Fruit bioactive compounds: Effect on lactic acid bacteria and on intestinal microbiota

Borgonovi, Taís Fernanda; Virgolin, Lara Borghi; Janzantti, Natália Soares; Casarotti, Sabrina Neves; Penna, Ana Lúcia Barretto

doi:10.1016/j.foodres.2022.111809

Cited by 20 publications

(15 citation statements)

References 232 publications

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“…Previous epidemiological research on apple peels have consistently demonstrated the health advantages of polyphenolic compounds, such as the prevention of metabolic dysfunction and the regulation of gut flora [ 1 , 3 , 4 ]. Koutsos et al [ 5 ] tested the in vitro fermentability of three whole apple varieties using fecal inoculum from human subjects and the authors reported altered microbiota and short chain fatty acids (SCFA) profile, yet the authors reported varietal differences. Nevertheless, the absorption and metabolism of phenolics during digestion, which contribute to the bioavailability of apple phenolics, are necessary for the beneficial biological effects of apple bioactive components [ 5 , 6 ].…”

Section: Introductionmentioning

confidence: 99%

“…Numerous in vitro studies, using human fecal samples for simulated colonic fermentation have reported the conversion of indigestible food components into SCFAs by several genera of colonic bacteria, including Eubacteria , Bacteroides , and Bifidobacteria [ 3 , 10 ]. These bacteria release certain enzymes which are specific to the action of hydrolyzing complex bonds between carbohydrates and polyphenols [ 5 ]. Thus, fermentation of these dietary phenolics and fiber has been reported to improve their relative bioactivity than their precursors [ 11 ].…”

Section: Introductionmentioning

confidence: 99%

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Identification of Phenolics Profile in Freeze-Dried Apple Peel and Their Bioactivities during In Vitro Digestion and Colonic Fermentation

Zahid

Ali

Ranadheera

et al. 2023

IJMS

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Freeze-dried apple peel powder (Fd-APP) was subjected to in vitro digestion and colonic fermentation to evaluate the variations in its phenolic composition, bioactivities (antioxidant activity, α-amylase, and α-glucosidase inhibition), and fecal metabolic outputs. A total of 88 phenolics were tentatively identified, of which 51 phenolic compounds were quantitated in Fd-APP sample extracts before digestion, and 34 were released during subsequent phases of digestion. Among these, phenolic acids showed the highest bio accessibility index (BI) of 68%, followed by flavonoids (63%) and anthocyanins (52%). The inhibitory functions of Fd-APP extract against α-amylase and α-glucosidase pre- and post-digestion were moderate and ranged from 41.88 to 44.08% and 35.23 to 41.13%, respectively. Additionally, the antioxidant activities revealed a significant (p ≤ 0.05) decline during the in vitro digestion. However, the colonic fermentation stage presented different products where the intact parent phenolic compounds present in Fd-APP were utilized by gut microbes and produced various phenolic metabolites such as 3- hydroxyphenyl acetic acid (3-HPAA), ferulic acid (FA), 3-(4-hydroxyphenyl) propionic acid (3,4 HPPA) and 4- hydroxybenzoic acid (4-HBA). Furthermore, colonic fermentation of Fd-APP accelerated the production of short-chain fatty acids (SCFAs), with acetic acid being the most prevalent (97.53 ± 9.09 mM). The decrease in pH of fermentation media to 4.3 significantly (p ≤ 0.05) enhanced counts of Bifidobacterium (10.27 log CFU/mL), which demonstrated the potential prebiotic effects of Fd-APP. These findings indicated that the consumption of apple peel as a constituent of novel functional foods may support and protect the intestinal microbiota and consequently promote human health.

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Section: Introductionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

Identification of Phenolics Profile in Freeze-Dried Apple Peel and Their Bioactivities during In Vitro Digestion and Colonic Fermentation

Zahid

Ali

Ranadheera

et al. 2023

IJMS

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“…Fruits are a source of carbohydrates, fibers, amino acids, acids, minerals, polyphenols, vitamin C, B-complex vitamins, provitamin A, carotenoids, phytosterols, aromatic compounds, and other bioactive compounds that are beneficial to human health [ 74 , 75 , 76 ]. The impact of these bioactive compounds on the intestinal microbiota and the metabolites generated need to be considered to better understand the role of these components and the addition of fruit pulp in microbiota modulation [ 77 , 78 , 79 ].…”

