Fruit Juices of Etcho (Pachycereus pecten-aboriginum) and Giant Cardon (Pachycereus pringlei) are Sources of Health-Promoting Ingredients with Potential Anticancer Properties

Aispuro-Hernández, Emmanuel; de Jesús Vergara-Jiménez, Marcela; Cárdenas-Torres, Feliznando Isidro; Lagarda-Díaz, Irlanda; Martínez-Téllez, Miguel Ángel; Soto-Córdova, Francisco Javier; Corrales-Maldonado, Consuelo Guadalupe; del Carmen Vargas-Arispuro, Irasema; Ontiveros, Noé

doi:10.1007/s11130-023-01099-x

Cited by 2 publications

(1 citation statement)

References 35 publications

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“…Gallic acid is currently studied due to its anticancer properties [41], while chlorogenic acid has remarkable metabolic regulatory features [42] and is a potential botanical insecticide [43]. Myo-inositol (a cyclic polyalcohol) present in plant species, e.g., the Cactaceae family, contributes to overcoming the intracellular deficiencies of inositol and ameliorating the adverse effects caused by its abnormal metabolism, notable in patients at risk of diabetes or insulin resistance and cancer patients [44]. Galactinol or 1-O-alpha-D-galactopyranosyl-L-myo-inositol (plant defense signal), plays a role in the biosynthesis of the raffinose family of oligosaccharides, which are found in plant species and serve as desiccation protectants in seeds and transport sugars [45].…”

Section: Discussionmentioning

confidence: 99%

Sloanea chocoana and S. pittieriana (Elaeocarpaceae): Chemical and Biological Studies of Ethanolic Extracts and Skincare Properties

Quintero-Rincón,

Pino-Benítez,

Galeano

et al. 2023

Plants

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The Colombian Chocó is known for its rich biodiversity and to harbor plant species that are under-explored, including the genus Sloanea. This study aimed to analyze the chemical composition of derivatized ethanolic extracts from S. chocoana and S. pittieriana using BSTFA and TMCS through GC–MS, and to assess cell viability of immortalized human non-tumorigenic keratinocytes (HaCaT) and periodontal ligament fibroblast cells using crude extracts through MTS assay. Antioxidant and photoprotective properties were determined using DPPH assay and spectrophotometry. Antifungal activity of extracts against Candida species was developed following the CLSI standard M27, 4th ed. The sun protective factor (SPF) and UVA/UVB ratio values were calculated using the Mansur equation and the Boots star rating system. The critical wavelength (λc) was determined by calculating the integrated optical density curve’s area. The transmission of erythema and pigmentation was calculated through equations that use constants to calculate the flux of erythema and pigmentation. The GC–MS analysis identified 37 compounds for S. chocoana and 38 for S. pittieriana, including alkaloids, triterpenoids, and polyphenolics, among others. Both extracts exhibited proliferative effects on periodontal ligament fibroblasts, did not affect the viability of HaCaT cells, and showed excellent antioxidant activities (46.1% and 43.7%). Relevant antifungal activity was observed with S. pittieriana extract against Candida albicans (GM–MIC: 4 µg/mL), followed by C. auris and C. glabrata (GM–MIC: 32 µg/mL), while S. chocoana extract was active against C. albicans and C. glabrata (GM–MIC: 16 and 32 µg/mL, respectively). High SPF values (31.0 and 30.0), λc (393.98 and 337.81 nm), UVA/UVB ratio (1.5 and 1.2), and low percentage of transmission of erythema and pigmentation were determined for S. chocoana and S. pittieriana, respectively. Results showed that species of Sloanea constitute a promising alternative as ingredients for developing skincare products, and exhaustive studies are required for their sustainable uses.

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Section: Discussionmentioning

confidence: 99%

Sloanea chocoana and S. pittieriana (Elaeocarpaceae): Chemical and Biological Studies of Ethanolic Extracts and Skincare Properties

Quintero-Rincón,

Pino-Benítez,

Galeano

et al. 2023

Plants

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Phytochemicals from Cactaceae family for cancer prevention and therapy

Orozco-Barocio,

Sánchez-Sánchez,

Rojas-Mayorquín

et al. 2024

Front. Pharmacol.

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Cancer is a global health issue, increasingly prevalent and a leading cause of mortality. Despite extensive research, conventional treatments remain aggressive, often damaging healthy cells, and exhibit limited efficacy. Addressing drug resistance and enhancing treatment effectiveness are critical challenges in advancing cancer therapy. This review examines the potential of natural plant compounds, particularly phytochemicals and their derivatives, in developing novel anticancer agents. These metabolites have a long history in traditional medicine, with 42% of molecules approved for cancer treatment between 1981 and 2019 being either natural products or derivatives. The Cactaceae family, which comprises more than 1,500 species, represents a largely untapped source of potentially useful chemopreventive and anticancer agents. Although more than 3,000 plants and their derivatives have contributed to chemotherapeutic development, cactus species have received limited attention until recently. Emerging evidence highlights the anticancer potential of fruits, stems, and cladodes from various cactus species. This review provides a comprehensive and current overview of experimental studies on Cactaceae in cancer research, aiming to pave the way for the development of innovative, natural cancer therapeutics and contribute to the ongoing battle against this formidable disease.

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Fruit Juices of Etcho (Pachycereus pecten-aboriginum) and Giant Cardon (Pachycereus pringlei) are Sources of Health-Promoting Ingredients with Potential Anticancer Properties

Cited by 2 publications

References 35 publications

Sloanea chocoana and S. pittieriana (Elaeocarpaceae): Chemical and Biological Studies of Ethanolic Extracts and Skincare Properties

Sloanea chocoana and S. pittieriana (Elaeocarpaceae): Chemical and Biological Studies of Ethanolic Extracts and Skincare Properties

Phytochemicals from Cactaceae family for cancer prevention and therapy

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