Fruit and vegetable consumption, pesticide residue intake from consumption of fruits and vegetables, and risk of uterine fibroids

Davis, Colette P; Garzia, Nichole; Cushing‐Haugen, Kara L.; Terry, Kathryn L.; Chiu, Yu‐Han; Sandoval-Insausti, Helena; Chavarro, Jorge E.; Missmer, Stacey A.; Harris, Holly R.

doi:10.1016/j.xfss.2022.12.001

Cited by 4 publications

(4 citation statements)

References 43 publications

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“…However, no significant relationship was observed between the intake of vitamins C, E, folic acid, carotenoids or fiber and uterine leiomyomas [16]. In a prospective cohort study by Davis et al, it was concluded that participants with the highest intake of fruits had a lower risk of uterine fibroids than those consuming the least amount of fruits, also suggesting an inverse correlation between amount of pesticide residues on vegetables and fruits and the prevalence of uterine fibroids [17]. A Chinese study investigating the influence of a vegetarian diet on the prevalence of fibroids found that consumption of broccoli, cabbage, tomato, Chinese cabbage and apple significantly reduced the prevalence of leiomyomas [18].…”

Section: Vegetables and Fruitsmentioning

confidence: 99%

The Role of Nutrition in Pathogenesis of Uterine Fibroids

Krzyżanowski,

Paszkowski,

Woźniak

2023

Nutrients

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Uterine fibroids are benign tumors that arise from the smooth muscle tissue of the uterus and are the most common tumors in women. Due to their high prevalence, costs for the health care system and the substantial impact on women’s quality of life, they are a significant public health concern. Previous literature on the impact of diet on the occurrence, growth and symptoms of fibroids is limited. Recently, many papers have been written on this topic. A scoping review of PubMed and Cochrane databases was performed using the following keywords: uterine fibroids, antioxidants, diet, diet, vegetarian, vegetables, fruits, meat and soy foods, dairy products, tea, vitamin D, vitamin C, ascorbic acid. Preliminary research has shown a beneficial effect of vegetable and fruit consumption on the occurrence of fibroids. A relationship between hypovitaminosis D and an increased risk of fibroids has also been demonstrated. Studies on epigallocatechin gallate showed its apoptosis-promoting and antifibrinolytic effect in fibroid cells. Initial results are promising, but further randomized trials are needed to draw firm conclusions about the effects of diet and nutrients on uterine fibroids.

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Section: Vegetables and Fruitsmentioning

confidence: 99%

The Role of Nutrition in Pathogenesis of Uterine Fibroids

Krzyżanowski,

Paszkowski,

Woźniak

2023

Nutrients

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“…Consuming bell peppers can provide a significant boost to the immune system, helping the body fight off infections and illnesses. Moreover, bell peppers contain antioxidants, which are beneficial compounds that can help prevent the growth of UFs by combating oxidative stress and reducing inflammation [ 10 , 55 ].…”

Section: Optimal Dietary Choices To Consider (Food Modifications)mentioning

confidence: 99%

“…Furthermore, a study conducted by He et al, utilizing a validated self-administered questionnaire, found that higher intakes of vegetables and fruits, as well as engagement in occupational activities, were associated with protective effects against UFs. This suggests that consuming a variety of fruits and vegetables and maintaining an active occupational lifestyle may have a beneficial impact on UF prevention [ 27 , 46 , 55 ].…”

Section: Optimal Dietary Choices To Consider (Food Modifications)mentioning

confidence: 99%

Empowering Strategies for Lifestyle Interventions, Diet Modifications, and Environmental Practices for Uterine Fibroid Prevention; Unveiling the LIFE UP Awareness

Vafaei,

Alkhrait,

Yang

et al. 2024

Nutrients

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Uterine fibroids (UFs) are the most common prevalent benign tumor among women of reproductive age, disproportionately affecting women of color. This paper introduces an innovative management strategy for UFs, emphasizing the curbing of disease prevention and progression. Traditionally, medical intervention is deferred until advanced stages, necessitating invasive surgeries such as hysterectomy or myomectomy, leading to high recurrence rates and increased healthcare costs. The strategy, outlined in this review, emphasizes UF disease management and is named LIFE UP awareness—standing for Lifestyle Interventions, Food Modifications, and Environmental Practices for UF Prevention. These cost-effective, safe, and accessible measures hold the potential to prevent UFs, improve overall reproductive health, reduce the need for invasive procedures, and generate substantial cost savings for both individuals and healthcare systems. This review underscores the importance of a proactive UF management method, paving the way for future research and policy initiatives in this domain.

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“…This includes incorporating vegetables rich in fiber, such as leafy greens, cruciferous vegetables, carrots, sweet potatoes, and bell peppers, which provide essential nutrients and antioxidants that combat inflammation and support hormonal balance [228]. Based upon observational and epidemiological investigations [135], adding fruits like berries, citrus fruits, apples, pineapple, and kiwi to the diet contributes antioxidants, anti-inflammatory compounds, and enzymes that may reduce the risk of UF growth [229]. Omega-3 fatty acids found in fatty fish, flaxseed, chia seeds, walnuts, nuts, and seeds have anti-inflammatory properties that can modulate inflammation associated with UF development [230].…”

Section: Anti-uf Dietmentioning

confidence: 99%

Evidence-Based Approach for Secondary Prevention of Uterine Fibroids (The ESCAPE Approach)

Vafaei,

Ciebiera,

Omran

et al. 2023

IJMS

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Uterine fibroids (UFs) are common tumors in women of reproductive age. It is imperative to comprehend UFs’ associated risk factors to facilitate early detection and prevention. Simple relying on surgical/pharmacological treatment of advanced disease is not only highly expensive, but it also deprives patients of good quality of life (QOL). Unfortunately, even if the disease is discovered early, no medical intervention is traditionally initiated until the disease burden becomes high, and only then is surgical intervention performed. Furthermore, after myomectomy, the recurrence rate of UFs is extremely high with the need for additional surgeries and other interventions. This confused approach is invasive and extremely costly with an overall negative impact on women’s health. Secondary prevention is the management of early disease to slow down its progression or even halt it completely. The current approach of watchful observation for early disease is considered a major missed opportunity in the literature. The aim of this article is to present an approach named the ESCAPE (Evidence-Based Approach for Secondary Prevention) of UF management. It comprises simple, inexpensive, and safe steps that can arrest the development of UFs, promote overall reproductive health, decrease the number of unnecessary surgeries, and save billions of health care systems’ dollars worldwide.

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Fruit and vegetable consumption, pesticide residue intake from consumption of fruits and vegetables, and risk of uterine fibroids

Cited by 4 publications

References 43 publications

The Role of Nutrition in Pathogenesis of Uterine Fibroids

The Role of Nutrition in Pathogenesis of Uterine Fibroids

Empowering Strategies for Lifestyle Interventions, Diet Modifications, and Environmental Practices for Uterine Fibroid Prevention; Unveiling the LIFE UP Awareness

Evidence-Based Approach for Secondary Prevention of Uterine Fibroids (The ESCAPE Approach)

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