Fruits of Wild-Grown Shrubs for Health Nutrition

Stabnikova, Olena; Stabnikov, Viktor; Paredes-López, Octavio

doi:10.1007/s11130-024-01144-3

Cited by 4 publications

(2 citation statements)

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“…Elderberries are rich in vitamins and antioxidants that are beneficial to human health and hence, have long been used in different food products [4]. The most extensively utilized elderberries are produced from wild-growing elderberry shrubs, which contain more bioactive components than their cultivars [5].…”

Section: Introductionmentioning

confidence: 99%

“…Recently, several review articles on elderberries have been published, which have focused on the antiviral activity of elderberries [18], including effects on respiratory viral infections [19,20], specifically against influenza [21,22] and COVID-19 [23,24]; on the use of elderberries in the food industry [25]; on the chemical components and pharmacological activities of the berries [4,13,14], fruits, and flowers [26][27][28][29], as well as the whole plant of this species [2,3,15,16], and on the constituents and the female reproduction-focused bioactivity of the whole elderberry plant [30]. To complement these previous reviews, the present contribution highlights the development of potential therapeutic agents from elderberries and their small-molecule constituents.…”

Section: Introductionmentioning

confidence: 99%

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Development of Potential Therapeutic Agents from Black Elderberries (the Fruits of Sambucus nigra L.)

Ren,

Meyer,

Anderson

et al. 2024

Molecules

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Elderberry (Sambucus nigra L.) is a widespread deciduous shrub, of which the fruits (elderberries) are used in the food industry to produce different types of dietary supplement products. These berries have been found to show multiple bioactivities, including antidiabetic, anti-infective, antineoplastic, anti-obesity, and antioxidant activities. An elderberry extract product, Sambucol®, has also been used clinically for the treatment of viral respiratory infections. As the major components, phenolic compounds, such as simple phenolic acids, anthocyanins and other flavonoids, and tannins, show promising pharmacological effects that could account for the bioactivities observed for elderberries. Based on these components, salicylic acid and its acetate derivative, aspirin, have long been used for the treatment of different disorders. Dapagliflozin, an FDA-approved antidiabetic drug, has been developed based on the conclusions obtained from a structure–activity relationship study for a simple hydrolyzable tannin, β-pentagalloylglucoside (β-PGG). Thus, the present review focuses on the development of therapeutic agents from elderberries and their small-molecule secondary metabolites. It is hoped that this contribution will support future investigations on elderberries.

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Section: Introductionmentioning

confidence: 99%