Fruits and leaves from wild blueberry plants contain diverse polyphenols and decrease neuroinflammatory responses in microglia

Debnath-Canning, Michelle; Unruh, Scott; Vyas, Poorva; Daneshtalab, Noriko; Igamberdiev, Abir U.; Weber, John T.

doi:10.1016/j.jff.2020.103906

Cited by 44 publications

(26 citation statements)

References 45 publications

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“…Research conducted by Debnath-Canning et al also pointed to the remarkable properties of blueberry extracts, demonstrating that they show a protective effect on microglia cells by protecting them against death and the ability to reduce the signs and morphological changes associated with neurological inflammation. These authors also indicated that leaf extracts are characterized by better activity than fruit extracts, which probably results from a greater number of biologically active compounds in the leaves, which was confirmed by HPLC–MS 68 . These studies indicate that the intake of blueberry leaves in the form of dried herbs, extracts, teas or as additives to medicinal products can have a neuroprotective function and play a large role in the chemoprevention of many different diseases, including inflammatory ones.…”

Section: Resultsmentioning

confidence: 77%

Assessment of cytotoxicity and antioxidant properties of berry leaves as by-products with potential application in cosmetic and pharmaceutical products

Ziemlewska

Zagórska‐Dziok

Nizioł–Łukaszewska

2021

Sci Rep

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Vaccinum myrtillus L., Ribes nigrum L., Rubus fruticosus L., Fragaria vesca L. leaves are considered an agro-waste of the berry industry. Although numerous studies indicate fruit is a rich source of bioactive compounds, the authors prove leaves can also be a valuable source of compounds used in the pharmaceutical and cosmetic industries. The study attempts to assess and compare the antioxidant and cytotoxic properties of berry leaves extracts. The total phenolic compounds, flavonoids, anthocyanins and procyanidins content were determined. Antioxidant potential was evaluated using the DPPH radical scavenging method. Cytotoxicity studies were conducted to evaluate the effect of the extracts on the metabolism and proliferation of keratinocytes and fibroblasts in vitro. The effect on the migration capacity of these cells was also assessed. The obtained results show that the examined extracts are a source of valuable bioactive agents. All tested extracts show significant ability to remove free radicals in higher concentrations. Cytotoxicity assessments have shown that leaf extracts of the analyzed plants differ in cytotoxicity, both for keratinocytes and fibroblasts. The results of the assessment of cell migration capacity correlate with cytotoxicity tests, because the concentration of extracts showing cytotoxic activity towards the tested cells also inhibited their migration.

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Section: Resultsmentioning

confidence: 77%

Assessment of cytotoxicity and antioxidant properties of berry leaves as by-products with potential application in cosmetic and pharmaceutical products

Ziemlewska

Zagórska‐Dziok

Nizioł–Łukaszewska

2021

Sci Rep

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“…Flavonoids are potentially the most studied class of polyphenols and have the most subclasses. The majority of flavonoids are found in berries, though berry leaves tend to have higher flavonoid and phenolic content [ 101 ].…”

Section: Mechanisms Of Neuroprotectionmentioning

confidence: 99%

The Pathology of Parkinson’s Disease and Potential Benefit of Dietary Polyphenols

et al. 2020

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Parkinson’s disease (PD) is a progressive neurodegenerative disorder that is characterized by a loss of dopaminergic neurons, leading to bradykinesia, rigidity, tremor at rest, and postural instability, as well as non-motor symptoms such as olfactory impairment, pain, autonomic dysfunction, impaired sleep, fatigue, and behavioral changes. The pathogenesis of PD is believed to involve oxidative stress, disruption to mitochondria, alterations to the protein α-synuclein, and neuroinflammatory processes. There is currently no cure for the disease. Polyphenols are secondary metabolites of plants, which have shown benefit in several experimental models of PD. Intake of polyphenols through diet is also associated with lower PD risk in humans. In this review, we provide an overview of the pathology of PD and the data supporting the potential neuroprotective capacity of increased polyphenols in the diet. Evidence suggests that the intake of dietary polyphenols may inhibit neurodegeneration and the progression of PD. Polyphenols appear to have a positive effect on the gut microbiome, which may decrease inflammation that contributes to the disease. Therefore, a diet rich in polyphenols may decrease the symptoms and increase quality of life in PD patients.

