nutritional risk factors. Pregnant women (n = 200) were recruited from the outpatient pregnancy clinics of two hospitals in Thessaloniki and completed the checklist. The FIGO-diet quality score and the FIGO-nutritional risk score (NRS) were calculated. The results revealed that 99% of the women exhibited at least one nutritional risk factor based on the checklist. The median FIGO diet quality score of the sample was 4.0 (3.0–5.0), with 95% of the participants responding negatively to at least one question, indicating the need for improving diet quality. Improved diet quality was noted in cases of hyperemesis gravidarum and among those receiving vitamin D supplements. A large percentage of the participants (36%) exhibited five or more nutritional risk factors, as indicated by a total FIGO-NRS below 5. Women with low middle-upper arm circumference, indicative of protein-energy malnutrition (20.6% of the sample), exhibited more nutritional risk factors compared with the rest. On the other hand, being in the third trimester of pregnancy was associated with lower nutritional risk and, subsequently, better diet quality.

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“…Epidemiological studies confirmed that MD was beneficial to multiple offspring health problems (e.g., preterm delivery, fetal birth weight, early growth, and cardiometabolic risk) ( 8 , 9 ). Beneficial foods in the Mediterranean diet, such as fruits and vegetable consumption during pregnancy, have been shown to support neurodevelopment in offspring ( 10 ). A randomized controlled trial (RCT) study investigated that nuts and olive oil consumption were associated with better nervous system function in humans ( 11 ).…”

Section: Introductionmentioning

confidence: 99%

Mediterranean diet during pregnancy and infant neurodevelopment: A prospective birth cohort study

Dai

Wang²,

Li³

et al. 2023

Front. Nutr.

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BackgroundEmbryonic neural development is associated with intrauterine nutritional status. However, few cohort studies estimated the relationship between maternal dietary patterns during pregnancy and offspring's early neurodevelopment.ObjectiveTo examine the impact of the Mediterranean diet (MD) during pregnancy on infant neurodevelopment, including the potential mediating role of cord blood metabolites.MethodsAmong 1,471 mother–child pairs in a prospective birth cohort study in Hefei, China, we investigated the associations between maternal MD score [calculated based on a validated food frequency questionnaire (FFQ)] and child neurodevelopment at infancy [assessed using Ages and Stages Questionnaires, Third Edition (ASQ-3)]. The cord blood metabolic markers (including C-peptide, high-density lipoprotein-cholesterol, low-density lipoprotein-cholesterol, total cholesterol, and triglycerides) were measured.ResultsThe MD score was negatively associated with communication domain developmental delays in infants [relative risk (RR) with 95% CI: 0.34 (0.16, 0.72)]. Compared with girls, boys born from mothers with lower MD scores during pregnancy were inclined to the failure of the communication domain [RRs with 95% CI for boys: 0.34 (0.14, 0.84); for girls: 0.26 (0.06, 1.18)]. Mediation analysis showed that the association between the maternal MD score and failure of communication domain mediated by C-peptide was 19.4% in boys but not in girls.ConclusionAdhering to the MD during pregnancy was associated with a decreased risk of poor neurodevelopment, possibly mediated by lower levels of cord blood C-peptide.

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Fruit and vegetable consumption before and during pregnancy and developmental delays in offspring aged 2 years in Japan

Cited by 6 publications

References 40 publications

Association Between Frequency of Breakfast Intake Before and During Pregnancy and Developmental Delays in children: The Tohoku Medical Megabank Project Birth and Three-Generation Cohort Study

Association Between Frequency of Breakfast Intake Before and During Pregnancy and Developmental Delays in children: The Tohoku Medical Megabank Project Birth and Three-Generation Cohort Study

Diet Quality and Nutritional Risk Based on the FIGO Nutrition Checklist among Greek Pregnant Women: A Cross-Sectional Routine Antenatal Care Study

Mediterranean diet during pregnancy and infant neurodevelopment: A prospective birth cohort study

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