Section: Resultsmentioning

confidence: 99%

Functional Fermented Milk with Fruit Pulp Modulates the In Vitro Intestinal Microbiota

Borgonovi

Salgaço

Oliveira

et al. 2022

Foods

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The effect of putative probiotic fermented milk (FM) with buriti pulp (FMB) or passion fruit pulp (FMPF) or without fruit pulp (FMC) on the microbiota of healthy humans was evaluated. FM formulations were administered into a simulator of the human intestinal microbial ecosystem (SHIME®) to evaluate the viability of lactic acid bacteria (LAB), microbiota composition, presence of short-chain fatty acids (SCFA), and ammonium ions. The probiotic LAB viability in FM was affected by the addition of the fruit pulp. Phocaeicola was dominant in the FMPF and FMB samples; Bifidobacterium was related to FM formulations, while Alistipes was associated with FMPF and FMB, and Lactobacillus and Lacticaseibacillus were predominant in FMC. Trabulsiella was the central element in the FMC, while Mediterraneibacter was the central one in the FMPF and FMB networks. The FM formulations increased the acetic acid, and a remarkably high amount of propionic and butyric acids were detected in the FMB treatment. All FM formulations decreased the ammonium ions compared to the control; FMPF samples stood out for having lower amounts of ammonia. The probiotic FM with fruit pulp boosted the beneficial effects on the intestinal microbiota of healthy humans in addition to increasing SCFA in SHIME® and decreasing ammonium ions, which could be related to the presence of bioactive compounds.

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“…b. Eating at Americas Table Survey: assesses diet quality (Borgonovi et al, 2022). c. Patient Health Survey Depression Scale: valid diagnostic and severity measure for depressive disorders (Kroenke et al, 2009).…”

Section: Survey Datamentioning

confidence: 99%

Food as medicine: a quasi-randomized control trial of two healthy food interventions for chronic disease management among ambulatory patients at an urban academic center

Kibera,

Ofei-Tenkorang,

Mullen

et al. 2023

Prim Health Care Res Dev

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Background: Globally, poor nutrition is a driver of many chronic diseases and is responsible for more deaths than any other risk factor. Accordingly, there is growing interest in the direct provision of healthy foods to patients to tackle diet-linked chronic diseases and mortality. Aim: To assess the effect of two healthy food interventions in conjunction with nutrition counseling and education on select chronic disease markers, food insecurity, diet quality, depression, and on self-efficacy for healthy eating, healthy weight, and chronic disease management. Methods: This parallel-arm quasi-randomized control trial will be conducted between January 2022 and December 2023. Seventy adult patients recruited from a single academic medical center will be randomly assigned to receive either: i) daily ready-made frozen healthy meals or ii) a weekly produce box and recipes for 15 weeks. Participants will, additionally, take part in one individual nutrition therapy session and watch videos on healthy eating, weight loss, type 2 diabetes, and hypertension. Data on weight, height, glycated hemoglobin, blood pressure, and diabetes and blood pressure medications will be collected in-person at the baseline visit and at 16 weeks from baseline and via medical chart review at six months and 12 months from enrollment. The primary outcome of the study is weight loss at 16 weeks from baseline. Pre- and post-intervention survey data will be analyzed for changes in food insecurity, diet quality, depression, as well as self-efficacy for health eating, healthy weight, and chronic disease management. Through retrospective chart review, patients who received standard of care will be matched to intervention group participants as controls based on body mass index, type 2 diabetes, and/or hypertension. Findings: By elucidating the healthy food intervention with better health outcomes, this study aims to offer evidence that can guide providers in their recommendations for healthy eating options to patients.

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Fruit bioactive compounds: Effect on lactic acid bacteria and on intestinal microbiota

Cited by 20 publications

References 232 publications

Identification of Phenolics Profile in Freeze-Dried Apple Peel and Their Bioactivities during In Vitro Digestion and Colonic Fermentation

Identification of Phenolics Profile in Freeze-Dried Apple Peel and Their Bioactivities during In Vitro Digestion and Colonic Fermentation

Functional Fermented Milk with Fruit Pulp Modulates the In Vitro Intestinal Microbiota

Food as medicine: a quasi-randomized control trial of two healthy food interventions for chronic disease management among ambulatory patients at an urban academic center

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