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“…In addition, increased α-synuclein clusters and excessive neurotransmitter glutamate are found in the brain in some specific neurodegenerative diseases [ 36 , 37 ]. Debnath-Canning et al used microglia, the immune cells of the brain, to investigate the effects of BB fruit or leaf extracts on inflammatory responses after the cells were exposed to glutamate (100 µM) or α-synuclein (100 ng/mL) for 24 h [ 31 ]. The treatment (1 µL of sterile filtered 250 mg/mL BB fruit extract or 25 mg/mL BB leaf extract) inhibited cell death and decreased inflammatory conditions, suggesting protection by supplementation against neuroinflammation-associated neurodegenerative disorders [ 31 ].…”

Section: Bioactivity Of Bbs On Brain Health Protection—from In Vitmentioning

confidence: 99%

“…Debnath-Canning et al used microglia, the immune cells of the brain, to investigate the effects of BB fruit or leaf extracts on inflammatory responses after the cells were exposed to glutamate (100 µM) or α-synuclein (100 ng/mL) for 24 h [ 31 ]. The treatment (1 µL of sterile filtered 250 mg/mL BB fruit extract or 25 mg/mL BB leaf extract) inhibited cell death and decreased inflammatory conditions, suggesting protection by supplementation against neuroinflammation-associated neurodegenerative disorders [ 31 ]. The results of this study were also in accordance with those of another study where brain cells from rats were exposed to a high glutamate content (100 μM) for 24 h and BB fruit or leaf extracts showed their excellent ability to protect the cells from glutamate toxicity [ 32 ].…”

Section: Bioactivity Of Bbs On Brain Health Protection—from In Vitmentioning

confidence: 99%

Blueberry Supplementation in Neuronal Health and Protective Technologies for Efficient Delivery of Blueberry Anthocyanins

Tran

2021

Biomolecules

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Blueberries are consumed as healthy fruits that provide a variety of benefits to the nervous system. Scientists have found that blueberries can be used as a daily edible source for supplementation to prevent and minimize complexities of age-related diseases as well as to improve learning and memory in children. Anthocyanins are the most mentioned compounds among the components in blueberries, as they play a major role in providing the health benefits of this fruit. However, while they are highly active in impeding biological impairment in neuronal functions, they have poor bioavailability. This review focuses on neurological investigations of blueberries from in vitro cell studies to in vivo studies, including animal and human studies, with respect to their positive outcomes of neuroprotection and intervention in neurodegenerative conditions. Readers will also find information on the bioavailability of anthocyanins and the considerable factors affecting them so that they can make informed decisions regarding the daily consumption of blueberries. In this context, the ways in which blueberries or blueberry supplementation forms are consumed and which of these forms is best for maximizing the health benefits of blueberries should be considered important decision-making factors in the consumption of blueberries; all of these aspects are covered in this review. Finally, we discuss recent technologies that have been employed to improve the bioavailability of blueberry anthocyanins in the development of effective delivery vehicles supporting brain health.

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Fruits and leaves from wild blueberry plants contain diverse polyphenols and decrease neuroinflammatory responses in microglia

Cited by 44 publications

References 45 publications

Assessment of cytotoxicity and antioxidant properties of berry leaves as by-products with potential application in cosmetic and pharmaceutical products

Assessment of cytotoxicity and antioxidant properties of berry leaves as by-products with potential application in cosmetic and pharmaceutical products

The Pathology of Parkinson’s Disease and Potential Benefit of Dietary Polyphenols

Blueberry Supplementation in Neuronal Health and Protective Technologies for Efficient Delivery of Blueberry Anthocyanins

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