Fruit and vegetable juices and breast cancer

Ferreira-Pêgo, Cíntia; Vidović, Bojana; Oliveira, Nuno G.; Fernandes, Ana Sofia; Costa, João Guilherme

doi:10.1016/b978-0-12-819547-5.00021-3

Cited by 3 publications

(4 citation statements)

References 55 publications

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“…Their diversity and unique properties have made them important tools for the research and development of new therapeutic agents [ 16 , 17 ]. Amongst these, phenolic compounds have attracted considerable interest for their wide variety of biological properties, including their antioxidant, antimicrobial, anti-inflammatory, and anticancer activities [ 17 , 18 , 19 , 20 ], but many of them are poorly soluble in water. Rutin, as well as ferulic, caffeic, and p -coumaric acids ( Figure 1 ), are examples of phenolic compounds of pharmaceutical and cosmetic interest [ 14 , 21 , 22 ], but with very low water solubility, which impairs their applicability.…”

Section: Introductionmentioning

confidence: 99%

Upgrading the Topical Delivery of Poorly Soluble Drugs Using Ionic Liquids as a Versatile Tool

Caparica

Júlio

Fernandes

et al. 2021

IJMS

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Numerous studies are continuously being carried out in pursuit of formulations with higher performance. Problems such as poor drug solubility, which hinders drug incorporation into delivery systems and bioavailability, or limitations concerning the stability and performance of the formulations may cause difficulties, since solving all these drawbacks at once is a huge challenge. Ionic liquids (ILs), due to their tunable nature, may hypothetically be synthesized for a particular application. Therefore, predicting the impact of a particular combination of ions within an IL in drug delivery could be a useful strategy. Eight ILs, two choline amino acid ILs, two imidazole halogenated ILs, and four imidazole amino acid ILs, were prepared. Their applicability at non-toxic concentrations, for improving solubility and the incorporation of the poorly soluble, ferulic, caffeic, and p-coumaric acids, as well as rutin, into topical emulsions, was assessed. Next, the impact of the ILs on the performance of the formulations was investigated. Our study showed that choosing the appropriate IL leads to a clear upgrade of a topical emulsion, by optimizing multiple features of its performance, such as improving the delivery of poorly soluble drugs, altering the viscosity, which may lead to better sensorial features, and increasing the stability over time.

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Section: Introductionmentioning

confidence: 99%

Upgrading the Topical Delivery of Poorly Soluble Drugs Using Ionic Liquids as a Versatile Tool

Caparica

Júlio

Fernandes

et al. 2021

IJMS

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“…The content of Anthocyanins in bilberry extracts is higher, which can contribute to stronger effects on cell viability. Indeed, the activity of berry juices could be attributed to the total anthocyanin content or to specific anthocyanin compounds [35]. Polyphenols are a group of substances with health-promoting significance, including high antioxidant potential [36], and a beneficial effect on the regulation of redox homeostasis in cells.…”

Section: Optimization Of Extraction Process Of Vaccinium Myrtillus An...mentioning

confidence: 99%

Anti-Aging Properties of Chitosan-Based Hydrogels Rich in Bilberry Fruit Extract

Studzińska-Sroka,

Paczkowska-Walendowska,

Erdem

et al. 2024

Antioxidants

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Photoaging is a process related to an increased level of reactive oxygen species (ROS). Polyphenols can scavenge free radicals in the body, which can delay skin aging. Therefore, our work aimed to prepare a biologically active extract from dry fruits of Vaccinium myrtillus or Vaccinium corymbosum and use it for the preparation of hydrogels for topical application. Therefore, eight different extracts (using V. myrtillus and V. corymbosum and different extraction mixtures: methanol, methanol–water 1:1, water, acetone–water 1:1) were prepared and their phytochemical (total polyphenolic content, total flavonoid content, total anthocyanin content) and biological properties (antioxidant, anti-hyaluronidase, and anti-tyrosinase activity) were assessed. Cytotoxicity towards HaCaT keratinocytes was also determined. Based on the results, the acetone–water extract from V. myrtillus was selected for further study. Using the Design of Experiments approach, chitosan-based hydrogels with bilberry fruit extract were prepared. The content of extract and chitosan were selected as independent factors. The activity of hydrogels depended on the extract content; however, the enzyme-inhibiting (anti-hyaluronidase and anti-tyrosinase) activity resulted from the presence of both the extract and chitosan. Increased concentration of chitosan in the hydrogel base led to increased viscosity of the hydrogel and, consequently, a slower release of active compounds. To get optimal hydrogel characteristics, 1% extract and 2.5% MMW chitosan were utilized. The research suggests the validity of using bilberry fruit extracts in topical preparations with anti-aging properties.

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“…Tannic acid repressed the Wnt/β-catenin signaling pathway and induced TNF-related apoptosis-inducing ligand (TRAIL)-mediated apoptosis by increasing ROS levels in the mitochondria [54]. Fruits and vegetable juices enriched with biologically active phytochemicals have been suggested to contribute to proliferation inhibition and apoptosis in breast cancer cell lines such as MCF-7 and MDA-MB-231, as well as suppression of breast cancer xenograft tumor growth in rodent models [55]. Indeed, fruit and juice consumption is associated with reduced risk of breast cancer in a dose-dependent manner in a cohort study [56].…”

Section: The Biological Effects Of Fruit-derived Tanninsmentioning

confidence: 99%

“…Indeed, fruit and juice consumption is associated with reduced risk of breast cancer in a dose-dependent manner in a cohort study [56]. It is speculated that the polyphenols of the fruits and vegetables are the main source of the anti-inflammatory and anti-oxidant components which in turn inhibit cancer development [55].…”

Section: The Biological Effects Of Fruit-derived Tanninsmentioning

confidence: 99%

Natural tannins as anti-SARS-CoV-2 compounds

Wang¹,

Chou²,

Hung³

2022

Int. J. Biol. Sci.

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Tannins are polyphenols enriched in wood, bark, roots, leaves, seeds and fruits of a variety of plants. Over the last two decades, there has been an increasing interest in understanding the biological functions of tannins and their applications as antioxidants, anticancer drugs, and food additives. Since the outbreak of the COVID-19 pandemic, much effort has been devoted to finding an expedient cure. Tannins have been put forward as having possible anti-COVID-19 properties; however, owing to the profuse nature of the structurally diverse derivatives of tannins, the tannin species in the family associated with an indication of anti-COVID-19 have been poorly defined, compounded by frequent terminology misnomers. This article reviews the tannin family in fruits and the current knowledge about the activities of the compounds with regard to severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2). It will aid molecular and cellular biologists in developing natural anti-viral chemicals as means of overcoming the current and future pandemics.

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Fruit and vegetable juices and breast cancer

Cited by 3 publications

References 55 publications

Upgrading the Topical Delivery of Poorly Soluble Drugs Using Ionic Liquids as a Versatile Tool

Upgrading the Topical Delivery of Poorly Soluble Drugs Using Ionic Liquids as a Versatile Tool

Anti-Aging Properties of Chitosan-Based Hydrogels Rich in Bilberry Fruit Extract

Natural tannins as anti-SARS-CoV-2 compounds

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