Fruit consumption and the risk of bladder cancer: A pooled analysis by the Bladder Cancer Epidemiology and Nutritional Determinants Study

Abstract

While the association between fruit consumption and bladder cancer risk has been extensively reported, studies have had inadequate statistical power to investigate associations between types of fruit and bladder cancer risk satisfactorily. Fruit consumption in relation to bladder cancer risk was investigated by pooling individual data from 13 cohort studies. Cox regression models with attained age as time scale were used to estimate hazard ratios (HRs) for intakes of total fruit and citrus fruits, soft fruits, stone fruits, tropical fruits, pome fruits and fruit products. Analyses were stratified by sex, smoking status and bladder cancer subtype. During on average 11.2 years of follow‐up, 2836 individuals developed incident bladder cancer. Increasing fruit consumption (by 100 g/day) was inversely associated with the risk of bladder cancer in women (HR = 0.92; 95% CI 0.85‐0.99). Although in women the association with fruit consumption was most evident for higher‐risk nonmuscle invasive bladder cancer (NMIBC; HR = 0.72; 95% CI 0.56‐0.92), the test for heterogeneity by bladder cancer subtype was nonsignificant (P‐heterogeneity = .14). Increasing fruit consumption (by 100 g/day) was not associated with bladder cancer risk in men (HR = 0.99; 95% CI 0.94‐1.03), never smokers (HR = 0.96; 95% CI 0.88‐1.05), former smokers (HR = 0.98; 95% CI 0.92‐1.05) or current smokers (HR = 0.95; 95% CI 0.89‐1.01). The consumption of any type of fruit was not found to be associated with bladder cancer risk (P values > .05). Our study supports no evidence that the consumption of specific types of fruit reduces the risk of bladder cancer. However, increasing total fruit consumption may reduce bladder cancer risk in women.

[Retracted] Tea Drinking and the Risk of Carcinoma of the Urinary Bladder: A Meta‐Analysis

“…Te use of natural food components for human tumor prevention is a hot topic of international research. For example, vegetables and fruits can lower carcinoma of the urinary bladder risk [6,7]. Te medicinal health value of tea has been studied since ancient times.…”

“…[3][4][5]. Vegetables and fruits can lower carcinoma of the urinary bladder risk [6,7]. Some drugs even afect the risk of carcinoma of the urinary bladder.…”

Massnahmen zur Prävention und Früherkennung des Urothelkarzinoms der Harnblase

“…Dabei wurde vor allem bei der Einnahme von Vitaminen (D, A, E), Folsäure, Selenium sowie Früchten und Gemüse ein protektiver Einfluss in systematischen Reviews mitsamt Meta-Analysen beschrieben [24,25]. Die Datenlage hierzu ist abschliessend aber noch zu wenig geklärt [26,27]. Weiter werden der mediterranen Ernährung inklusive der Einnahme von nicht-gesättigten Fettsäuren (Olivenöl) ein schützender Effekt nachgesagt [28,29].…”

Influencia de la bacteriuria significativa en el pronóstico del carcinoma urotelial de vejiga

“…La dieta mediterránea, consumo de vegetales, de grasas no saturadas, así como consumo de frutas se han relacionado como factores protectores frente al carcinoma vesical (19)(20)(21)(22).…”